Novel Approaches in Treating Major Depressive Disorder (depression) PDF Download
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Author: Milena Ćukić Radenković
Publisher:
ISBN: 9781536143829
Category : Depression, Mental
Languages : en
Pages : 0
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Book Description
Depression is a serious problem. Serious problems often need a complex solution. In her description of novel approaches to treating depression, Dr Radenković is summarising her results from the beginning of her scientific endeavour. As an engineer of electronics with a strong background in theoretical physics, biophysicist and neuroscientist, she aims at filling in the gap between disciplines needed to bring the innovation in the treatment of depression. Starting from the history of electrical and magnetic stimulation important for this field, she is combining the knowledge from biophysics and electromagnetic to explain how both modalities of stimulation can affect our neural tissue. Reviewing the most essential concepts in physiological complexity, she illustrates all the relevant research in different attempts to understand how we can detect the very subtle changes characteristic for a disorder. Those can be recognised from several electrical signals recorded from the body (electrophysiological signals). Fractal and nonlinear measures are in use for several decades, but are still not widely utilized in clinical practice due to deeply rooted obsolete mathematical models originated from the 19th century. Connecting the powerful models from machine learning (data mining) with measures of complexity and irregularity, Dr Radenković demonstrates how their synergy can bring innovative solutions in psychiatry. She tackles crucial questions like "Should scientific research in psychiatry go online?" One of the central questions she is trying to answer is why two modalities of electromagnetic stimulation-rTMS and tDCS- are effective in treatments of depression. A combination of fractal and nonlinear analysis and a well-performed machine learning can become a useful addition to present practice: decision support solution. We can consider it a test which is accessible, easy to use and cost-effective in comparison to many other methodologies tested in contemporary scientific literature. The question is, how long it takes that something scientifically proven translates to clinical practice. Remember how long it took for all doctors to start washing their hands. We can only hope this translation would be faster. Many people need that badly.
Author: Milena Ćukić Radenković
Publisher:
ISBN: 9781536143829
Category : Depression, Mental
Languages : en
Pages : 0
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Book Description
Depression is a serious problem. Serious problems often need a complex solution. In her description of novel approaches to treating depression, Dr Radenković is summarising her results from the beginning of her scientific endeavour. As an engineer of electronics with a strong background in theoretical physics, biophysicist and neuroscientist, she aims at filling in the gap between disciplines needed to bring the innovation in the treatment of depression. Starting from the history of electrical and magnetic stimulation important for this field, she is combining the knowledge from biophysics and electromagnetic to explain how both modalities of stimulation can affect our neural tissue. Reviewing the most essential concepts in physiological complexity, she illustrates all the relevant research in different attempts to understand how we can detect the very subtle changes characteristic for a disorder. Those can be recognised from several electrical signals recorded from the body (electrophysiological signals). Fractal and nonlinear measures are in use for several decades, but are still not widely utilized in clinical practice due to deeply rooted obsolete mathematical models originated from the 19th century. Connecting the powerful models from machine learning (data mining) with measures of complexity and irregularity, Dr Radenković demonstrates how their synergy can bring innovative solutions in psychiatry. She tackles crucial questions like "Should scientific research in psychiatry go online?" One of the central questions she is trying to answer is why two modalities of electromagnetic stimulation-rTMS and tDCS- are effective in treatments of depression. A combination of fractal and nonlinear analysis and a well-performed machine learning can become a useful addition to present practice: decision support solution. We can consider it a test which is accessible, easy to use and cost-effective in comparison to many other methodologies tested in contemporary scientific literature. The question is, how long it takes that something scientifically proven translates to clinical practice. Remember how long it took for all doctors to start washing their hands. We can only hope this translation would be faster. Many people need that badly.
Author: Roger S McIntyre
Publisher: Elsevier Health Sciences
ISBN: 0323581323
Category : Medical
Languages : en
Pages : 202
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Book Description
Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.
Author: Madhukar H. Trivedi
Publisher: Oxford University Press
ISBN: 019092957X
Category : Medical
Languages : en
Pages : 400
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Book Description
Major depressive disorder (MDD) is a serious, debilitating, life-shortening illness that affects many persons of all ages and backgrounds. The lifetime risk for MDD is 7-12% for men and 20-25% for women (Kessler et al., 2003). MDD is a disabling disorder that costs the U.S. over $200 billion per year in direct and indirect costs (Greenberg et al., 2015), and is the leading cause of disability worldwide (WHO, 2018). Depression also has detrimental effects on all aspects of social functioning (e.g., self-care, social role, and family life, including household, marital, kinship, and parental roles). While there have been several treatments that are efficacious, many individuals suffering from depression experience life-long challenges due to the chronic and episodic nature of the disease. Identifying strategies to find the right treatments for the right patients is critical. Ongoing research has explored the importance of examining physiologic biomarkers, as well as clinical characteristics to gain a better understanding of subtypes of depression, which will lead to improved treatments and better outcomes. This book provides an introduction to the etiology and pathophysiology of depression, common comorbidities and differential diagnoses, pharmacotherapy strategies, psychotherapeutic and neuromodulation interventions, novel and non-traditional treatment strategies, and considerations in special populations.
Author: Paula J. Clayton
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 362
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Book Description
Author: Thomas Frodl
Publisher: Academic Press
ISBN: 0128026286
Category : Psychology
Languages : en
Pages : 420
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Book Description
Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables
Author: Jonathan Edward Alpert
Publisher: CRC Press
ISBN: 0824756606
Category : Psychology
Languages : en
Pages : 400
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Book Description
An in-depth and authoritative framework for clear understanding of the origins, development, and management of chronic depression, this timely reference examines biological, psychosocial, and combined approaches to the treatment of chronic depression-providing strategies to achieve remission, reduce relapse and recurrence, and manage treatment-emergent side-effects in long-term patient care.
Author: Hector J. Carun
Publisher: Frontiers Media SA
ISBN: 2889630439
Category :
Languages : en
Pages : 111
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Book Description
Author: Joao Luciano de Quevedo
Publisher: Academic Press
ISBN: 0128133341
Category : Medical
Languages : en
Pages : 471
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Book Description
Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression
Author: Aaron T. Beck, M.D.
Publisher: University of Pennsylvania Press
ISBN: 9780812219647
Category : Psychology
Languages : en
Pages : 436
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Book Description
The second edition of Depression: Causes and Treatment provides a contemporary review of the diagnosis, causes, and treatments of depression. Both biological and psychological treatment approaches are described.
Author: American Psychiatric Association
Publisher: American Psychiatric Publishing
ISBN: 9780890425664
Category : Mental illness
Languages : en
Pages : 0
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Book Description
This handy DSM-5(R) Classification provides a ready reference to the DSM-5 classification of disorders, as well as the DSM-5 listings of ICD-9-CM and ICD-10-CM codes for all DSM-5 diagnoses. To be used in tandem with DSM-5(R) or the Desk Reference to the Diagnostic Criteria From DSM-5(R), the DSM-5(R) Classification makes accessing the proper diagnostic codes quick and convenient. With the advent of ICD-10-CM implementation in the United States on October 1, 2015, this resource provides quick access to the following: - The DSM-5(R) classification of disorders, presented in the same sequence as in DSM-5(R), with both ICD-9-CM and ICD-10-CM codes. All subtypes and specifiers for each DSM-5(R) disorder are included.- An alphabetical listing of all DSM-5 diagnoses with their associated ICD-9-CM and ICD-10-CM codes.- Separate numerical listings according to the ICD-9-CM codes and the ICD-10-CM codes for each DSM-5(R) diagnosis.- For all listings, any codable subtypes and specifiers are included with their corresponding ICD-9-CM or ICD-10-CM codes, if applicable. The easy-to-use format will prove indispensable to a diverse audience--for example, clinicians in a variety of fields, including psychiatry, primary care medicine, and psychology; coders working in medical centers and clinics; insurance companies processing benefit claims; individuals conducting utilization or quality assurance reviews of specific cases; and community mental health organizations at the state or county level.
