Molecular Quantitative Genetics of Wing Shape in Drosophila Melanogaster PDF Download
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Author: Arnar Pálsson
Publisher:
ISBN:
Category :
Languages : en
Pages : 215
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Book Description
Keywords: relative warp analysis, quantitative trait loci, linkage disequilibrium mapping, microsatellite, evolution.
Author: Arnar Pálsson
Publisher:
ISBN:
Category :
Languages : en
Pages : 215
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Book Description
Keywords: relative warp analysis, quantitative trait loci, linkage disequilibrium mapping, microsatellite, evolution.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Building on quantitative genetic analysis in fruitflies I chose to investigate the molecular genetic underpinnings of natural variation in wing shape. Shape is a complex trait demanding a multidimensional description and was adequately portrayed and quantified with the tools of morphometrics. The results demonstrate uncoupling of size and shape. Shape shows strong degree of integration over the structure, disputing hypothesis of the wing as comprised of independent modules laid down by compartmentalization. However, distinctly local shape effects are also observed in genetic correlations, complementation and association tests, arguing for a continuous distribution along an axis of integration and modularity. The identification of quantitative trait nucleotides within a QTL was pursed in a two step scheme. First I tested a set of candidate loci, implicated by QTL experiments and/or developmental roles, for contribution to wing shape. The results are consistent with segregating variation of loci in the vein-determining pathways, hedgehog (hh), decapentaplegic (dpp) and Epidermal growth factor Receptor (EGFR), impacting shape. The second step involved fine-scale mapping, by testing for associations between EGFR and wing shape in two geographic populations of D. melanogaster. The genotyping was done by sequencing 10.9 kb of the locus from 209 lines demonstrating a mostly neutral locus, possibly experiencing purifying selection. One of two alternate 5'-exons may be evolving more rapidly by positive directional selection. Linkage disequilibrium decays rapidly within EGFR increasing the resolution of association mapping. Association tests identified one site (C31365T) with sex dependent effects on wing size, significant after Bonferroni correction. Seven more sites are weakly suggested. The highest of those (C30200T) disrupts a putative GAGA factor binding element and has replicable effects on crossvein placement in three study designs. The work suggests naturally occurrin.
Author: David Earl Cowley
Publisher:
ISBN:
Category :
Languages : en
Pages : 326
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Author: Dan L. Lindsley
Publisher: Academic Press
ISBN: 0323139841
Category : Science
Languages : en
Pages : 1144
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Book Description
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. - Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature - Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance - Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 - Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges - All maps are reprinted as high-quality foldouts sturdily bound into the volume - Maps may also be purchased separately in an eight-map packet, for laboratory and student use
Author: Petra Zur Lage
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages :
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Author: Petra Zur Lage
Publisher:
ISBN:
Category : Drosophila melanogaster
Languages : en
Pages : 0
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Author: Andrew P. Hendry
Publisher: Springer Science & Business Media
ISBN: 9401005850
Category : Science
Languages : en
Pages : 528
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Book Description
From guppies to Galapagos finches and from adaptive landscapes to haldanes, this compilation of contributed works provides reviews, perspectives, theoretical models, statistical developments, and empirical demonstrations exploring the tempo and mode of microevolution on contemporary to geological time scales. New developments, and reviews, of classic and novel empirical systems demonstrate the strength and diversity of evolutionary processes producing biodiversity within species. Perspectives and theoretical insights expand these empirical observations to explore patterns and mechanisms of microevolution, methods for its quantification, and implications for the evolution of biodiversity on other scales. This diverse assemblage of manuscripts is aimed at professionals, graduate students, and advanced undergraduates who desire a timely synthesis of current knowledge, an illustration of exciting new directions, and a springboard for future investigations in the study of microevolution in the wild.
Author: Dan Wickline
Publisher: Image Comics
ISBN:
Category : Comics & Graphic Novels
Languages : en
Pages : 32
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Book Description
Ray and his coworkers have begun to build their new society, but each newly unfrozen person has their own opinions about what happenedÑand how things should be done.
Author: Benedikt Hallgrímsson
Publisher: Elsevier
ISBN: 0080454461
Category : Science
Languages : en
Pages : 594
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Book Description
Darwin's theory of evolution by natural selection was based on the observation that there is variation between individuals within the same species. This fundamental observation is a central concept in evolutionary biology. However, variation is only rarely treated directly. It has remained peripheral to the study of mechanisms of evolutionary change. The explosion of knowledge in genetics, developmental biology, and the ongoing synthesis of evolutionary and developmental biology has made it possible for us to study the factors that limit, enhance, or structure variation at the level of an animals' physical appearance and behavior. Knowledge of the significance of variability is crucial to this emerging synthesis. Variation situates the role of variability within this broad framework, bringing variation back to the center of the evolutionary stage. - Provides an overview of current thinking on variation in evolutionary biology, functional morphology, and evolutionary developmental biology - Written by a team of leading scholars specializing on the study of variation - Reviews of statistical analysis of variation by leading authorities - Key chapters focus on the role of the study of phenotypic variation for evolutionary, developmental, and post-genomic biology
Author: Donald V. Griffin
Publisher:
ISBN:
Category :
Languages : en
Pages :
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For both experiments, I use fly populations established by Houle et al. that had undergone thirty generations of artificial selection on an index of wing shape. The line-cross analysis suggests that the two lines selected to increase or decrease the wing shape index score had decanalized genetic architectures with respect to their second generation hybrids. This is consistent with the idea that wing shape evolutionary stasis is due, in part, to low evolvability of the trait. The chromosome substitution experiment was hampered by the extinction of over fifty percent of the substitution lines in the experimental design, and so the results had little power to estimate the genetic architecture of the trait. However, the best estimate of the analysis suggests a negative directional epistasis, which is also consistent with the hypothesis that the wings are canalized.
