Morphofunctional Aspects of Tumor Microcirculation PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Morphofunctional Aspects of Tumor Microcirculation PDF full book. Access full book title Morphofunctional Aspects of Tumor Microcirculation by Domenico Ribatti. Download full books in PDF and EPUB format.
Author: Domenico Ribatti
Publisher: Springer Science & Business Media
ISBN: 9400749368
Category : Medical
Languages : en
Pages : 122
Get Book Here
Book Description
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.
Author: Domenico Ribatti
Publisher: Springer Science & Business Media
ISBN: 940074935X
Category : Medical
Languages : en
Pages : 122
Get Book Here
Book Description
This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature.
Author:
Publisher: Springer
ISBN: 9789400749375
Category :
Languages : en
Pages : 130
Get Book Here
Book Description
Author: Domenico Ribatti
Publisher: Springer Science & Business Media
ISBN: 9400749368
Category : Medical
Languages : en
Pages : 122
Get Book Here
Book Description
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.
Author: Domenico Ribatti
Publisher: Academic Press
ISBN: 0128113294
Category : Medical
Languages : en
Pages : 184
Get Book Here
Book Description
Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense against pathogens. In addition, the book covers special fields, such as immunohistochemistry, immunogenetics and immunopathology. For the past century, immunology has fascinated and inspired some of the greatest scientists of our time. Numerous Nobel Prizes have been awarded for fundamental discoveries in immunology, from Paul Ehrlich' work on antibodies (1908) to the studies of Zinkernagel and Doherty (1986) elucidating mechanisms of cell-mediated immunity. - Provides on update on developments since the publication of Nobel prize winning research for fundamental discoveries in immunology - Discusses the changing theories and technologies that guided the field - Lists all the important discoveries and books in the field - Explains, in detail, the many Nobel prize-winning contributions of immunologists - Provides recognition of the scientists who were pioneers of landmark discoveries in immunology
Author: Alecsandru Ioan Baba
Publisher:
ISBN: 9789732714577
Category : Electronic books
Languages : en
Pages : 787
Get Book Here
Book Description
Author: Enrico Agabiti-Rosei
Publisher: Springer Nature
ISBN: 3030478017
Category : Medical
Languages : en
Pages : 215
Get Book Here
Book Description
This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1350
Get Book Here
Book Description
Author: Gennady T. Sukhikh
Publisher: Springer
ISBN: 3319750348
Category : Medical
Languages : en
Pages : 334
Get Book Here
Book Description
This richly illustrated book provides a comprehensive overview of the use of current ultrasound techniques, including contrast-enhanced ultrasound and ultrasonic elastography, in the diagnosis of breast disease. The advantages and pitfalls of the various imaging modalities are identified, and it is explained how combined use of the modalities – multiparametric ultrasound – aids diagnosis and in particular assists in the differentiation of benign and malignant disease. Readers will find detailed description and illustration of the imaging appearances of age-related features (including in children and adolescents), the most important benign diseases, different forms of breast cancer, mammary gland pathology in the contexts of pregnancy and female reproductive system disease, chest gland pathology in males, and recurrent and metastatic disease. In addition, ultrasound-guided breast interventions and imaging of breast implants are discussed. Specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons will all find this topical book to be both interesting and helpful in daily clinical practice.
Author: Kwang-Sup Soh
Publisher: Springer Science & Business Media
ISBN: 1461406013
Category : Medical
Languages : en
Pages : 327
Get Book Here
Book Description
Proceedings from the first International Symposium on Primo Vascular System 2010 (ISPS 2010) with special topics on cancer and regeneration was held in Jecheon, Korea during September 17-18, 2010. Includes coverage of new study results that have better revealed the functional aspects of PVS, including its roles in the areas of regenerative medicine and cancer.
Author: Werner A. Kaiser
Publisher: Springer Science & Business Media
ISBN: 3540732926
Category : Medical
Languages : en
Pages : 399
Get Book Here
Book Description
Breast cancer is the leading cause of cancer-related deaths in women, and its prevalence has been steadily rising in recent decades. This book describes morphologic and kinetic signs that are important in the analysis of breast MR images before and after contrast administration and in various pulse sequences. It will help broaden the clinical application of MRM so that as many physicians as possible can make more accurate diagnoses.
