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Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 042996742X
Category : Science
Languages : en
Pages : 328
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Book Description
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 042996742X
Category : Science
Languages : en
Pages : 328
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Book Description
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 0429978502
Category : Science
Languages : en
Pages : 242
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Book Description
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
Author: Perelson
Publisher:
ISBN: 9789780201524
Category :
Languages : en
Pages :
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Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309465184
Category : Technology & Engineering
Languages : en
Pages : 189
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Book Description
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Author: Stuart A. Kauffman
Publisher: Oxford University Press
ISBN: 0199826676
Category : Science
Languages : en
Pages : 958
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Book Description
Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.
Author: Jason B. Wolf
Publisher: Oxford University Press, USA
ISBN: 9780195128062
Category : Science
Languages : en
Pages : 348
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Book Description
Over the last two decades, research into epistasis has seen explosive growth and has moved the focus of research in evolutionary genetics from a traditional additive approach. We now know the effects of genes are rarely independent, and to reach a fuller understanding of the process of evolution we need to look at gene interactions as well as gene-environment interactions. This book is an overview of non-additive evolutionary genetics, integrating all work to date on all levels of evolutionary investigation of the importance of epistasis in the evolutionary process in general. It includes a historical perspective on this emerging field, in-depth discussion of terminology, discussions of the effects of epistasis at several different levels of biological organization and combinations of theoretical and experimental approaches to analysis.
Author: Erik Svensson
Publisher: Oxford University Press
ISBN: 0199595372
Category : Science
Languages : en
Pages : 338
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Book Description
The 'Adaptive Landscape' has been a central concept in population genetics and evolutionary biology since this powerful metaphor was first formulated in 1932. This volume brings together historians of science, philosophers, ecologists, and evolutionary biologists, to discuss the state of the art from several different perspectives.
Author: Harold J. Morowitz
Publisher: Routledge
ISBN: 0429972393
Category : Psychology
Languages : en
Pages : 395
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Book Description
Based upon a conference held in May 1993, this book discusses the intersection of neurobiology, cognitive psychology and computational approaches to cognition.
Author: Leila Kallel
Publisher: Springer Science & Business Media
ISBN: 366204448X
Category : Computers
Languages : en
Pages : 495
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Book Description
During the first week of September 1999, the Second EvoNet Summer School on Theoretical Aspects of Evolutionary Computing was held at the Middelheim cam pus of the University of Antwerp, Belgium. Originally intended as a small get together of PhD students interested in the theory of evolutionary computing, the summer school grew to become a successful combination of a four-day workshop with over twenty researchers in the field and a two-day lecture series open to a wider audience. This book is based on the lectures and workshop contributions of this summer school. Its first part consists of tutorial papers which introduce the reader to a num ber of important directions in the theory of evolutionary computing. The tutorials are at graduate level andassume only a basic backgroundin mathematics and com puter science. No prior knowledge ofevolutionary computing or its theory is nec essary. The second part of the book consists of technical papers, selected from the workshop contributions. A number of them build on the material of the tutorials, exploring the theory to research level. Other technical papers may require a visit to the library.
Author: Stuart A. Kauffman
Publisher:
ISBN: 9780195079517
Category : Medical
Languages : en
Pages : 744
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Book Description
This monograph extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. It explains how complex systems, contrary to expectations, can spontaneously exhibit degrees of order.
