Molecular Genetics of Endometrial Carcinoma PDF Download
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Author: Lora Hedrick Ellenson
Publisher: Springer
ISBN: 3319431390
Category : Medical
Languages : en
Pages : 284
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Book Description
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author: Lora Hedrick Ellenson
Publisher: Springer
ISBN: 3319431390
Category : Medical
Languages : en
Pages : 284
Get Book Here
Book Description
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author: Mansoor R. Mirza
Publisher: Springer
ISBN: 3319645137
Category : Medical
Languages : en
Pages : 317
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Book Description
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
Author: Eric J. Bieber
Publisher: Cambridge University Press
ISBN: 1107040396
Category : Medical
Languages : en
Pages : 1127
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Book Description
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Author: Antonio Simone Laganà
Publisher:
ISBN: 9783036528021
Category :
Languages : en
Pages : 165
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Book Description
Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age to 50% of infertile women. The etiopathogenesis of endometriosis remains controversial--immune, hormonal, genetic, and epigenetic factors may all be involved, and several theories have been proposed to explain it.This book aims to summarize some of the most recent advancements in basic and translational science (immunology, cell biology, genetics, and epigenetics) in the field of endometriosis that may create new scenarios and change our perspective of the topic.
Author: Henry T. Lynch
Publisher: CRC Press
ISBN: 9780849367564
Category : Medical
Languages : en
Pages : 376
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Book Description
This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.
Author: Maria Rosaria Raspollini
Publisher: Cambridge University Press
ISBN: 1107170451
Category : Medical
Languages : en
Pages : 433
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Book Description
This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.
Author: David S. Strayer
Publisher: Lippincott Williams & Wilkins
ISBN: 1496386159
Category : Medical
Languages : en
Pages : 4716
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Book Description
With a simple approach to essential information, Rubin’s Pathology: Mechanisms of Human Disease establishes the foundation for medical training and practice and delivers the perfect balance of basic pathology and bedside perspective to confidently and efficiently equip students for clinical success. More accessible than ever, this eighth edition emphasizes the coverage students need most—disease mechanisms, integration of mechanisms into organ system pathology, and application of pathobiology to diagnostic medicine—in an approachable format with systems-based instruction techniques in mind. Comprehensively revised and updated content reflects the latest approaches to pathology from global leaders in the field and ensures a clinically relevant understanding of key pathology competencies.
Author: Virgil Craig Jordan
Publisher: Univ of Wisconsin Press
ISBN: 9780299140700
Category : Health & Fitness
Languages : en
Pages : 320
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Book Description
During the past twenty years tamoxifen has become the most widely prescribed and most successful drug used in the treatment of breast cancer. In this volume, editor V. Craig Jordan provides articles that trace the development, pharmacology, and clinical research surrounding this drug which, by the year 2000, could be used to treat as many as one million women annually. Drawing from research conducted by specialists in the United States, the United Kingdom, and Italy, the series of articles describes the clinical testing of tamoxifen, highlighting the benefits. Studies show that tamoxifen lowers cholesterol and can potentially protect women against osteoporosis and fatal coronary heart disease. Equally important is a discussion of side effects and possible drug interactions and how these issues relate to patient concerns. An investigation of the development of a new class of drugs for use after tamoxifen fails provides valuable insight into future treatments, as the contributers consider possible resistance to tamoxifen. This volume provides invaluable information for physicians and surgeons who care for patients with breast cancer and for women interested in exploring this therapeutic dimension.
Author: Yuri E. Nikiforov
Publisher: Lippincott Williams & Wilkins
ISBN: 1451114559
Category : Medical
Languages : en
Pages : 451
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Book Description
Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.
Author: Kamla Kant Shukla
Publisher: Springer
ISBN: 981135877X
Category : Medical
Languages : en
Pages : 339
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Book Description
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
