OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 120: Solution/Extraction Behaviour of Polymers in Water PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264069887
Category :
Languages : en
Pages : 4
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Book Description
This Test Guideline describes a method to analyse the solution/extraction behaviour of polymers in water, which uses the flask method with modifications. Three samples of 10 g of particles of the test substance are weighed into each of three vessels ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069887
Category :
Languages : en
Pages : 4
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Book Description
This Test Guideline describes a method to analyse the solution/extraction behaviour of polymers in water, which uses the flask method with modifications. Three samples of 10 g of particles of the test substance are weighed into each of three vessels ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069623
Category :
Languages : en
Pages : 4
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Book Description
This Test Guideline describes a method to determine experimentally Pow values in the range log Pow between -2 and 4 (occasionally up to 5). This method can not be used with surface-active materials. The partition coefficient is defined as the ratio ...
Author: OECD
Publisher: OECD Publishing
ISBN: 926406978X
Category :
Languages : en
Pages : 7
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Book Description
This Test Guideline describes methods to determine the surface tension (in N/m) of aqueous solutions. The methods are based on the measurement of the force which it is necessary to exert vertically on a stirrup or ring, in contact with the surface ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069704
Category :
Languages : en
Pages : 16
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Book Description
This Test Guideline describes a laboratory test method to assess abiotic hydrolytic transformations of chemicals in aquatic systems at pH values normally found in the environment (pH 4 – 9). This Guideline is designed as a tiered approach; each tier ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264015841
Category :
Languages : en
Pages : 17
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Book Description
This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of 8.2. The partition coefficient between water and 1-octanol (POW) is defined as the ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069585
Category :
Languages : en
Pages : 7
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Book Description
This Test Guideline describes methods to determine the water solubility of test substances. The water solubility of a substance is the saturation mass concentration of the substance in water at a given temperature. This guideline addresses the ...
Author: Saravana Babu Chidambaram
Publisher: Springer Nature
ISBN: 9811660921
Category : Medical
Languages : en
Pages : 205
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Book Description
This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069828
Category :
Languages : en
Pages : 12
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Book Description
This Test Guideline describes the HPLC method, which permits to determine the partition coefficient (n-octanol/water) (Pow). Reverse phase HPLC is performed on analytical columns packed with a solid phase containing long hydrocarbon chains ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069860
Category :
Languages : en
Pages : 9
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Book Description
This Test guideline describes the Gel Permeation Chromatography (GPC). This method permits to determine the molecular weight distribution and the average molecular weights (Mn, Mw). GPC is a special type of liquid chromatography in which the sample ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069526
Category :
Languages : en
Pages : 8
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Book Description
This Test Guidelines describes several methods and devices to determine the temperature or temperature range of the phase transition from the solid to the liquid state or from the liquid to the solid state. The melting point is defined as the ...
