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Author: Ashfaq A. Marghoob
Publisher: Springer Science & Business Media
ISBN: 3642283969
Category : Medical
Languages : en
Pages : 160
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Book Description
The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Author: Ashfaq A. Marghoob
Publisher: Springer Science & Business Media
ISBN: 3642283969
Category : Medical
Languages : en
Pages : 160
Get Book Here
Book Description
The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Author: Ashfaq A. Marghoob
Publisher: Springer Science & Business Media
ISBN: 3642283977
Category : Medical
Languages : en
Pages : 160
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Book Description
The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
Author: James J. Nordlund
Publisher: John Wiley & Sons
ISBN: 140515733X
Category : Medical
Languages : en
Pages : 1333
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Book Description
The most comprehensive and integrated book on pigmentation The Pigmentary System, Second Edition, gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes. New features of this Second Edition include: Completely new section on the basic science of pigmentation – explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system New chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV All clinical chapters include the latest genetic findings and advances in therapy More than 400 color images of virtually all clinical disorders The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.
Author: Giuseppe Argenziano
Publisher: Elsevier Health Sciences
ISBN: 0323227171
Category : Medical
Languages : en
Pages : 214
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Book Description
Viewing lesions using a dermatoscope helps the dermatologist distinguish between benign and malignant lesions. It is particularly useful in the early diagnosis of melanoma, which is the fastest growing cancer in the US and worldwide. This issue of the Dermatologic Clinics issue all of the important topics in dermoscopy, including differentiation of lesions, lesions in the young and older populations, and dermoscopy in general dermatology.
Author: Victor G. Prieto
Publisher: Springer
ISBN: 1493928619
Category : Medical
Languages : en
Pages : 142
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Book Description
This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases.
Author:
Publisher: ScholarlyEditions
ISBN: 1481647059
Category : Medical
Languages : en
Pages : 166
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Book Description
Issues in Dermatology and Cosmetic Medicine: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Dermatology. The editors have built Issues in Dermatology and Cosmetic Medicine: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dermatology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Dermatology and Cosmetic Medicine: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Kyriakos Orfanidis
Publisher: Linköping University Electronic Press
ISBN: 9179299261
Category :
Languages : en
Pages : 106
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Book Description
Melanoma is a form of cancer that develops in melanocytes. While it represents only 5% of skin malignancies, it is the most aggressive and lethal. Benign proliferation of these cells form the melanocytic nevi. The definitive diagnosis of melanocytic nevi or melanoma lesions is histopathologic. However, it is estimated that a correct diagnosis is established by means of standard skin biopsy in only 83% of the melanocytic lesions; of the remaining cases 8% and 9% are overinterpreted (false positives) and under-interpreted (false negatives), respectively. This underscores the importance of additional diagnostic tests. Since cellular senescence is considered to be a tumor suppressive mechanism, immuno-histochemistry using senescence markers has been suggested for the evaluation of difficult melanocytic lesions; however, the routinely used senescence markers lack the ability to distinguish nevi from melanoma. The general aim of this thesis is therefore to identify novel senescence markers that may aid in melanoma diagnosis. In study I, we established a cellular model with nevus-mimicking characteristics consisting in primary melanocytes that become senescent. Transcriptomic analysis allowed expanding the set of senescence-associated markers that could distinguish nevi from melanoma and identifying tubulin ?-3 as a potential diagnostic marker. Depletion of tubulin ?-3 and pretreatment with tubulin destabilizing drugs in melanocytes and melanoma cells induced a senescence-like phenotype in vitro. In particular, reduced migration capacity and induction of cell cycle arrest in G2/M phase of the cell cycle was demonstrated. In study II, a potential inter-cellular signaling pathway between melanoma cells and stromal fibroblasts, that might facilitate melanoma invasion, was investigated. Ultraviolet (UV) radiation was shown, both in melanoma cells and fibroblasts, to promote the release and activation of TGF-?1 and subsequent increase in expression of the serine protease FAP-?, a protein that plays role in extracellular matrix degradation and therefore facilitates the invasion of melanoma cells. Such mechanism was not functional in senescent melanocytes. In study III, it was shown that tubulin ?-3 immunostaining aids in the diagnosis of nevi and melanomas. The diagnostic criterium was the tubulin ?-3 gradient within the melanocytic nevi that was no longer apparent in melanoma. Different patterns of tubulin ?-3 immunostaining in melanoma were described, dermoscopy-immunohistochemistry associations were found, specific dermoscopic features highlighted, and the prognostic value of this tubulin ?-3 marker was examined. The progression rate in patients whose melanomas had areas with loss of tubulin ?-3 was 4 times higher than in patients without this feature, although statistical significance could not be reached (p=0.06). In conclusion, transcriptomic analysis expanded the set of senescence-associated markers that could distinguish nevi from melanoma and identified tubulin ?-3 as novel immunohistochemistry marker shown to have diagnostic and probably prognostic value. From a mechanistical point of view, ultraviolet radiation was shown to promote not only the formation of melanoma but also its progression by increasing a cathepsin-TGF-?1-FAP-? pathway resulting in extracellular matrix degradation. Malignt melanom är en form av cancer som utvecklas i melanocyter, de celler i huden som bildar pigmentet melanin. Även om malignt melanom endast utgör 5% av alla hudcancrar, är den den mest aggressiva och dödliga. Godartad ansamling av melanocyter bildar en leverfläck eller ett sk nevus. Vid minsta misstanke om melanom, opereras nevuset bort och analyseras i mikroskop. Det uppskattas dock att en korrekt diagnos fastställs endast i 83% av de bortopererade lesionerna. Av de återstående fallen är 8% övertolkade och 9% undertolkade. Detta understryker vikten av att förbättra melanomdiagnostik. Melanocyter i nevi anses i motsats till melanom ha avtagande förmåga att föröka sig efter ett visst antal celldelningar på grund av cellåldrande. Påvisande av cellåldrande-markörer skulle därför kunna förbättra diagnostiken av svårbedömda lesioner. De idag rutinmässigt använda cellåldrande-markörerna saknar dock förmåga att skilja nevi från melanom. Det övergripande syftet med denna avhandling var därför att försöka identifiera nya cellåldrande-markörer för att förbättra melanom-diagnostiken. I studie I etablerade vi en cellmodell med nevus-efterliknande egenskaper bestående av melanocyter som åldras. Med genuttryck-analys studerades cellåldrande-markörer som kunde skilja nevi från melanom. Proteinet tubulin ?-3 identifierades som en potentiell diagnostisk markör. Minskning av tubulin ?-3 och förbehandling med tubulin-destabiliserande läkemedel i melanocyter visade sig inducera ett tillstånd som liknar cellåldrandet. I studie II undersöktes en signalväg mellan melanomceller och fibroblaster, som kan underlätta melanomcellers förmåga att infiltrera och aktivt förstöra omgivande vävnad. Fibroblaster är en typ av bindvävsceller i läderhuden som tillverkar ämnen som finns mellan celler, s.k. extracellulär matrix. Ultraviolett (UV)-strålning visade sig, både i melanomceller och fibroblaster, främja signalvägen som resulterar i ökat proteinuttryck av FAP-?, ett protein som bidrar till nedbrytning av extracellulär matrix vilket kan underlätta infiltration av melanomceller. En sådan signalväg var inte funktionell i åldrande melanocyter. I studie III visade vi att proteinet tubulin ?-3 är en markör som underlättar diagnostik av nevi respektive melanom. Det diagnostiska kriteriet var tubulin ?-3 gradienten som kunde ses i nevi men som ej var synligt i melanom. Olika mönster av tubulin ?-3 analys i melanom beskrevs, kliniska associationer hittades och värdet av denna markör för att förutsäga sjukdomens förlopp undersöktes. Melanompatienter, vars melanom hade områden med förlust av tubulin ?-3, hade fyra gånger högre progressionstakt av sjukdomen jämfört med patienter utan detta mönster. Sammanfattningsvis studerade vi cellåldrande-markörer som kunde skilja nevi från melanom och vi identifierade proteinet tubulin ?-3 som en markör med diagnostiskt och förmodligen prognostiskt värde. Vi visade att ultraviolett strålning inte bara främjar melanombildning utan också dess progression genom att öka en signalväg mellan melanomceller och fibroblaster som resulterar i extracellulär matrixnedbrytning.
Author: Danica Tiodorovic
Publisher: Springer Nature
ISBN: 3030294471
Category : Medical
Languages : en
Pages : 210
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Book Description
This book provides a practical guide to the clinical decision-making process used in the management of skin cancers with the use of dermoscopy. Clinical cases are examined to help the reader through the treatment of unusual skin cancers using best practice techniques. A variety of skin conditions are covered, including melanoma, basal cell carcinoma, squamous cell carcinoma, Bowen’s disease and actinic keratosis. Clinical Cases in Dermoscopy of Skin Cancers highlights evidence-based best practice through its multidisciplinary approach and is an important addition to the literature to help trainees and practicing dermatologists or any healthcare professional who manages these patients.
Author: Salvador Gonzalez
Publisher: CRC Press
ISBN: 1498757626
Category : Medical
Languages : en
Pages : 849
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Book Description
Reflectance confocal microscopy enables lesions in skin to be examined without excision, but with improved diagnostic accuracy, assessment of dermoscopic-histologic correlation, assessment of surgical margins, as well as speed and convenience for the physician and patient. This extensively enlarged and updated text reviews the current and future state of the art for those involved with the diagnosis and treatment of skin tumors, with a greatly increased amount of material on the expected normal patterns of skin throughout life and on non-melanocytic tumors.
Author: Charles M. Balch
Publisher: Springer
ISBN: 9783030050689
Category : Medical
Languages : en
Pages : 0
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Book Description
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
