Molecular Mechanisms of Protein Export by the Malaria Parasite Plasmodium Falciparum PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Molecular Mechanisms of Protein Export by the Malaria Parasite Plasmodium Falciparum PDF full book. Access full book title Molecular Mechanisms of Protein Export by the Malaria Parasite Plasmodium Falciparum by Bianca Bana. Download full books in PDF and EPUB format.
Author: Bianca Bana
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Bianca Bana
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Neyder Contreras-Puentes
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0
Get Book Here
Book Description
Malaria is a tropical disease of parasitic origin transmitted by the Anopheles mosquito, caused by the protozoan of the genus Plasmodium. Around miles of people worldwide affected by disease, have been related the endemic development of genetic alterations, called erythrocyte polymorphisms. These erythrocyte polymorphisms have become tools for resistance against malaria, where they have had an impact on the appearance of hemoglobinopathies, enzymatic alterations in erythrocytes, and modifications in the structure of erythrocytes related to membrane proteins. These sections address a detailed approach to the resistance mechanisms involved against the development of P. falciparum and develop a complete development of the principles of molecular principles that attempt to explain the functioning of these biochemical mechanisms and the development of the parasite.
Author: Addmore Shonhai
Publisher: Springer Nature
ISBN: 3030783979
Category : Medical
Languages : en
Pages : 256
Get Book Here
Book Description
This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
Author: Brian Michael Malpede
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 147
Get Book Here
Book Description
The malaria parasite Plasmodium utilizes specialized proteins for adherence to cellular receptors in its mosquito vector and human host. Adherence is critical for parasite development, host cell traversal and invasion, and protection from vector and host immune mechanisms. These vital roles have identified several adhesins as vaccine candidates. A deficiency in current adhesin-based vaccines is induction of antibodies targeting non-conserved, non-functional, and decoy epitopes due to the use of full length proteins or binding domains. To alleviate the elicitation of non-inhibitory antibodies, conserved functional regions of proteins must be identified and exploited. Structural biology provides the tools necessary to achieve this goal, and has succeeded in defining biologically functional receptor binding and oligomerization interfaces for a number of promising malaria vaccine candidates. A critical step in the Plasmodium life cycle is adhesion to and invasion of erythrocytes by the merozoite during blood stage growth. The invasion process requires the formation of a tight junction between parasite adhesive proteins and red cell receptors. Formation of this junction allows the merozoite to engage and enter the red cell to form the parasitophorous vacuole. The Erythrocyte-binding-like (EBL) family of cellular adhesion proteins is implicated in the formation of this essential tight junction. Receptor binding by the EBL family of invasion ligands has been localized to a specific portion of each EBL protein designated Region II (RII). This region is composed of the Duffy- binding-like (DBL) domain, unique to Plasmodium species. The two Plasmodium species responsible for the majority of malaria disease in humans are P. falciparum and P. vivax. There are four identified EBL members in P. falciparum that contain two tandem DBL domains in RII. This organization contrasts the single DBL domain in RII of the only characterized EBL member of P. vivax, Duffy-binding Protein (PvDBP). Using a combination of structural, biophysical, and cellular interaction methods we examined the binding mode for these two Plasmodium EBL family members to define the molecular and mechanistic basis of unique red cell invasion routes. Specifically, we sought to enhance our understanding of the molecular and mechanistic details of invasion by Plasmodium EBL ligands with the ultimate goal of identifying novel targets for rational vaccination efforts. We examined receptor interactions of a P. falciparum EBL member, Erythrocyte-binding-antigen 140 (PfEBA-140) and P. vivax DBP to provide insight into invasion by both species of parasite. Our work identified unique interfaces on the DBL domain that provide specific recognition of each ligand's unique red blood cell receptor. Additionally, studies examining oligomeric state identified distinct mechanistic parameters for the two EBL ligands, and contrasted with the mechanism observed for another P. falciparum member, PfEBA-175.
Author: World Health Organization
Publisher:
ISBN: 9789241565721
Category :
Languages : en
Pages : 224
Get Book Here
Book Description
The World Malaria Report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programs and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination, and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal infant and child health the "High Burden to High Impact" approach as well as biological threats to the fight against malaria. The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.
Author: Paolo Mesén-Ramírez
Publisher:
ISBN:
Category :
Languages : en
Pages :
Get Book Here
Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9789241511711
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
The World Malaria Report 2016 summarizes information received from malaria-endemic countries and other sources and updates the analyses presented in the 2015 report. The World Malaria Report is WHO's flagship malaria publication released each year in December. It assesses global and regional malaria trends, highlights progress towards global targets, and describes opportunities and challenges in controling and eliminating the disease. Most of the data presented in this report is for 2015.
Author: Christof Grüring
Publisher:
ISBN: 9783863870553
Category :
Languages : en
Pages : 128
Get Book Here
Book Description
Author: Andrew P. Waters
Publisher: Caister Academic Press Limited
ISBN:
Category : Medical
Languages : en
Pages : 578
Get Book Here
Book Description
The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.
Author:
Publisher: Springer
ISBN: 9781461483250
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
