New-opathies: An Emerging Molecular Reclassification Of Human Disease PDF Download
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Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 981445849X
Category : Medical
Languages : en
Pages : 310
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Book Description
This book presents new insights into the etiology and pathogenesis of systemic diseases recently discovered to be due to specific defects in molecular assemblies, organelles, or other subcellular structures. This new information, of great importance to medical students, physicians, and basic scientists, has not been incorporated into major medical textbooks.The volume will be an important resource for medical or graduate students, investigators and physicians, as it covers major new insights into diverse diseases and concepts missing from pathology textbooks. Each of the eight chapters in the book is written by a leader in the field.
Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 981445849X
Category : Medical
Languages : en
Pages : 310
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Book Description
This book presents new insights into the etiology and pathogenesis of systemic diseases recently discovered to be due to specific defects in molecular assemblies, organelles, or other subcellular structures. This new information, of great importance to medical students, physicians, and basic scientists, has not been incorporated into major medical textbooks.The volume will be an important resource for medical or graduate students, investigators and physicians, as it covers major new insights into diverse diseases and concepts missing from pathology textbooks. Each of the eight chapters in the book is written by a leader in the field.
Author:
Publisher:
ISBN:
Category : Diseases
Languages : en
Pages : 0
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Book Description
Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 981120098X
Category : Science
Languages : en
Pages : 155
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Book Description
Fixing Your Damaged and Incorrect Genes is a book about a well-established biological process called DNA REPAIR. The book describes the multiple and varied biochemical strategies by which damaged or incorrect nucleotides are removed from DNA or are corrected. The book includes multiple figures of notable past and present scientists in the field. The book is uniquely focused on an audience of non-biologists and is written in simple language with minimal use of technical terms. It contains an extensive glossary that provides explanations of key words that readers are encouraged to refer to as they read. Fixing Your Damaged and Incorrect Genes is unique, there being no previously published books for non-biologists on the topic of DNA repair.
Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 9813272635
Category : Science
Languages : en
Pages : 125
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Book Description
Genes were unknowingly discovered in the 19th century by Gregor Mendel, a Czechoslovakian monk. It was later established that genes are made of DNA, a biological compound found in tiny thread-like structures called chromosomes that are located in the nuclei of all cells in our bodies. DNA consists of chains of entities called bases of which there are four in nature. DNA consists of long chains of bases (sometimes referred to as DNA sequences) that are joined in any order, but the precise order and length of which constitute different genes.Many (but not all) genes carry a code called the genetic code, a code that instructs the synthesis (manufacture) of the many hundreds of proteins that we require to survive and execute the many functions of life. The genetic code was deciphered in relatively recent years and is considered one of the most significant discoveries in the history of biology.Genes that encode instructions for the synthesis of proteins and those that regulate the manufacture of proteins comprise a mere two percent of our DNA. Despite our extensive knowledge of biology and the sub-discipline of molecular biology (the study of biology at the molecular level), the function (if any) of the rest of the DNA in our cells is unknown.Research about genes and DNA has in recent years spawned an endeavor referred to as the Human Genome Project, an international collaboration that has successfully determined, stored, and rendered publicly available the sequences of almost all the genetic content of the chromosomes of the human organism, otherwise known as the human genome.DNA sequences that are unique to every person on earth have been discovered (DNA fingherprints) and are now used for identifying criminals. The book relates a specific example of identifying a criminal who murdered two women.This is the first and only book that we are aware of that educates non-biologists about genes. It is written in a style and uses a vocabulary that can be comprehended by the average reader who knows very little if anything about genes.
Author: Serge Morand
Publisher: Springer Science & Business Media
ISBN: 9400721145
Category : Medical
Languages : en
Pages : 335
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Book Description
Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.
Author: Stephen Gillespie
Publisher: John Wiley & Sons
ISBN: 0470035323
Category : Medical
Languages : en
Pages : 620
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Book Description
Since the publication of the last edition of Principles and Practice of Clinical Bacteriology, our understanding of bacterial genetics and pathogenicity has been transformed due to the availability of whole genome sequences and new technologies such as proteomics and transcriptomics. The present, completely revised second edition of this greatly valued work has been developed to integrate this new knowledge in a clinically relevant manner. Principles and Practice of Clinical Bacteriology, Second Edition, provides the reader with invaluable information on the parasitology, pathogenesis, epidemiology and treatment strategies for each pathogen while offering a succinct outline of the best current methods for diagnosis of human bacterial diseases. With contributions from an international team of experts in the field, this book is an invaluable reference work for all clinical microbiologists, infectious disease physicians, public health physicians and trainees within these disciplines.
Author: D. W. Molander
Publisher: Springer Science & Business Media
ISBN: 1461251982
Category : Medical
Languages : en
Pages : 357
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Book Description
This volume presents a practical approach for clinicians who work with patients afflicted with diseases of the lymphoid system and bone marrow. Associated biochemical, hematological, and chromosomal abnormalities, as well as infectious complications, are covered because of their importance in managing patients with lymphatic diseases. In addition, cell kinetics and the classification of lym phocytic lymphomas are included because familiarity with these subjects leads to a better understanding of the physiology of the disease. Radiological techniques that aid the clinician in the diagnosis and management of diseases of the lymphoid tissue are discussed. The explosive interest in patients with generalized acquired (auto) immune deficiency syndrome (AIDS) prompted the inclusion of a chapter exclusively devoted to this topic. Finally, the chapter dealing with psychological aspects of patients with cancer allows the reader to become familiar with useful techniques. Distilled from a vast array of data and representing the most up-to-date material available, this volume is intended to be of interest to internists, oncolo gists, hematologists, radiotherapists, nurses, and anyone in an associated pa ramedical field who may be involved in the care of patients with diseases of the lymphatic system. Acknowledgements: I am indebted to the following for their help in making this volume possible: Mr. Rudy De Angelo and the Hudson County Chapter of the Pack Medical Foundation, Mrs. Louis Berkoff, Mrs. Frances Goldman, The Pack Medical Foundation, Mr. and Mrs. Julius Schure and Mr. Richard Schure. DAVID W. MOLANDER, M.D.
Author: Jerry McCauley
Publisher: Springer Nature
ISBN: 3030830829
Category : Medical
Languages : en
Pages : 448
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Book Description
Chronic kidney disease (CKD) is a major global public health problem, affecting nearly one in seven adults in the United States alone. It is a disease that integrates chronic illness at several levels, and the progressive condition is associated with high rates of co-morbidity. This text provides a comprehensive, current state-of-the art review of this field, serving as a valuable resource for primary care providers and non-nephrology clinicians that treat patients with CKD. It is comprised of 24 chapters focused on specific aspects of the disease. The first 2 chapters provide a bit of background on the disease, describing the anatomy and physiology of the kidney as well as the definition and epidemiology of the disease. The following 3 chapters discuss the detection, prevention and progression of the disease. The next 6 chapters describe the relationship of the disease with other conditions and most common co-morbidities such as diabetes and hypertension. The chapters, that follow focus on the CKD associated complications and the CKD within special populations such as the elderly and minorities as well as dietary restrictions and drug dosing. The book concludes with discussion on preparation for renal replacement therapy and preemptive organ transplantation as an alternative to dialysis in the management of the advanced CKD. Written by experts in the field, Approach to Chronic Kidney Disease is a comprehensive guide for clinicians, especially primary care providers including residents and fellows in training, who take care of chronic kidney disease patients. It is also a useful tool for researchers dealing with this challenging field.
Author: M. Priyanthi Kumarasinghe
Publisher: Springer
ISBN: 3319791176
Category : Medical
Languages : en
Pages : 340
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Book Description
The volume of endoscopic biopsies being performed continues to grow rapidly and they now represent one of the most common specimens encountered in routine surgical pathology practice. It is essential to maintain the balance between the speed and accuracy while integrating emerging sophisticated pathology techniques into endoscopic biopsies in routine practice. Microscopic appearance is virtually diagnostic of certain diseases. In others a diagnosis may be rendered only after correlating the microscopic pattern with clinical clues aided by ancillary tests. This text provides a guide to systematic approach of endoscopic biopsies to render a safe, quick and accurate pathological diagnosis in an integrated manner as well as important information that pathologists and clinicians should know to get the best value of endoscopic biopsies. The first chapter introduces the key microscopic features that are normal and abnormal in the gut mucosa as appreciated in an endoscopic biopsy. The second chapter presents a general overview highlighting the neoplastic and non-neoplastic patterns that are common to the entire tubular gut. Because some patterns are common to many sites, an overarching chapter gives the reader a generalized approach, which will be further refined in subsequent site specific chapters. The disease etiologies of each pattern are discussed, with emphasis placed on the most common causes that will be encountered in clinical practice. The subsequent chapters that follow then concentrate on patterns encountered at specific anatomical locations. Under each anatomical location (esophagus, stomach, small intestine and large intestine) site specific patterns of both neoplastic and non-neoplastic conditions are described. Conditions that affect many sites in the gastrointestinal tract are discussed in detail in the most relevant site chapter, but are referred to in other chapters as the reaction pattern/s they produce at that site is discussed. Ancillary tests that are required for a diagnosis of some diseases in particular neoplastic conditions are listed with tips for interpretation. This is presented mostly in a table format to assist day-to-day quick reference. In keeping with recent advances of using small biopsies for testing clinically relevant bio markers, important information that the pathologists and clinicians need to know is highlighted in appropriate sites. Authored by experts in the field, each chapter is presented under headings that include diagnostic features, patterns with relevant endoscopic and clinical clues, traps and overlapping features, and appropriate ancillary tests including clinically relevant molecular signatures in endoscopic biopsies.
Author: Gowraganahalli Jagadeesh
Publisher: Springer
ISBN: 3319159615
Category : Medical
Languages : en
Pages : 1323
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Book Description
The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.
