Molecular Nanomachines of the Presynaptic Terminal PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Molecular Nanomachines of the Presynaptic Terminal PDF full book. Access full book title Molecular Nanomachines of the Presynaptic Terminal by Silvio O. Rizzoli. Download full books in PDF and EPUB format.
Author: Silvio O. Rizzoli
Publisher: Frontiers Media SA
ISBN: 2889199983
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 114
Get Book Here
Book Description
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.
Author: Silvio O. Rizzoli
Publisher: Frontiers Media SA
ISBN: 2889199983
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 114
Get Book Here
Book Description
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.
Author: Silvio O. Rizzoli
Publisher: Frontiers Media SA
ISBN: 2889764672
Category : Science
Languages : en
Pages : 168
Get Book Here
Book Description
Author: Shaker. A Mousa
Publisher: CRC Press
ISBN: 1000043320
Category : Medical
Languages : en
Pages : 646
Get Book Here
Book Description
The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.
Author: Bhanu P. Jena
Publisher: Springer Nature
ISBN: 3030444961
Category : Science
Languages : en
Pages : 118
Get Book Here
Book Description
In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the “porosome” nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.
Author: Constance Hammond
Publisher: Elsevier
ISBN: 0323986137
Category : Psychology
Languages : en
Pages : 602
Get Book Here
Book Description
Unveiling the latest research in neurophysiology, Cellular and Molecular Neurophysiology, Fifth Edition continues to stand as the only resource in the field. This book remains the standard for those who seek to explore the intricate molecular and cellular physiology of neurons and synapses. Notably, this new edition delves even deeper into the molecular properties and functions of excitable cells, offering unparalleled insights. In this edition, there are two groundbreaking chapters. The first reviews metabotropic receptors for olfactory transduction, while the second presents cutting-edge techniques for neuroscience research. Hypothesis-driven rather than a dry presentation of facts, the content firmly based on numerous experiments performed by top experts in the field, teaches students how to build and conduct intelligent research experiments. This book promotes a true understanding of nerve cell function and will be a useful resource for practicing neurophysiologists, neurobiologists, neurologists, and students in a graduate-level course on the topic alike. - Authoritative foundational coverage of basic cellular and molecular neurophysiology - Includes new chapters on metabotropic olfactory receptors for sensory transduction and experimental techniques used by neurophysiologists
Author: Andrew J. Bean
Publisher: Elsevier
ISBN: 0080465897
Category : Science
Languages : en
Pages : 466
Get Book Here
Book Description
The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. - Provides a comprehensive examination of membrane/protein movement in neuronal function - Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease - Includes a focus on Molecular Mechanisms - Illustrated with color summary pictures - The only book examining protein trafficking and its functional implications, written by leaders in the field
Author: Rafael Yuste
Publisher: Columbia University Press
ISBN: 0231546653
Category : Science
Languages : en
Pages : 482
Get Book Here
Book Description
The human brain is perhaps the most intricate and fascinating object in the known universe. Through a mysterious process, the activity of billions of neurons within a few pounds of matter generates the unfathomable complexity of the mind. This book is a conversational and accessible introduction to the brain. Beginning from basic elements of neuroscience, the acclaimed scientist Rafael Yuste guides readers through increasingly sophisticated topics, developing a unified framework for how the brain functions. He describes how the brain is organized and how it develops, how neurons operate and form neural circuits, and how these circuits function as neural networks to generate behavior and mental states. Yuste challenges the traditional view that the brain is an input-output machine that reacts reflexively to sensory stimuli. Instead, he argues, the purpose of the brain is to make a predictive model of the world in order to anticipate the future and choose successful courses of action. He gives readers insight into the workings of sensory and motor systems and the neurobiological basis of our perceptions, thoughts, emotions, memories, and consciousness. Peppered with anecdotes and illustrated with elegant drawings and diagrams, this succinct and cohesive book is accessible to readers without previous background in the subject. It is written for anyone seeking to grasp the core principles of neuroscience or looking for a fresh and clear perspective on how the brain works.
Author: Virginia M. Pickel
Publisher: Elsevier
ISBN: 0124186823
Category : Medical
Languages : en
Pages : 529
Get Book Here
Book Description
The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. - Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. - Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. - Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. - Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. - A comprehensive reference focused on the structure and function of the synapse - Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease - Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse - Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment
Author: Bruce Alberts
Publisher: Garland Science
ISBN: 1317563751
Category : Science
Languages : en
Pages : 1465
Get Book Here
Book Description
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Author: S. Prasad
Publisher: Alpha Science Int'l Ltd.
ISBN: 9788173195822
Category : Medical
Languages : en
Pages : 338
Get Book Here
Book Description
Presents an account of the remarkable progress made in different areas of neurobiology. This book introduces the structure and development of the brain, showing how they are specialized for the functions they serve. It is concerned with hormones and neurotransmitters.
