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Author: Michael Ola Idowu
Publisher: Springer
ISBN: 3319163043
Category : Medical
Languages : en
Pages : 742
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Book Description
Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.
Author: Michael Ola Idowu
Publisher: Springer
ISBN: 3319163043
Category : Medical
Languages : en
Pages : 742
Get Book
Book Description
Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.
Author: Parneet Cheema
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318070750
Category : Medical
Languages : en
Pages : 104
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Book Description
Identifying tumor-specific molecular aberrations via molecular profiling is vital for the use of targeted therapies. Understanding a patient’s unique tumor genetics provides predictive and prognostic information that enables a personalized care plan to be put in place, improving outcomes and minimizing ineffective treatments. 'Fast Facts: Molecular Profiling in Solid Tumors' provides a firm knowledge foundation of somatic molecular profiling methodologies, key information to help with the use of molecular profiling in daily practice and advice on communicating with patients about molecular testing and results. Table of Contents: • Molecular profiling: the basics • Rationale for testing • Sample collection • Test selection and process • Interpreting the report • Talking to patients • Challenges and opportunities
Author: P. Cheema
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318072125
Category : Medical
Languages : en
Pages : 104
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Book Description
Identifying tumor-specific molecular aberrations via molecular profiling is vital for the use of targeted therapies. Understanding a patient’s unique tumor genetics provides predictive and prognostic information that enables a personalized care plan to be put in place, improving outcomes and minimizing ineffective treatments. 'Fast Facts: Molecular Profiling in Solid Tumors' provides a firm knowledge foundation of somatic molecular profiling methodologies, key information to help with the use of molecular profiling in daily practice and advice on communicating with patients about molecular testing and results. Table of Contents: • Molecular profiling: the basics • Rationale for testing • Sample collection • Test selection and process • Interpreting the report • Talking to patients • Challenges and opportunities
Author: Kamla Kant Shukla
Publisher: Springer
ISBN: 981135877X
Category : Medical
Languages : en
Pages : 341
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Book Description
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Author: Fei Dong
Publisher: Elsevier Health Sciences
ISBN: 0323849377
Category : Medical
Languages : en
Pages : 217
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Book Description
In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Author: Debra G. B. Leonard
Publisher:
ISBN: 9780387873664
Category : Cancer
Languages : en
Pages : 285
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Book Description
Author: Fei Dong, MD
Publisher:
ISBN: 9780323849364
Category : Medical
Languages : en
Pages : 240
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Book Description
In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Author: Joseph E. Roulston
Publisher: Springer Science & Business Media
ISBN: 1592597602
Category : Medical
Languages : en
Pages : 389
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Book Description
We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular “fingerprints” that ch- acterize the expression of all known and unknown genes within tumors and their surrounding tissues. More than 30,000 different genes may be measured in each patient’s tumor in a single experiment. Simultaneously, novel therapies that exploit the molecular roadmap have been developed and are now being offered to patients. These novel agents, such as Glivec, Herceptin, Iressa, and others, specifically target individual genes within tumors and can produce d- matic responses in some patients. These drugs are only the forerunners of a coming tidal wave of novel therapeutics that individually target specific m- ecules within cancer cells—more than 300 such agents are currently in phase I or II clinical trials. This is an exciting time for cancer specialists and patients alike. However, if we have learned anything from the past 50 or more years of research into cancer, it is that Lord Beaverbrook, in founding the British national health service in the 1950s, was frighteningly prescient when he defined the primary goal of health care to be “Diagnosis, Diagnosis, Diag- sis. ” Now, more than ever, it is essential that appropriate diagnostic methods and approaches are applied to the selection of patients for treatment.
Author: Pedro Borralho
Publisher: Frontiers Media SA
ISBN: 2832518370
Category : Science
Languages : en
Pages : 279
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Book Description
Author: Mohammad A. Vasef
Publisher: Elsevier Health Sciences
ISBN: 0443112800
Category : Medical
Languages : en
Pages : 1050
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Book Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Providing a clear understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer in an era of personalized medicine, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Molecular Oncology is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, molecular pathologist, oncologist, or pathologist in training as an ideal day-to-day reference or as a reliable learning resource. Provides up-to-date, comprehensive coverage of relevant molecular tests and their clinical applications, along with organ-based chapters on the molecular genetic data relevant to individual disease entities Contains new chapters and substantial revisions to existing content that include updates from the 2022 International Consensus Classification and the WHO Classification of Haematolymphoid Tumours, fifth edition Provides expert guidance on selecting the right test(s) at the right time, as well as comparisons of molecular testing methods (e.g., FISH vs. cytogenetics) Includes current information for new actionable mutations and targeted therapies Covers ultrasensitive molecular techniques for minimal residual disease detection and disease monitoring Discusses circulating cell-free DNA analysis for detection of resistance-associated mutations and disease monitoring, and provides usage details Features an image-rich layout with more than 2,400 print and online-only images, including high-resolution H&E stains, immunostains, FISH images, gross pathology and clinical photographs, detailed full-color medical illustrations, and informative diagrams, charts, and schematics Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Any additional digital ancillary content may publish up to 6 weeks following the publication date Molecular oncology is a rapidly evolving field with tremendous amounts of information that is new since the 2e published in March 2019. There is new molecular genetic data linked to either new targeted therapies or that serves as diagnostic or prognostic indicators. The 3e will include 8-10 new chapters and substantial updates and rewrites to existing contents to make sure ongoing edits and revisions to the upcoming WHO Classification of Hematopoietic Tumors are included in the 3e. The authors provide guidance on selecting the right test(s) at the right time for the right patient and comparisons of molecular testing methods (i.e., FSH testing vs. cytogenetics) are included. The market lacks a definitive source of all the recent changes, and DP3 Molecular Oncology will provide a comprehensive information source.
