Neuropharmacology of New Psychoactive Substances (NPS) PDF Download
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Author: Michael H. Baumann
Publisher: Springer
ISBN: 3319524445
Category : Medical
Languages : en
Pages : 380
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Book Description
Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.
Author: Michael H. Baumann
Publisher: Springer
ISBN: 3319524445
Category : Medical
Languages : en
Pages : 380
Get Book Here
Book Description
Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon.
Author: Ornella Corazza
Publisher: Routledge
ISBN: 1351655523
Category : Psychology
Languages : en
Pages : 403
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Book Description
Handbook of Novel Psychoactive Substances (NPS) provides a comprehensive overview of the challenges that clinicians face when dealing with NPS and discusses how the profile of patients and their socio-demographic characteristics frame the serious public health concern that NPS pose. It presents various clinical cases, as well as detailed accounts of symptoms, psychopathology, toxicity, and overall clinical management that NPS require. This handbook brings together a unique collection of chapters written by leading experts in the field, who have felt the need to share their knowledge and experience to improve the clinical practice on NPS and the wellbeing of their patients.
Author: Liana Fattore
Publisher: Frontiers Media SA
ISBN: 2889458644
Category :
Languages : en
Pages : 196
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Book Description
An increasing number of novel psychoactive drugs are currently available and sold as 'legal highs' or 'research chemicals'. These New Psychoactive Substances (NPS) constitute a broad range of hundreds of natural and synthetic drugs, including synthetic cannabinoids, synthetic cathinones, synthetic opioids and other classes, which use has resulted in a significantly growing number of intoxication and mortality, as reported by emergency and poison centres from all over the world. Definition of “NPS” includes any substance that has recently become available and has been designed purposely to replace illegal drugs, although not necessarily of new synthesis. Use of NPS is dramatically increased in the last decade and represents a serious risk for the public health. Their ever-evolving chemical structure, the possibility to distribute in real time through the Internet and social networks information about their use and effects have dramatically challenged public health and drug policies internationally. NPS recently attracted great attention, but most are still unregulated and proposed online as legal alternatives to traditional illicit drugs. Unfortunately, this area is still poorly investigated and very limited information are available so far on their nature and potential risks. The phenomenon of NPS requires multi-national and multi-disciplinary collaborations to improve our knowledge on this changing drug market, to share information and define good practices at a global level. Political and educational efforts are indispensable to regulate this mutable scenario and to inform the public about health consequences of NPS use. Clinicians and emergency staff should be aware that NPS may cause severe health consequences and unexpected adverse effects, and be informed on how to recognized and treat specific intoxication cases. Considering the widespread use of NPS and paucity of information about their toxicology and pharmacology, this Research Topic will be useful to understand the new trends in the scenario of drug use, abuse and addiction to inform professionals and general public about the health problems caused by NPS and to help drug-control policies to adopt suitable control measures.
Author: Hans H. Maurer
Publisher: Springer
ISBN: 303010561X
Category : Medical
Languages : en
Pages : 566
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Book Description
This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.
Author: Eulàlia Olesti Muñoz
Publisher:
ISBN:
Category :
Languages : en
Pages : 230
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Book Description
In the last decade, the rapid emergence of a group of compounds known as novel psychoactive substances (NPS) has become a worrying problem due to their ambiguous legal status, their easy availability, their extensive consumption and their severe adverse effects. NPS are compounds designed to mimic existing established recreational drugs. The most commonly clinically encountered NPS are stimulants (such as mephedrone) and cannabinoids (such as "spice") and our knowledge of their pharmaco-toxicological profile is very limited. The evaluation of hundreds of substances in a short time period is a challenge for public health and drug policies globally. This thesis aims to contribute to the pharmacological evaluation of NPS by developing a targeted metabolomics approach (on neurotransmitters and steroids) applied to brain tissue as well as in plasma and urine as a tool to predict the pharmacological profile of NPS, circumventing limitations of the current evaluation approach. We focused on specific NPS (i.e. cathinones, synthetic cannabinoids) to demonstrate the proof of principle of the methodological approach developed. By using chromatographic techniques coupled to tandem mass spectrometry, the quantification of endogenous and exogenous compounds, presumably altered after drug intake, was achieved in different biological matrices. We studied more in depth the metabolic clearance of mephedrone in humans focusing on its pharmacokinetics and pharmacogenetics aspects regulating its disposition as well as the interactions with its pharmacodynamics in a set of multi-dose randomized double-blind clinical trials. The pharmacological predictions for novel drugs was accomplished by quantifying the neuro-metabolomics fingerprint alterations of NPS compared to those observed after the intake of classical drugs of abuse. In brief, this work has contributed to describe the human disposition of mephedrone and it also highlight the potential of using targeted metabolomics as a tool to predict the pharmacological profile of NPS.
Author: Fabrizio Schifano
Publisher: MDPI
ISBN: 3038975079
Category : Biology (General)
Languages : en
Pages : 199
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Book Description
This book is a printed edition of the Special Issue "Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon" that was published in Brain Sciences
Author: Ornella Corazza
Publisher: Springer
ISBN: 331960600X
Category : Business & Economics
Languages : en
Pages : 192
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Book Description
In light of the recent emergence of Novel Psychoactive Substances (NPS) on a global scale, this book provides a timely analysis of the social and economic impact of the NPS phenomenon, and of the global policy and regulatory responses to it. It presents the first comprehensive overview of the international regulation, policy and market structure of the NPS phenomenon, offering a guide to inform legislative discussions and demonstrating from a comparative perspective the different approaches used to address the rise of NPS to date. It covers topics such as organized crime, drug markets, clinical evidence on NPS, and different regulatory approaches also in less explored settings such as prisons and sport environments. Overall, this highly informative and well-structured repository of different experiences with NPS policy, law and regulation offers an essential primary source of evidence for anyone interested in the area of drug and NPS policy, health economics and p ublic health.
Author: Paul I. Dargan
Publisher: Academic Press
ISBN: 0124159117
Category : Medical
Languages : en
Pages : 438
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Book Description
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. Includes chapters written by international experts in the field. Provides a comprehensive look at the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance. Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies. Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene including mephedrone and the synthetic cannabinoid receptors in ‘spice’ / ‘K2’.
Author: Paul I. Dargan
Publisher: Academic Press
ISBN: 0128190302
Category : Medical
Languages : en
Pages : 556
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Book Description
Novel Psychoactive Substances: Classification, Pharmacology and Toxicology, Second Edition provides readers with a comprehensive examination on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." The book covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance and a discussion of their associated acute and chronic harm and toxicity. This second edition addresses drugs new to the scene, with completely updated and revised chapters. Written by international experts in the field, this multi-authored book is an essential reference for scientists, clinicians, academics, and regulatory and law enforcement professionals. Includes chapters written by international experts in the field Presents a comprehensive overview on the classification, detection, availability and supply of novel psychoactive substances, in addition to the pharmacology and toxicology associated with the substance Offers a single source for all interested parties working in this area, including scientists, academics, clinicians, law enforcement and regulatory agencies Provides a full treatment of novel psychoactive substances that have recently emerged onto the recreational drug scene, including amphetamines and the synthetic cannabinoid receptors in ‘spice’ and ‘K2’
Author: Ornella Corazza
Publisher: Springer
ISBN: 9783319868967
Category : Business & Economics
Languages : en
Pages : 0
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Book Description
In light of the recent emergence of Novel Psychoactive Substances (NPS) on a global scale, this book provides a timely analysis of the social and economic impact of the NPS phenomenon, and of the global policy and regulatory responses to it. It presents the first comprehensive overview of the international regulation, policy and market structure of the NPS phenomenon, offering a guide to inform legislative discussions and demonstrating from a comparative perspective the different approaches used to address the rise of NPS to date. It covers topics such as organized crime, drug markets, clinical evidence on NPS, and different regulatory approaches also in less explored settings such as prisons and sport environments. Overall, this highly informative and well-structured repository of different experiences with NPS policy, law and regulation offers an essential primary source of evidence for anyone interested in the area of drug and NPS policy, health economics and p ublic health.
