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Author: Tarik Issad
Publisher: Frontiers Media SA
ISBN: 2889634256
Category :
Languages : en
Pages : 238
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Author: Tarik Issad
Publisher: Frontiers Media SA
ISBN: 2889634256
Category :
Languages : en
Pages : 238
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Author: John D. Wade
Publisher: Frontiers Media SA
ISBN: 2832500692
Category : Science
Languages : en
Pages : 222
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Author: Tony Lefebvre
Publisher: Frontiers Media SA
ISBN: 2889195910
Category : Diseases of the endocrine glands. Clinical endocrinology
Languages : en
Pages : 115
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Book Description
Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart.
Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category : Medical
Languages : en
Pages : 694
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Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Leonardo Freire-de-Lima
Publisher: Frontiers Media SA
ISBN: 2832518486
Category : Medical
Languages : en
Pages : 226
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Author: Thomas Wisniewski
Publisher: Frontiers Media SA
ISBN: 2889711374
Category : Science
Languages : en
Pages : 143
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Author: Jose M. Eirin-Lopez
Publisher: Frontiers Media SA
ISBN: 2889669777
Category : Science
Languages : en
Pages : 218
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Author: Mojgan Rastegar
Publisher: Frontiers Media SA
ISBN: 2889715140
Category : Science
Languages : en
Pages : 182
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Author: Ganglong Yang
Publisher: Frontiers Media SA
ISBN: 2889746704
Category : Science
Languages : en
Pages : 231
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Author: Ye Li
Publisher: Frontiers Media SA
ISBN: 2832532845
Category : Medical
Languages : en
Pages : 198
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