Author: G. a. Qureshi
Publisher: VSP
ISBN: 9789067642774
Category : Medical
Languages : en
Pages : 880

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Author: Edith V. Sullivan
Publisher: Elsevier
ISBN: 0444626220
Category : Science
Languages : en
Pages : 703

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Book Description
Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. - The first focused reference specifically on alcohol and the brain - Details our current understanding of how alcohol impacts the central nervous system - Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse - Includes section on neuroimaging of neurochemical markers and brain function

Author: Edgar Garcia-Rill
Publisher: Academic Press
ISBN: 0128179937
Category : Medical
Languages : en
Pages : 278

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Book Description
Arousal in Neurological and Psychiatric Diseases focuses on the dysregulation of arousal found in many neurological and psychiatric disorders. Chapters describe the physiology of each process, how it presents in each disorder, and the most appropriate treatment(s). The book also imparts the understanding of the RAS as a system that not only modulates waking, but also survival mechanisms, such as fight vs. flight responses and other reflexes. This book helps neuroscientists, sleep researchers, neurologists and psychiatrists understand the basic mechanisms that modulate arousal in health and disease. In addition, it promotes therapies that can alter the severity and manifestation of multiple disorders. - Provides a comprehensive overview of the basic mechanisms behind dysregulation of arousal in neurological and psychiatric disorders - Describes, in detail, the function of the Reticular Activating System with respect to higher functions, motor control and the intertwining of arousal and motor disorders - Covers multiple neurological disorders, including epilepsy, Alzheimer's disease, Parkinson's disease and autism

Author: Catherine Collin
Publisher: CRC Press
ISBN: 9067644129
Category : Science
Languages : en
Pages : 876

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Book Description
Neuroregulation is a challenging and rapidly developing field that holds the key to many currently intractable medical conditions from nervous and mental diseases to stress-related disorders. Advances in Neuroregulation mirrors the broad scope of research in this area with topics ranging from new concepts on the immune system and on the action of antidepressants to the evolution and development of the autonomic nervous system. In addition, the latest research findings are presented for behavioural disorders and medical conditions such as Parkinson’s disease, Alzheimer’s disease, epilepsy and attention-deficit/hyperactivity disorder. Another area of emphasis is the body's responses to stress and the effect of neuroactive agents in the treatment of stress-related conditions. Many chapters are devoted to the progress being made at the cellular and molecular level, including areas such as: - the conditions for culture of different types of neural cells - conformational diseases and the protein folding problem - vasoactive intestinal polypeptide release from pancreatic islets - the effect of melatonin and corticosterone on macrophages Here, in a book that expands the frontiers of neuroscience, researchers into neuroregulation at the molecular and cellular levels as well as those working at the clinical and systemic levels will find important results relating to their field.

Author: Kenneth Hensley
Publisher: Springer Science & Business Media
ISBN: 1592594247
Category : Medical
Languages : en
Pages : 212

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Book Description
Oxidative damage appears to play a central role in the development of a wide range of tissue pathology, including neurodegenerative disease, drug side-effects, xenobiotic toxicity, carcinogenesis, and the aging process, to name just a few. Because of the centrality of oxidative processes to normal and abnormal tissue function, it has become imperative to develop appropriate analytical techniques to facilitate the quantitation of significant reactants. Without advances in methodology, corresponding advances in our knowledge of underlying biochemical events will be necessarily limited. Drs. Hensley and Floyd have done an outstanding job of assembling the work of world-class experts into Methods in Biological Oxidative Stress. The contributors have presented concise, yet thorough, descriptions of the state-of-the-art methods that any investigator working in the field needs to access. Mannfred A. Hollinger v Preface Free radicals and reactive oxidizing agents were once ignored as biochemical entities not worth close scrutiny, but are now recognized as causes or contributing factors in dozens, if not hundreds, of disease states. In addition, free radical metabolisms of xenobiotics have become increasingly important to pharmacologists. Accordingly, the need has arisen to accurately quantify reactive oxygen species and their byproducts. Methods in Biological Oxidative Stress is practical in scope, providing the details of up-to-date techniques for measuring oxidative stress and detecting oxidizing agents both in vitro and in vivo. The contributors are recognized experts in the field of oxidative stress who have developed novel strategies for studying biological oxidations.

Author: G. Ali Qureshi
Publisher: Elsevier
ISBN: 0080489494
Category : Science
Languages : en
Pages : 795

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Book Description
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Author: P. M. Frossard
Publisher: VSP
ISBN: 9789067643115
Category : Medical
Languages : en
Pages : 284

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Author: Richard G. Cutler
Publisher: World Scientific
ISBN: 9812775730
Category : Family & Relationships
Languages : en
Pages : 872

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Book Description
This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.

Author: Roger Bertolotti
Publisher: VSP
ISBN: 9789067643283
Category : Science
Languages : en
Pages : 576

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Book Description
Gene Therapy is expected to revolutionize the practice of medicine at the turn of the third Millennium. Therapeutic/prophylactic benefits should arise from both gene transfer and gene repair/inactivation protocols devised for patient's somatic cells. Gene expression cassettes, designed for the production of therapeutic proteins and non-coding RNA, are thus experimented together with emerging gene repair/inactivation techniques on a variety of inherited, acquired and infectious/parasitic diseases, including complex neuro-degenerative processes. This book presents a collection of chapters on the main aspects of Gene Therapy, some of which have already been treated in the past, and updates and further develops the current survey. It is aimed at understanding why Human Gene Therapy is likely to be a medical breakthrough, although definitive clinical success still needs time to accomplish. The contributions focus on both technical/biomedical concepts and on experimental/clinical data that appear to confer potential universality to Gene Therapy. This book does not claim to provide an exhaustive review of the pathologies, which are currently approached with Gene Therapy. The presentation of current and emerging approaches, together with problems and tentative issues aims to serve as a booster for the development of new applications in every field of medicine and will, therefore, be of value and interest to researchers in this exciting field.

Author: Gerald Huether
Publisher: Springer Science & Business Media
ISBN: 1461547091
Category : Medical
Languages : en
Pages : 824

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Book Description
This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contri butions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investiga tions through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or industrial applica tions. We offered workshops on tryptophan (in sleep and mood), melatonjn, IDO-acti vation and the eosinophilia-myalgia syndrome (EMS) as a platform for intensive discussion for the participants. In these proceedings many contributions are multidisciplinary and have practical or theoretical implications for different research fields. Hence, we have organized this volume in nine main chapters according to basic disciplines and subjects. We are aware that this classification is artificial, but we hope that it is the best compromise for contributors and readers.