OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA) PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA) PDF full book. Access full book title OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA) by OECD. Download full books in PDF and EPUB format.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242341
Category :
Languages : en
Pages : 38
Get Book Here
Book Description
This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264242341
Category :
Languages : en
Pages : 38
Get Book Here
Book Description
This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264916784
Category :
Languages : en
Pages : 42
Get Book Here
Book Description
The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Author: Muhammed Atamanalp
Publisher: Springer Nature
ISBN: 3031566696
Category :
Languages : en
Pages : 189
Get Book Here
Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264076247
Category :
Languages : en
Pages : 33
Get Book Here
Book Description
This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264221417
Category :
Languages : en
Pages : 524
Get Book Here
Book Description
This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264304746
Category :
Languages : en
Pages : 692
Get Book Here
Book Description
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Author: Alexandra Maertens
Publisher: Royal Society of Chemistry
ISBN: 1839164409
Category : Science
Languages : en
Pages : 225
Get Book Here
Book Description
Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.
Author: Cheryl S. Rosenfeld
Publisher: Academic Press
ISBN: 0128151617
Category : Science
Languages : en
Pages : 426
Get Book Here
Book Description
Neuroendocrine Regulation of Animal Vocalization: Mechanisms and Anthropogenic Factors in Animal Communication examines the underpinning neuroendocrine (NE) mechanisms that drive animal communication across taxa. Written by international subject experts, the book focuses on the importance of animal communication in survival and reproduction at an individual and species level, and the impact that increased production and accumulation of endocrine-disrupting chemicals (EDCs) can have on these regulatory processes. This book discusses sound production, perception, processing, and response across a range of animals. This includes insects, fish, bats, birds, nonhuman primates, infant humans, and many others. Some chapters analyze how neuroactive substances, endocrine control, and chemical pollution affect the physiology of the animal's perceptive and sound-producing organs, as well as their auditory and vocal receptors and pathways. Other chapters address the recent approaches governments have taken to protect against the endocrine disruption of animal (vocal) behaviors. The book is a valuable resource for researchers and advanced students seeking first-rate material on neuroendocrinological effects on animal behavior and communication. - Serves as the most comprehensive cross-taxa study of its kind, revolutionary in its focus on the impacts of EDCs on the processes guiding animal communication - Emphasizes the importance of production, perception and processing of acoustic vocalization for survival - Analyzes recent governmental policies and protections against the effects of EDCs on humans and wildlife
Author: Geraldo Medeiros-Neto
Publisher: CRC Press
ISBN: 1000012905
Category : Medical
Languages : en
Pages : 280
Get Book Here
Book Description
First Published in 1994, Inherited Disorders of the Thyroid System presents a thorough and comprehensive study of the biology of varied thyroid disorders illustrated by numerous tables and figures. This monograph begins with the initial step in thyroid hormone production and concludes with the interaction of the thyroid hormones with their target cells. The authors have been involved in research in this field for many years and help to bring together, in a single text, the widely scattered literature relevant to the disorders of the thyroid system.
Author: Committee on Methods for Toxicity Tests with Aquatic Organisms
Publisher:
ISBN:
Category : Aquatic animals
Languages : en
Pages : 82
Get Book Here
Book Description
