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Author: Michael F. Good
Publisher: CRC Press
ISBN: 9780849352584
Category : Medical
Languages : en
Pages : 282
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Book Description
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Author: Michael F. Good
Publisher: CRC Press
ISBN: 9780849352584
Category : Medical
Languages : en
Pages : 282
Get Book Here
Book Description
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Author: Michael Francis Good
Publisher:
ISBN:
Category : Malaria
Languages : en
Pages :
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Book Description
Author: Irwin W Sherman
Publisher: World Scientific
ISBN: 1786340062
Category : Medical
Languages : en
Pages : 278
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Book Description
In 2013, 200 million people were infected with malaria, resulting in over 584,000 deaths, with the potential to affect over half the world's population. Such is the widespread nature of malaria that it is increasingly believed only a vaccine will lead to its eradication.Although the first attempt at a vaccine was made a century ago, it is only in the last 30 years that real progress in testing has been made, in the hope of discovering a molecule that can provide long-lasting protection against the disease. In July 2015, GlaxoSmithKline (GSK) announced that after 30 years of research it had received the green light from the European Medicines Agency for the world's first malaria vaccine, RTS, S, for use in African children aged 6 weeks to 17 months.This book chronicles the development of RTS, S — done in collaboration with the Walter Reed Army Institute for Research, the PATH Malaria Vaccine Initiative (MVI) and funded in part by the Bill and Melinda Gates Foundation — as well as previous candidate vaccines. It also focusses on the continuing quest to find more effective vaccines against this continuing health crisis. Finally, it provides an easily understood background on recombinant DNA and monoclonal antibodies and places them in perspective to their contributions to malaria vaccine development.This book serves as a convenient and easily accessible source of information for students, teachers, microbiologists, parasitologists, physicians, clinicians and research funders.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240057463
Category : Medical
Languages : en
Pages : 77
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Book Description
Preferred product characteristics” (PPCs) are key tools to incentivize and guide the development of urgently needed health products. The PPCs published here aim to articulate the public health need, preferred characteristics, and clinical development considerations for new malaria vaccines. WHO PPCs were initially conceived in 2012-2013 as a class of research-oriented normative guidance documents. The first edition of the WHO PPCs for malaria vaccines (WHO/IVB/14.09), published in 2014, was the first-in-class of these documents. The document published here is an update to the 2014 edition. Since the first malaria vaccine PPCs were published in 2014, major milestones in malaria vaccine R&D have been achieved. In 2021, RTS,S/AS01 became the first malaria vaccine to be recommended by WHO for use in moderate- to high-transmission settings in sub-Saharan Africa. However, a healthy market of vaccines will be needed to meet the global demand. A continued focus on developing new and improved vaccines will be vital in our efforts to reduce global malaria burden and to achieve elimination and eradication. This includes malaria vaccines to prevent blood-stage infection, reduce morbidity and mortality, and/or reduce community-level transmission.
Author: Krishna R. Dronamraju
Publisher: Cambridge University Press
ISBN: 1139451693
Category : Science
Languages : en
Pages : 394
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Book Description
This book, originally published in 2004, is concerned with the links between human evolution and infectious disease. It has long been recognised that an important factor in human evolution has been the struggle against infectious disease and, more recently, it was revealed that complex genetic polymorphisms are the direct result of that struggle.
Author: S. Rajan
Publisher: MJP Publisher
ISBN:
Category : Medical
Languages : en
Pages : 682
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Book Description
PART I GENERAL ASPECTS OF MEDICAL MICROBIOLOGY Introduction and Historical Developments in Microbiology Normal Flora of the Healthy Human Host Non-specific Defence Mechanisms Host–Microbe Interactions Infective Syndrome and Diagnostic Procedure Antimicrobial Chemotherapy Epidemiology and Control of Community Infections Collection of Various Specimens for Diagnosis Selective Cum Differential Media used for the Isolation of Bacteria PART II BACTERIOLOGY General Characteristics of Bacteria Classification of Pathogenic Bacteria Staphylococcal Infections Streptococcal Infections Dental Caries Pneumonia Diphtheria Meningitis Whooping Cough Tuberculosis Leprosy Diarrhoea Cholera Gastroenteritis Typhoid Fever Gonorrhoea Syphilis Gas Gangrene Tetanus Leptospira Borrelia Helicobacter pylori Campylobacter Pseudomonas aeruginosa Chlamydia Rickettsiae Brucella Bacillus anthracis Actinomyces PART III VIROLOGY Characteristic Features of Viruses Classification of Animal Viruses Diagnosis of Viral Infections Smallpox Common Cold Influenza Measles Mumps Rubella Arbovirus Infections Polio Rabies Hepatitis AIDS Herpesvirus Infections Treatment of Viral Infections PART IV MYCOLOGY Introduction to Fungi Mycoses Laboratory Diagnosis of Fungal Infections Superficial Mycoses Subcutaneous Mycoses Systemic Mycoses PART V PARASITOLOGY General Characteristics of Parasites Classification of Pathogenic Protozoa and Helminthes Nematodes Protozoan Infections Nematode Infections Trematode Infections PART VI MYCOPLASMA AND OTHER INFECTIONS Mycoplasma Zoonotic Infections Nosocomial Infections Appendix-I Appendix-II Model Questions Glossary Index
Author: Peter Perlmann
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805573766
Category : Medical
Languages : en
Pages : 422
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Book Description
Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Author: M. Benczur
Publisher: Springer
ISBN: 3642514790
Category : Medical
Languages : en
Pages : 926
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Book Description
At this congress there were again numereous reports of progress in immunology. The new technologies are continuing to have an immense impact: gene isolation, mutation, transfection and expression, protein structure andpeptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomodulation and vaccines. A trmendous mass of data has accumulated over the last years. The reports are up-to-date and outstanding,to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for the years to came, because it is a treasure trove of explorations, making it exciting reading. This progress presents outstanding contributions. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever.
Author: Dmitry I Gabrilovich
Publisher: World Scientific
ISBN: 1783260629
Category : Science
Languages : en
Pages : 378
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Book Description
This is a second edition of the book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been implicated in anti-tumor response. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This book provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration of these cells. It contains unique information on the neutrophil's role in viral infectious diseases and cancer. It also presents the recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases.
Author: Dmitry I Gabrilovich
Publisher: World Scientific
ISBN: 1783262915
Category : Medical
Languages : en
Pages : 447
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Book Description
This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of these cells. Besides that, it contains unique information regarding neutrophils' role in cancer. Finally, this monograph describes recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases./a
