OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Background Review of the Uterotrophic Bioassay PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264078851
Category :
Languages : en
Pages : 217
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Book Description
This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264078851
Category :
Languages : en
Pages : 217
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Book Description
This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay.
Author: Elsa Nielsen
Publisher: CRC Press
ISBN: 1420006940
Category : Medical
Languages : en
Pages : 450
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Book Description
Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Author: OECD
Publisher: OECD Publishing
ISBN: 9264067418
Category :
Languages : en
Pages : 21
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Book Description
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1490
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264078851
Category :
Languages : en
Pages : 218
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Book Description
This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay. The rodent uterotrophic bioassay is being validated as part of the OECD Test Guidelines Programme. The rodent uterotrophic bioassay is based on the principle that the uterus is under the control of oestrogens to stimulate and maintain growth. If endogenous sources of this hormone are not available, the animal will require an exogenous source to initiate and/or restore uterine growth.
Author:
Publisher:
ISBN:
Category : Endocrine glands
Languages : en
Pages : 746
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070966
Category :
Languages : en
Pages : 10
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Book Description
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Author: Harry Salem
Publisher: CRC Press
ISBN: 0203008790
Category : Medical
Languages : en
Pages : 618
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Book Description
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Author: Vinod P. Shah
Publisher: Springer
ISBN: 1493912895
Category : Medical
Languages : en
Pages : 393
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Book Description
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309109922
Category : Nature
Languages : en
Pages : 217
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Book Description
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
