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Author: Alard van den Bosch
Publisher: Nova Science Publishers
ISBN: 9781620818930
Category : Down syndrome
Languages : en
Pages : 0
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Book Description
Down syndrome (Trisomy 21), is characterised by the presence of an extra chromosome 21, and is the most common chromosomal abnormality. Clinical symptoms of Down syndrome (DS) often include orthopaedic, cardiovascular, neurological, cognitive, perceptual and motor impairments. In this book, the authors present current research from across the globe on Down syndrome. Topics discussed in this compilation include the effects of regular versus special school placement of students with Down syndrome; the clinical association between disorders of the ENS and Down syndrome; the impact of environmental risk factors on maternal meiotic errors; genomic implications of gene dosage imbalance in autosomal trisomy during neural development; parenting stress in families with Down syndrome children; using technology in the evaluation of Down syndrome children's social-cognitive skills; and atypical postural behaviours in individuals with DS.
Author: Alard van den Bosch
Publisher: Nova Science Publishers
ISBN: 9781620818930
Category : Down syndrome
Languages : en
Pages : 0
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Book Description
Down syndrome (Trisomy 21), is characterised by the presence of an extra chromosome 21, and is the most common chromosomal abnormality. Clinical symptoms of Down syndrome (DS) often include orthopaedic, cardiovascular, neurological, cognitive, perceptual and motor impairments. In this book, the authors present current research from across the globe on Down syndrome. Topics discussed in this compilation include the effects of regular versus special school placement of students with Down syndrome; the clinical association between disorders of the ENS and Down syndrome; the impact of environmental risk factors on maternal meiotic errors; genomic implications of gene dosage imbalance in autosomal trisomy during neural development; parenting stress in families with Down syndrome children; using technology in the evaluation of Down syndrome children's social-cognitive skills; and atypical postural behaviours in individuals with DS.
Author: Gert Lubec
Publisher: Springer Science & Business Media
ISBN: 3709167213
Category : Medical
Languages : en
Pages : 241
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Book Description
"Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.
Author: Elizabeth Head
Publisher: Academic Press
ISBN: 0128188464
Category : Medical
Languages : en
Pages : 354
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Book Description
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Author: Subrata Dey
Publisher: BoD – Books on Demand
ISBN: 953513762X
Category : Medical
Languages : en
Pages : 150
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Book Description
This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome.
Author: Sue Buckley
Publisher: DSE Enterprises
ISBN: 1903806038
Category : Children with disabilities
Languages : en
Pages : 46
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Book Description
This book offers an introduction to the development of infants with Down syndrome. Drawing on the latest research and extensive practical experience, it examines many aspects of development during the early years. Presented in an accessible format, it is a useful reference for families and professionals caring for young children with Down syndrome. This introductory book provides an overview of development from birth. It provides information about the development of social, motor, language, cognitive, play, attention, behaviour and self-help skills. It also details typical milestones for children with Down syndrome in these areas. The book highlights the influence of the family and the social interactive nature of development. Individual differences are discussed, as are key health and family issues. Principles for early intervention, therapy and education services are identified, based on the specific needs of children with Down syndrome and research on effectiveness. Down Syndrome Issues and Information is a major series of practical and informative books covering the full range of developmental, health and social issues relating to individuals with Down syndrome. based on years of research and hands-on experience.
Author: David Rhodes
Publisher:
ISBN: 9781632423474
Category : Down syndrome
Languages : en
Pages : 0
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Book Description
This book is an up-to-date handbook in understanding congenital disorders. It enlists state-of-the-art research and analysis on Down Syndrome. Down syndrome is a genetic syndrome involving presence of a third chromosome 21 causing delayed physical growth and sometimes intellectual growth as well. Medical experts, students and professionals will alike find this text extremely handy in their respective fields and they will be able to use this book as a ready reference in their work. The salient characteristics of this book include the common diseases caused by this condition and sheds light on prenatal diagnosis. While it focuses mainly on research work, the utility of this book goes beyond the horizons of academics. It will appeal to an even broader spectrum of readers including families and caretakers of those affected by Down syndrome.
Author:
Publisher: Academic Press
ISBN: 0444642579
Category : Science
Languages : en
Pages : 320
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Book Description
Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more. Presents content by renowned authors who review the state-of-the-art in preclinical research and provide their views and perspectives for the future of the field Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Author:
Publisher: Academic Press
ISBN: 0128184558
Category : Psychology
Languages : en
Pages : 306
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Book Description
State of the Art of Research on Down Syndrome, Volume 56, the latest release in the International Review of Research in Developmental Disabilities series, highlights new advances in the field, with this new volume presenting interesting chapters on the Genetics and Genomics of Down Syndrome, Motor Development and Down Syndrome, Cognitive Profiles in Individuals with Down syndrome, Working Memory and Down syndrome, Environment Learning in Individuals with Down syndrome, Reading for Comprehension: The Contribution of Decoding, Linguistic and Cognitive Skills, Number Sense in Down syndrome, Early Starting States in Infants with Down Syndrome: Implications for Research and Practice, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Research in Developmental Disabilities series Updated release includes the latest information on the State of the Art of Research on Down Syndrome
Author: William I. Cohen
Publisher: John Wiley & Sons
ISBN: 0471418153
Category : Health & Fitness
Languages : en
Pages : 501
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Book Description
Providing a comprehensive survey of the clinical, educational, developmental, psychosocial, and transitional issues relevant to people with Down syndrome, this book addresses the needs of family members, caregivers, and professionals alike. Edited in association with the National Down Syndrome Society, this up-to-date treatment incorporates the newest developments concerning sexuality, inclusion, transition into adulthood, and legislation, as well as a discussion of the Human Genome Project and the sequencing of chromosome 21.
Author: National Institutes National Institutes of Health (NIH)
Publisher: CreateSpace
ISBN: 9781503075337
Category :
Languages : en
Pages : 78
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Book Description
In early 2006, National Institutes of Health (NIH) Director Dr. Elias Zerhouni asked the National Institute of Child Health and Human Development (NICHD) to take the lead in gathering together program scientists from across the NIH to form a Down Syndrome Working Group. The charge to this group was to coordinate ongoing research already supported by the NIH related to Down syndrome, and to enhance new, NIH-supported research efforts based on identification of areas of greatest scientific opportunity, especially as they relate to the development of future treatments. This plan was developed by the Working Group, with input from the outside scientific and family communities, at the request of Congress in the Labor-HHS-Education Appropriations legislation for fiscal year 2007 (see Appendix B), focusing specifically on genetic and neurobiological research relating to the cognitive dysfunction and the progressive late-life dementia associated with Down syndrome. The purpose of the plan is to build upon ongoing NIH-supported research relating to Down syndrome to reflect the changing lives of individuals and families affected, and to take advantage of emerging scientific opportunities. By organizing the research objectives into groupings according to subject area and timeframes, the plan will also serve to apprise the Down syndrome community of NIH's goals for moving ahead in this area, fostering collaborations between NIH and other agencies and groups.
