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Author: Rassier Dilson J.E
Publisher: Springer Science & Business Media
ISBN: 1441963669
Category : Science
Languages : en
Pages : 360
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Book Description
Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.
Author: Rassier Dilson J.E
Publisher: Springer Science & Business Media
ISBN: 1441963669
Category : Science
Languages : en
Pages : 360
Get Book Here
Book Description
Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.
Author: Dilson Rassier
Publisher: Springer
ISBN: 9781441963673
Category : Science
Languages : en
Pages : 354
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Book Description
Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.
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Publisher: Academic Press
ISBN: 0080957188
Category : Science
Languages : en
Pages : 3533
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Book Description
Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Author: Jean Emile Morel
Publisher: CRC Press
ISBN: 1498725031
Category : Medical
Languages : en
Pages : 342
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Book Description
Thoroughly researched using experimentation and re-examination of all previously published evidence, Molecular and Physiological Mechanisms of Muscle Contraction is a carefully crafted treatise and revision of previous conceptions of muscle contraction. It presents detailed descriptions of new, previously unpublished data and hybrids recent finding
Author: R. John Solaro
Publisher: Springer Science & Business Media
ISBN: 146147678X
Category : Science
Languages : en
Pages : 254
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Book Description
Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.
Author: Bruce M. Carlson
Publisher: Academic Press
ISBN: 0128202793
Category : Science
Languages : en
Pages : 214
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Book Description
Muscle Biology: The Life History of a Muscle looks at the story of a muscle from its embryonic beginnings, through its growth and ability to adapt to changing functional circumstances during adult life, to its eventual decline in both structure and function as old age progresses. Injury occurs to muscle during normal activity, after trauma, and during the source of certain diseases. Chapters on both muscle regeneration and muscle diseases emphasize the possibilities and limitsations of the healing capacity of muscle fibers. Muscle Biology begins with a brief review about the structure and function of a normal mature muscle and then proceeds to follow the developmental history of a muscle from the embryo to old age in a manner that gives the reader a perspective about not only developmental controls but also how at any stage of development a muscle is able to adapt to its functional environment. The book discusses both normal and abnormal changes in the muscle, the mechanisms behind those changes and how to mitigate deleterious changes from disease, 'normal' aging, and disuse/lack of physical activity. This is a must-have reference for students, researchers and practitioners in need of a comprehensive overview of muscle biology. Provides an overview of muscle biology over the course of one’s entire lifespan Explains the important elements of each aspect of muscle biology without drowning the reader in excessive detail Contains over 300 illustrations and includes chapter summaries
Author: Andrew Wood
Publisher: Taylor & Francis
ISBN: 1466552794
Category : Medical
Languages : en
Pages : 759
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Book Description
Physiology, Biophysics and Biomedical Engineering provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It covers the physical phenomena of electricity, pressure, and flow along with the adaptation of the physics of the phenomena to the special conditions and constraints of biolog
Author: Shoichi Imai
Publisher: Springer Science & Business Media
ISBN: 1461555434
Category : Science
Languages : en
Pages : 201
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Book Description
The papers in this volume were contributed by close friends, co-workers and pupils of Professor Setsuro Ebashi. They are dedicated to him to commemorate his great and pioneering contribution to the advancement of muscle physiology and biochemistry, which, in time, exerted a great influence on the whole field of life science. We believe that this issue reveals the present state of research on muscle and/or calcium that was opened up by Professor Ebashi.
Author: Brian R. MacIntosh
Publisher: Human Kinetics
ISBN: 9780736045179
Category : Mechanoreceptors
Languages : en
Pages : 436
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Book Description
Provides readers with a detailed understanding of the different facets of muscle physiology. Examines motoneuron and muscle structure and function. It is intended for those need to know about skeletal muscle--from undergraduate and graduate students gaining advanced knowledge in kinesiology to physiotherapists, physiatrists, and other professionals whose work demands understanding of muscle form and function.
Author: Haruo Sugi
Publisher: Springer Science & Business Media
ISBN: 9780306478703
Category : Muscle cells
Languages : en
Pages : 720
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Book Description
This volume presents the proceedings of a muscle symposium, which was held as the Fourth Fujihara seminar on October 28 - November 1, 2002, at Hakone, Japan. This volume covers all fields of muscle biology, from molecules to humans. This book provides information about recent progress of muscle research as well as the problems that remain to be investigated. This volume will stimulate muscle investigators to design and perform novel experiments to clarify the mysteries in muscle contraction.
