Notch Regulation of the Immune System PDF Download
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Author: Freddy Radtke
Publisher: Springer Science & Business Media
ISBN: 3642242944
Category : Medical
Languages : en
Pages : 192
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Book Description
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Author: Freddy Radtke
Publisher: Springer Science & Business Media
ISBN: 3642242944
Category : Medical
Languages : en
Pages : 192
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Book Description
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Author: Freddy Radtke
Publisher: Springer
ISBN: 9783642242953
Category : Medical
Languages : en
Pages : 184
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Book Description
Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Author: Koji Yasutomo
Publisher: Springer
ISBN: 9811049718
Category : Medical
Languages : en
Pages : 106
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Book Description
This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.
Author: Isabelle Godin
Publisher: Springer Science & Business Media
ISBN: 0387335358
Category : Medical
Languages : en
Pages : 188
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Book Description
This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.
Author:
Publisher: CSHL Press
ISBN: 9780879695705
Category : Cell receptors
Languages : en
Pages : 656
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Book Description
Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.
Author: Alborz Borjian
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"An effective immune response against pathogens or cancer requires proper guidance of the immune system. Being the first responders in innate immunity, Dendritic Cells (DCs) provide essential and differentiation cues to T cells, guiding them down specific effector lineages. Cell-cell communication through Notch signaling is initiated by trans-binding of receptor and ligand on neighboring cells to guide various cell fate decisions. However, recently it has been shown that cis-interaction of Notch receptor and Delta ligand in mammalian cells can result in inhibition of Notch signaling. DCs are known to express both Notch ligands and receptors. We have previously shown that DCs differentially express Notch ligands in response to stimuli associated with specific TH lineages. These findings suggest that relative abundance of Notch ligands to receptors may lead the cell to adopt a phenotype associated with signaling through either Notch ligand or receptor. Thereby, we hypothesize that the Notch signaling directly regulates DC function and therefore indirectly modulates T-cell polarization. To observe Notch signaling associated with different states of DC activation, we measured expression of components of Notch signal transduction in response to the Toll-like receptor (TLR) ligand lipopolysaccharide (LPS) and Leishmania parasites. Activation of DCs with TH1-directing LPS maintains the low Notch1 levels, but increases Notch2 expression. DCs infected with Leishmania remain immature, even if exposed to LPS subsequently, show higher Notch1 levels. Analysis of Notch1-deficient DCs, illustrated that Notch1 expression negatively regulates DC activation. Similarly, DCs stimulated with TH1-inducing agents maintain low Notch1 levels but have increased Delta4 expression. On the other hand, Notch2 expression positively regulates DC activation. Induced Notch2 expression leads to increased expression of co-stimulatory molecule CD86 and proinflammatory cytokine Interleukin 12 (IL-12). The increased Notch2 expression in DCs stimulated with LPS is, however, accompanied by a reduction in Jagged2 expression. Accordingly, Jagged2 is shown to negatively regulate IL-12 secretion. Such pattern of expression among Notch ligands and receptors (i.e. mutually exclusive expression of Notch1/Delta4 or Notch2/Jagged2) supports the evidence for cis-inhibition, a mechanism by which Notch receptors and ligands expressed on the same cell reciprocally inhibit one another. Such cis-interaction results in removal of the receptors and ligands from the cell surface and their subsequent proteolysis. All in all, our results propose that relative levels of Notch receptor and ligands can directly alter DC phenotype." --
Author: Tilman Borggrefe
Publisher: Springer
ISBN: 3319895125
Category : Science
Languages : en
Pages : 417
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Book Description
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Author: Vivian Siegel
Publisher:
ISBN:
Category : Genetic regulation
Languages : en
Pages : 148
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Book Description
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Michael John Malecki
Publisher:
ISBN: 9780549042938
Category :
Languages : en
Pages : 156
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Book Description
Notch signaling is a developmentally conserved pathway involved in cell fate determination. One development program in which Notch signaling plays a prominent role is in the development of the immune system, where Notch1, one of four mammalian Notch receptors, guides the choice of T-cell fate. However, mutations leading to aberrant increases in Notch1 signaling are associated with T-cell Acute Lymphoblastic Leukemia (T-ALL), indicating the importance of regulation in modulating the timing and strength of Notch1 signals. Notch receptors are synthesized as single-chain type-I transmembrane proteins. During transit through the trans -golgi, Notch receptors are typically cleaved by a furin-like protease, resulting in two subunits that are non-covalently associated through a subunit heterodimerization (HD) domain. The majority of leukemia-associated mutations in human Notch1, which are found in about 40% of T-ALLs, lie in this HD domain.
