Multiscale Modeling and Homogenization of Reaction-Diffusion Systems Involving Biological Surfaces PDF Download
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Author: Isabella Graf
Publisher: Logos Verlag Berlin GmbH
ISBN: 3832533974
Category : Mathematics
Languages : en
Pages : 288
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Book Description
Many complex chemical processes are responsible for the proper functioning of the human body. A prime example is the finely structured endoplasmic reticulum, which plays an important role in the metabolisms of human cells. To handle mathematical models that account for this fine structure, periodic homogenization methods are derived and applied. Previous results on homogenization of partial differential equations on finely structured manifolds are extended: Using the periodic unfolding method, diffusion terms on manifolds with different scalings with powers of the homogenization parameter, in particular in case of fast diffusion, are homogenized and are applied in three different biological systems: a linear model of carcinogenesis of cells, a nonlinear extension of the linear carcinogenesis model and a model considering T-cell signaling. Simulations and interpretations of the homogeneous T-cell signaling model give an insight into the related biological mechanisms.
Author: Isabella Graf
Publisher: Logos Verlag Berlin GmbH
ISBN: 3832533974
Category : Mathematics
Languages : en
Pages : 288
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Book Description
Many complex chemical processes are responsible for the proper functioning of the human body. A prime example is the finely structured endoplasmic reticulum, which plays an important role in the metabolisms of human cells. To handle mathematical models that account for this fine structure, periodic homogenization methods are derived and applied. Previous results on homogenization of partial differential equations on finely structured manifolds are extended: Using the periodic unfolding method, diffusion terms on manifolds with different scalings with powers of the homogenization parameter, in particular in case of fast diffusion, are homogenized and are applied in three different biological systems: a linear model of carcinogenesis of cells, a nonlinear extension of the linear carcinogenesis model and a model considering T-cell signaling. Simulations and interpretations of the homogeneous T-cell signaling model give an insight into the related biological mechanisms.
Author: Christian Nolde
Publisher: Logos Verlag Berlin GmbH
ISBN: 3832544534
Category : Mathematics
Languages : en
Pages : 98
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Book Description
The use of rigorous numerical methods to approach problems which can not be solved using standard methods (yet) has increased signifiantly in recent years. In this book, riogorous a-posteriori methods are used to study the time evolution of a surface growth model, given by a fourth order semi-linear parabolic partial differential equation, where standard methods fail to verify global uniqueness and smoothness of solutions. Based on an arbitrary numerical approximation, a-posteriori error-analysis is applied in order to prevent a blow up analytically. This is a method that in a similar way also applies to the three dimensional Navier-Stokes equations. The main idea consists of energy-estimates for the error between solution and approximation that yields a scalar differential equation controlling the norm of the error with coefficients depending solely on the numerical data. This allows the solution of the differential equation to be bounded using only numerical data. A key technical tool is a rigorous eigenvalue bound for the nonlinear operator linearized around the numerical approximation. The presented method succeeds to show global uniqueness for relatively large initial conditions, which is demonstrated in many numerical examples.
Author: Martin Jesenko
Publisher: Logos Verlag Berlin GmbH
ISBN: 383254478X
Category : Mathematics
Languages : en
Pages : 156
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Book Description
In the calculus of variations, the goal is to explore extrema of a given integral functional. From origins of the problem, it might be expected that the functional can be adequately simplified by neglecting some small quantities. A way to rigorously justify such an approximation is the Γ-convergence that ensures convergence of corresponding (global) extrema. The main motivation of this work is to investigate properties of doubly indexed integral functionals that Γ-converge for one index fixed. In other words, for two possible approximations we would like to determine whether we may perform them consecutively and if they commute. Our examples are taken from material science with homogenization being one of these two processes. In the first part we are considering a setting related to the elastic regime. However, our assumptions are fairly general and allow for applications in different areas. The second part is devoted to problems in the Hencky plasticity. They are considerably different due to special growth properties of the density.
Author: Weinan E
Publisher: Cambridge University Press
ISBN: 1107096545
Category : Mathematics
Languages : en
Pages : 485
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Book Description
A systematic discussion of the fundamental principles, written by a leading contributor to the field.
Author: Sid M. Becker
Publisher: Academic Press
ISBN: 9780128045954
Category : Medical
Languages : en
Pages : 0
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Book Description
Modeling of Microscale Transport in Biological Processes provides a compendium of recent advances in theoretical and computational modeling of biotransport phenomena at the microscale. The simulation strategies presented range from molecular to continuum models and consider both numerical and exact solution method approaches to coupled systems of equations. The biological processes covered in this book include digestion, molecular transport, microbial swimming, cilia mediated flow, microscale heat transfer, micro-vascular flow, vesicle dynamics, transport through bio-films and bio-membranes, and microscale growth dynamics. The book is written for an advanced academic research audience in the fields of engineering (encompassing biomedical, chemical, biological, mechanical, and electrical), biology and mathematics. Although written for, and by, expert researchers, each chapter provides a strong introductory section to ensure accessibility to readers at all levels.
Author: Erwin Stein
Publisher:
ISBN:
Category : Dynamics
Languages : en
Pages : 870
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Book Description
The Encyclopedia of Computational Mechanics provides a comprehensive collection of knowledge about the theory and practice of computational mechanics.
Author: Yan Wang
Publisher: Woodhead Publishing
ISBN: 0081029411
Category : Technology & Engineering
Languages : en
Pages : 604
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Book Description
Uncertainty Quantification in Multiscale Materials Modeling provides a complete overview of uncertainty quantification (UQ) in computational materials science. It provides practical tools and methods along with examples of their application to problems in materials modeling. UQ methods are applied to various multiscale models ranging from the nanoscale to macroscale. This book presents a thorough synthesis of the state-of-the-art in UQ methods for materials modeling, including Bayesian inference, surrogate modeling, random fields, interval analysis, and sensitivity analysis, providing insight into the unique characteristics of models framed at each scale, as well as common issues in modeling across scales.
Author: P. Suquet
Publisher: Springer
ISBN: 3709126622
Category : Technology & Engineering
Languages : en
Pages : 352
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Book Description
This book presents the most recent progress of fundamental nature made in the new developed field of micromechanics: transformation field analysis, variational bounds for nonlinear composites, higher-order gradients in micromechanical damage models, dynamics of composites, pattern based variational bounds.
Author: Doïna Cioranescu
Publisher: Oxford University Press on Demand
ISBN: 9780198565543
Category : Mathematics
Languages : en
Pages : 262
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Book Description
Composite materials are widely used in industry: well-known examples of this are the superconducting multi-filamentary composites which are used in the composition of optical fibres. Such materials are complicated to model, as different points in the material will have different properties. The mathematical theory of homogenization is designed to deal with this problem, and hence is used to model the behaviour of these important materials. This book provides a self-contained and authoritative introduction to the subject for graduates and researchers in the field.
Author: Alain Goriely
Publisher: Springer
ISBN: 038787710X
Category : Mathematics
Languages : en
Pages : 651
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Book Description
This monograph presents a general mathematical theory for biological growth. It provides both a conceptual and a technical foundation for the understanding and analysis of problems arising in biology and physiology. The theory and methods are illustrated on a wide range of examples and applications. A process of extreme complexity, growth plays a fundamental role in many biological processes and is considered to be the hallmark of life itself. Its description has been one of the fundamental problems of life sciences, but until recently, it has not attracted much attention from mathematicians, physicists, and engineers. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form. The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics. Accordingly, the discussion proceeds in order of complexity and the book is divided into five parts. First, a general introduction on the problem of growth from a historical perspective is given. Then, basic concepts are introduced within the context of growth in filamentary structures. These ideas are then generalized to surfaces and membranes and eventually to the general case of volumetric growth. The book concludes with a discussion of open problems and outstanding challenges. Thoughtfully written and richly illustrated to be accessible to readers of varying interests and background, the text will appeal to life scientists, biophysicists, biomedical engineers, and applied mathematicians alike.
