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Author: David K. Stevenson
Publisher: McGraw Hill Professional
ISBN: 0071766758
Category : Medical
Languages : en
Pages : 300
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Book Description
A complete, authoritative guide to the management and treatment of neonatal jaundice Care of the Jaundiced Neonate focuses exclusively on the scientific underpinnings of jaundice, as well as the care of the jaundiced neonate. Edited by three of the field’s most respected neonatal care experts, the book uniquely explains how the imbalance between bilirubin production and elimination leads to jaundice—and that hazardous levels of unconjugated bilirubin can cause kernicterus, or brain damage. In addition, you’ll find the most current and clinically relevant perspectives on the physiology, genetics, and treatment of neonatal jaundice and related hemolytic conditions. FEATURES Covers all aspects of neonatal jaundice—from the biochemistry of bilirubin production to kernicterus Begins with an in-depth examination of the complex gene-environment interactions of bilirubin-induced neurotoxicity and its role in neonatal jaundice Surveys bilirubin production and measurement, its various fractions, and the metabolism and transport of bilirubin Selected chapters highlight the physiology and epidemiology of neonatal unconjugated hyperbilirubinemia; bilirubin toxicity; prevention, screening, and postnatal management; phototherapy and other treatments; and prevention-related public policy. Concluding chapter provides an overview of the key issues surrounding the incidence of neonatal jaundice in low-middle income countries Includes informative review of risk assessment and treatment with phototherapy and other modalities provide key approaches to the effective clinical management of neonatal hyperbilirubinemia
Author: David K. Stevenson
Publisher: McGraw Hill Professional
ISBN: 0071766758
Category : Medical
Languages : en
Pages : 300
Get Book Here
Book Description
A complete, authoritative guide to the management and treatment of neonatal jaundice Care of the Jaundiced Neonate focuses exclusively on the scientific underpinnings of jaundice, as well as the care of the jaundiced neonate. Edited by three of the field’s most respected neonatal care experts, the book uniquely explains how the imbalance between bilirubin production and elimination leads to jaundice—and that hazardous levels of unconjugated bilirubin can cause kernicterus, or brain damage. In addition, you’ll find the most current and clinically relevant perspectives on the physiology, genetics, and treatment of neonatal jaundice and related hemolytic conditions. FEATURES Covers all aspects of neonatal jaundice—from the biochemistry of bilirubin production to kernicterus Begins with an in-depth examination of the complex gene-environment interactions of bilirubin-induced neurotoxicity and its role in neonatal jaundice Surveys bilirubin production and measurement, its various fractions, and the metabolism and transport of bilirubin Selected chapters highlight the physiology and epidemiology of neonatal unconjugated hyperbilirubinemia; bilirubin toxicity; prevention, screening, and postnatal management; phototherapy and other treatments; and prevention-related public policy. Concluding chapter provides an overview of the key issues surrounding the incidence of neonatal jaundice in low-middle income countries Includes informative review of risk assessment and treatment with phototherapy and other modalities provide key approaches to the effective clinical management of neonatal hyperbilirubinemia
Author: Firmino F. Rubaltelli
Publisher: Springer Science & Business Media
ISBN: 1468475177
Category : Medical
Languages : en
Pages : 312
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Book Description
Hyperbilirubinemia of the neonate and the related risk of brain damage with conseguent important alterations in motor development, particularly in sick preterm babies, remains a major problem in nurseries throughout the world. Since its introduction in the 1950's phototherapy has been used for reducing serum bilirubin concentrations in the newborn with hyperbilirubinemia; however, only recently the photoprocesses invoked by light on various substrates including bilirubin have been clari fied in sufficient detail. Light treatment actually exemplifies the intimate relationship between the clinical and basic sciences: the better understanding of the mechanism of phototherapy as a result of investigations initiated in the laboratory has been extended to the bedside as new types of lamps or new schedules of treatment. As a consequence, phototherapy of hyperbilirubinemia has emerged as a well-established branch of photomedicine, based on molecular photo biology, scientific method, and creative use of physics and sophis ticated electrooptical capabilities. The collaboration and exchange of information between workers in different basic and clinical di sciplines is likely to stimulate a further optimization of photo therapy. The purpose of this monograph is to discuss some of the new aspects of bilirubin metabolism and phototherapeutic treatment. Bilirubin conjugation in the fetal and early neonatal life, the mechanism of bilirubin entry into the brain, the measurements of bilirubin concentration in the skin and serum bilirubin binding capacity are discussed by a number of prominent neonatologists.
Author: Frederick J. Suchy
Publisher: Cambridge University Press
ISBN: 1108911374
Category : Medical
Languages : en
Pages : 875
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Book Description
Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Author: Manoj K. Ghoda
Publisher: Springer Nature
ISBN: 9811592314
Category : Medical
Languages : en
Pages : 266
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Book Description
This book is written to simplify complex topics of neonatal and pediatric liver and metabolic diseases which are encountered by clinicians on a day to day basis. Neonatal and early pediatric liver diseases are very much different from adult liver diseases. Most of them are either structural diseases or genetically modulated metabolic disorders affecting liver. They all look same; however the underlying etiology could be quite different. This book thoroughly covers various neonatal and pediatric liver and metabolic diseases through a unique clinical case based approach via a vast clinical experience of the author. The book presents more than 50 unique cases and presents real life learning scenario with various examples facilitating better understanding of the disease and the ways to analyze it. The book uses a simple language and presents line diagrams and algorithms facilitating learning. This book shall be a valuable resource for practicing general pediatricians, pediatric residents and gastroenterologists with involvement in pediatric liver and liver related metabolic diseases.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241548371
Category : Business & Economics
Languages : en
Pages : 442
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Book Description
The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.
Author: Jane Meschan Foy
Publisher:
ISBN: 9781581109665
Category : Children
Languages : en
Pages : 0
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Book Description
The definitive manual of pediatric medicine - completely updated with 75 new chapters and e-book access.
Author: S. Gupta
Publisher: Springer Science & Business Media
ISBN: 9780792387763
Category : Medical
Languages : en
Pages : 386
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Book Description
In recent years there has been an increasing need for transplantation, but the number of donor livers available has increased only slightly, despite intensive public relations activities. New concepts in the field of transplantation, for instance the transplantation of living donor organs or the splitting of organs, are urgently required, to safeguard the treatment of patients with severe liver disease. The development and clinical application of cell therapy for patients with liver disease could soon present a significant enhancement of the therapeutic options. The aim of such cell therapy is to repair or improve the biological function of the chronically and acutely damaged liver. Even though systematic trials are not available, individual case reports and small series already show promising clinical results. Present concepts of cell therapy for liver diseases based on the use of primary hepatocytes have recently been considerably extended through new data on the biology of stem cells. The adult haematopoetic stem cell as a pool for hepatocyte grafts - what would be the perspectives for the clinical application? This book is the proceedings of the Falk Symposium No. 126 on `Hepatocyte Transplantation' (Progress in Gastroenterology and Hepatology Part III) held in Hannover, Germany, October 2-3, 2001, and is a forum for basic research, but also for questions concerning clinical applications in the field of hepatocyte transplantation.
Author: M Jeffrey Maisels
Publisher: CRC Press
ISBN: 9789057026263
Category : Medical
Languages : en
Pages : 228
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Book Description
Jaundice is the most common abnormal physical sign found in the new-born infant. It occurs in around two-thirds of all normal babies in the first few days of life, and can lead to toxicity of the central nervous system. In the current era of cost containment, infants are leaving hospital much earlier and as bilirubin levels are rising at the time of discharge, physicians must now follow these infants as out-patients to make sure that severe jaundice does not occur. Neonatal Jaundice is the first complete source of current information for all physicians interested in the care of the new-born infant. When and how hyperbilirubinemia should be treated is a matter of ongoing controversy and this text presents a reasoned clinical approach to the management of the jaundiced new-born. The editors clearly describe the mechanisms, epidemiology and clinical diagnosis of the condition and review the current therapeutic options which include exchange transfusion, phototherapy and pharmacologic treatment.
Author: David K. Stevenson
Publisher: Elsevier Health Sciences
ISBN: 0323446299
Category : Medical
Languages : en
Pages : 201
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Book Description
Preterm neonates remain at increased risk for adverse bilirubin-related outcomes, including acute bilirubin encephalopathy relative to term infants. Yet, most vulnerable neonates are likely to benefit from the potent anti-oxidant properties of bilirubin. Evidence-based guidelines for the management of hyperbilirubinemia in preterm infants, however, are lacking. High concentrations of unconjugated bilirubin can cause permanent neurologic damage in infants, evident through magnetic resonance imaging of chronic bilirubin encephalopathy or kernicterus. There is a growing concern that exposures to even moderate concentrations of bilirubin may lead to subtle but permanent neurodevelopmental impairment referred to as bilirubin-induced neurologic dysfunction. Our current use of phototherapy to decrease bilirubin loads and its potential photo-oxidant properties is a biological conundrum that has been questioned in the use of phototherapy for very low birth weight neonates. In this issue of Clinics in Perinatology, we provide updates on the current understanding of the biology, mechanisms of increasing bilirubin load due to hemolysis, decreased bilirubin binding capacity and glucose-6-phosphate dehydrogenase deficiency, as well as clinical strategies to operationalize the thresholds for hyperbilirubinemia interventions in preterm infants.
Author: Samir S. Shah
Publisher: McGraw Hill Professional
ISBN: 0071601759
Category : Medical
Languages : en
Pages : 544
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Book Description
A CASE-BASED GUIDE TO PEDIATRIC DIAGNOSIS, CONVENIENTLY ORGANIZED BY PRESENTING SYMPTOMS Symptom-Based Diagnosis in Pediatrics features 19 chapters, each devoted to a common pediatric complaint. Within each chapter, five to eight case presentations teach the diagnostic approach to the symptom. The case presentations follow a consistent outline of History, Physical Examination, and Course of Illness, and are followed by discussion of the Differential Diagnosis, Diagnosis Incidence and Epidemiology, Clinical Manifestations, Diagnostic Approach, and Treatment. Cases are illustrated with vibrant full-color photographs and include numerous tables comparing potential diagnoses. Organized by symptoms--the way patients actually present More than 100 cases teach the diagnostic approach to a symptom Cases illustrate how the same complaint can have a variety of causes Full-color clinical photos and illustrations sharpen your visual diagnosis skills Valuable tables detail the most frequent causes of common symptoms CASE-BASED COVERAGE OF THE SYMPTOMS YOU'RE MOST LIKELY TO ENCOUNTER IN PEDIATRIC PRACTICE Wheezing * Decreased Activity Level * Vomiting * Coughing * Back, Joint, and Extremity Pain * Poor Weight Gain * Abdominal Pain * Altered Mental Status * Rash * Pallor * Fever * Constipation * Neck Swelling * Chest Pain * Jaundice * Abnormal Gait * Diarrhea * Syncope * Seizures Editors Samir S. Shah, MD, MSCE is Director, Division of Hospital Medicine, James M. Ewell Endowed Chair, and Attending Physician in Hospital Medicine & Infectious Diseases at Cincinnati Children’s Hospital Medical Center; and Professor in the Department of Pediatrics at the University of Cincinnati College of Medicine. Stephen Ludwig, MD is Chairman of the Graduate Medical Education Committee and Continuing Medical Education Committee and an attending physician in general pediatrics at The Children's Hospital of Philadelphia; and Emeritus Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.
