Down Syndrome: From Understanding the Neurobiology to Therapy PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Down Syndrome: From Understanding the Neurobiology to Therapy PDF full book. Access full book title Down Syndrome: From Understanding the Neurobiology to Therapy by Mara Dierssen. Download full books in PDF and EPUB format.
Author: Mara Dierssen
Publisher: Elsevier
ISBN: 044454299X
Category : Medical
Languages : en
Pages : 273
Get Book Here
Book Description
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Author: Mara Dierssen
Publisher: Elsevier
ISBN: 044454299X
Category : Medical
Languages : en
Pages : 273
Get Book Here
Book Description
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Author: Marie-Claude Potier
Publisher: Frontiers Media SA
ISBN: 2889450457
Category :
Languages : en
Pages : 183
Get Book Here
Book Description
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.
Author: Robert M. Hodapp
Publisher: Academic Press
ISBN: 0123942845
Category : Education
Languages : en
Pages : 253
Get Book Here
Book Description
International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. Volume 42 of the series offers chapters on a variety of themes. Provides the most recent scholarly research in the study of developmental disabilities A vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers
Author:
Publisher: Academic Press
ISBN: 0128003340
Category : Psychology
Languages : en
Pages : 269
Get Book Here
Book Description
International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. - Provides the most recent scholarly research in the study of developmental disabilities - A vast range of perspectives is offered, and many topics are covered - An excellent resource for academic researchers
Author: Rhonda Faragher
Publisher: Routledge
ISBN: 1134673353
Category : Education
Languages : en
Pages : 281
Get Book Here
Book Description
For individuals with Down syndrome, the extent of the effect of intellectual disability depends largely on the degree of provision of appropriate support and intervention. In Educating Learners with Down Syndrome, editors Rhonda Faragher and Barbara Clarke have brought together a number of expert contributors, whose chapters review recent findings in the field of DS education, highlight promising practices, and identify areas for future research. While the emphasis is primarily on the school years, links to early intervention and to life post-16 are made, with chapters organized into three parts: conceptual overview of issues in learning and teaching, learning mathematics, and literacy development. The book is also united by the cohesive themes of assessment, evidence-based practice, and inclusive practices. Educating Learners with Down Syndrome importantly incorporates the voices of individuals with Down syndrome, whose personal narratives add significance to the research mission of the text and demonstrate the authors' inclusive philosophy. Aimed at researchers, teacher educators, higher degree students, and policy makers, this book is the first of its kind to provide a compendium of research on educating learners with Down syndrome.
Author:
Publisher: Academic Press
ISBN: 0080922694
Category : Medical
Languages : en
Pages : 339
Get Book Here
Book Description
This special issue is among the first volumes to examine the topic of early development in children with neurogenetic disorders associated with intellectual disability. It includes discussions of theoretical issues regarding the emergence of behavioural profiles during early development, as well as comprehensive accounts of early development in specific disorders such as Down syndrome, fragile X syndrome, Williams syndrome, and sex chromosome disorders. In addition, several contributions examine the latest clinical applications of this work for diagnosis, treatment, and education. - The comprehensive nature of the reviews of early development in neurogenetic disorders provided by top researchers in the field of developmental disabilities research - Innovation in the application of new approaches to this population, such dynamic systems theory and the developmental trajectory approach to studying these populations place this volume on the cutting edge of theoretical work in this area - This volume also addresses the implications of emerging behavioural phenotypes in neurogenetic disorders from many angles—the biological issues related to diagnosis, psychiatric issues related to comorbid conditions such as autism and autism spectrum disorder, and educational issues related to targeted intervention
Author: Karen Caplovitz Barrett
Publisher: Psychology Press
ISBN: 1848729197
Category : Education
Languages : en
Pages : 509
Get Book Here
Book Description
Section 1. Development of emotion regulation and self-regulation / section editor: Karen Caplovitz Barrett -- section 2. Development of self-regulation : physiological and brain processes / section editor: Nathan A. Fox -- section 3. Development of self-regulation and mastery motivation / section editor: George A. Morgan -- section 4. Self-regulation in atypical development / section editors: Deborah J. Fidler and Lisa A. Daunhauer.
Author: Bani Bandana Ganguly
Publisher: Academic Press
ISBN: 0323904572
Category : Medical
Languages : en
Pages : 500
Get Book Here
Book Description
Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development. - Reviews genetic etiology and mechanisms of trisomy 21 - Discusses prenatal screening and genetic counseling, including ethical aspects - Explores link between Down Syndrome and susceptibility to Alzheimer's and early brain aging - Covers cognitive and neurological symptoms and other health consequences - Identifies future therapeutic developments
Author: John D. Bonvillian
Publisher: Open Book Publishers
ISBN: 1783749261
Category : Education
Languages : en
Pages : 406
Get Book Here
Book Description
Simplified Signs presents a system of manual sign communication intended for special populations who have had limited success mastering spoken or full sign languages. It is the culmination of over twenty years of research and development by the authors. The Simplified Sign System has been developed and tested for ease of sign comprehension, memorization, and formation by limiting the complexity of the motor skills required to form each sign, and by ensuring that each sign visually resembles the meaning it conveys. Volume 1 outlines the research underpinning and informing the project, and places the Simplified Sign System in a wider context of sign usage, historically and by different populations. Volume 2 presents the lexicon of signs, totalling approximately 1000 signs, each with a clear illustration and a written description of how the sign is formed, as well as a memory aid that connects the sign visually to the meaning that it conveys. While the Simplified Sign System originally was developed to meet the needs of persons with intellectual disabilities, cerebral palsy, autism, or aphasia, it may also assist the communication needs of a wider audience – such as healthcare professionals, aid workers, military personnel , travellers or parents, and children who have not yet mastered spoken language. The system also has been shown to enhance learning for individuals studying a foreign language. Lucid and comprehensive, this work constitutes a valuable resource that will enhance the communicative interactions of many different people, and will be of great interest to researchers and educators alike.
Author: Grace Iarocci
Publisher: SAGE Publications Limited
ISBN: 1526485192
Category : Psychology
Languages : en
Pages : 402
Get Book Here
Book Description
Written by psychologists engaged in research, teaching, and practice, Understanding Intellectual and Developmental Disabilities encourages a nuanced, contextually informed understanding of the development of individuals with developmental disabilities. This accessible book contextualises developmental disability across the lifespan and within social systems. It will help you understand the complex interaction between genetics, environments, and experiences, in relation to specific conditions such as ADHD, autism, foetal alcohol spectrum conditions, and Down syndrome. It also introduces you to the wide range of real-world applications of developmental disabilities research and to some of the current ethical issues around genetic screening and behavioural intervention. Key learning features include: Learning objectives Focus boxes that deliver additional helpful context Chapter summaries Reflective exercises and questions, to test what you’ve learned Recommended videos This book is ideal for students studying atypical development, developmental neuropsychology, and related subjects. Grace Iarocci is Professor of Psychology and the Director of the Autism and Developmental Disabilities Lab at Simon Fraser University Jacob A. Burack is Professor of School/Applied Child Psychology and Human Development at McGill University, Director of the McGill Youth Study Team, and Scientific Director of the Summit Center for Education, Research, and Training Dermot M. Bowler is Professor of Psychology and a founder member of the Autism Research Group at City, University of London
