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Author: Springer
Publisher: Springer
ISBN: 9781468476194
Category :
Languages : en
Pages : 576
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Book Description
Author: Springer
Publisher: Springer
ISBN: 9781468476194
Category :
Languages : en
Pages : 576
Get Book Here
Book Description
Author: Yigal H. Ehrlich
Publisher: Springer Science & Business Media
ISBN: 1468476181
Category : Science
Languages : en
Pages : 553
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Book Description
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Author: Yigal H. Ehrlich
Publisher: Springer
ISBN: 9781468476200
Category : Science
Languages : en
Pages : 563
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Book Description
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Author: Federico Bermudez-Rattoni
Publisher: CRC Press
ISBN: 1420008412
Category : Psychology
Languages : en
Pages : 368
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Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author: Philip Yung-cheng Wang
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Donald W. Pfaff
Publisher: MIT Press
ISBN: 9780262661478
Category : Libido
Languages : en
Pages : 346
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Book Description
What arouses an animal or human from an inactive, nonresponsive state to a condition of activity and responsiveness? What are the biological mechanisms for this change? In this book Donald W. Pfaff focuses on a reproductive behavior typical of many female animals. Sensory stimuli from the male trigger responses in a well-defined circuit of nerve cells. At the top of the circuit, certain nerve cells receive and retain sex hormones such as estrogens and progesterone. As a result, specific genes in these nerve cells are turned on at specific times, affecting in turn the rest of the neural circuit and causing a state of sexual responsiveness. According to Pfaff, the biological bases for the most primitive human drives are largely explained by mechanisms uncovered in animal brains that have not changed in their fundamental properties over millions of years of evolution. Focusing on a single instinctive behavior, in this case the sex drive, is an important step toward understanding the biological reasons for the change from unmotivated to motivated animal behavior.
Author: Yigal H. Ehrlich
Publisher: Springer Science & Business Media
ISBN: 1461548691
Category : Medical
Languages : en
Pages : 229
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Book Description
Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.
Author: Carl Faingold
Publisher: Academic Press
ISBN: 0124158641
Category : Medical
Languages : en
Pages : 537
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Book Description
Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Author: Kjell Fuxe
Publisher: Pergamon
ISBN:
Category : Medical
Languages : en
Pages : 344
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Book Description
Hardbound. This volume represents the state of the art of the understanding of many aspects of neural and humoral communication with focus on molecular mechanisms. The book emphasizes the importance of histochemical techniques such as fluorescence histochemistry, immunocytochemistry and receptor autoradiography together with quantitative neuroanatomy to reach new insight into the functions of the endocrine and the nervous systems. The localization and expression of transmitters and high affinity G protein coupled receptors, especially in relation to monoaminergic and peptidergic transmission, have been analyzed with regard to different modes of neuronal communication, namely wiring transmission and volume transmission within both the autonomic nervous system and the central nervous system. Some of the most advance research on the molecular mechanisms underlying transmitter storage and release and signal transduction at the G protein coupled receptors is p
Author: Heather Ann Mason
Publisher:
ISBN:
Category : Developmental neurobiology
Languages : en
Pages : 298
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Book Description
