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Author: Masataka Sata
Publisher: Springer
ISBN: 4431558136
Category : Medical
Languages : en
Pages : 289
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Book Description
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Author: Masataka Sata
Publisher: Springer
ISBN: 4431558136
Category : Medical
Languages : en
Pages : 289
Get Book Here
Book Description
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
Author: Qingbo Xu
Publisher: John Wiley & Sons
ISBN: 0470028785
Category : Science
Languages : en
Pages : 402
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Book Description
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.
Author: Diewertje Ilse Bink
Publisher:
ISBN:
Category :
Languages : en
Pages : 223
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Book Description
Mild cognitive impairment and dementia are common disorders in the elderly. As the life span of the population in the Western world is increasing, the prevalence of cognitive disorders and the social and economic burden that coincide with that will increase. Recent data indicate that cardiovascular diseases are largely associated with an increased risk of dementia. The presence of atherosclerosis, heart failure, hypertension and small vessel disease are all associated with neuropathological changes and increased cognitive decline. Exploring the link between cardiovascular diseases and cognitive decline is important, since it could identify treatment targets for patients with cognitive impairment and dementia. The main hypothesis of this thesis is that different cardiovascular diseases in mice contribute to the development of neuropathological changes related to cognitive impairment and dementia. To test this hypothesis animal models with comparable etiology and neuropathology are needed in order to perform mechanistic studies and study cause-consequence relationships. In chapter 2 we reviewed the literature on mouse models of cardiovascular disease with reported cerebral changes in order to get an insight in which animal models are suited for vascular cognitive impairment or dementia research. These included models for atherosclerosis, heart failure, hypoperfusion, hypertension and small vessel disease. In chapter 3 we explored the distribution of atherosclerotic plaques in the common carotid artery, intracranial carotid artery and circle of Willis in different atherosclerotic mouse models. In chapter 4-6 we used mouse models of atherosclerosis, heart failure and hypoperfusion to study the effect of these cardiovascular diseases on brain pathology.
Author:
Publisher: Academic Press
ISBN: 0128171324
Category : Science
Languages : en
Pages : 284
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Book Description
Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease
Author: Daniel I. Simon
Publisher: Springer Science & Business Media
ISBN: 1592590039
Category : Medical
Languages : en
Pages : 320
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Book Description
A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.
Author: Vicente Andrés
Publisher: Humana
ISBN: 9781493929283
Category : Science
Languages : en
Pages : 0
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Book Description
This volume reviews available mouse models of atherosclerosis, basic aspects of disease initiation and progression, and the visualization of atherosclerotic lesions with invasive and non-invasive techniques that are widely used both in basic research and in the clinic. The chapters catalogue a wide range of in vitro and in vivo experimental methods used for atherosclerosis research, including thorough protocols and valuable notes based on the authors’ personal wet lab experience. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Methods in Mouse Atherosclerosis will be a valuable working guide for researchers performing mouse-based atherosclerosis studies.
Author: David Abraham
Publisher: Springer Science & Business Media
ISBN: 1848826370
Category : Medical
Languages : en
Pages : 448
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Book Description
Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book – Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: “Genetics and Gene Therapy” cover approaches to gene therapy and delivery systems, “Animal Models to Study Vascular Disease” with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Kiyotake Ishikawa
Publisher: Springer Nature
ISBN: 1071638467
Category :
Languages : en
Pages : 261
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Book Description
Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330
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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
