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Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 042996742X
Category : Science
Languages : en
Pages : 328
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Book Description
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
Author: Alan S. Perelson
Publisher: CRC Press
ISBN: 042996742X
Category : Science
Languages : en
Pages : 328
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Book Description
This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.
Author: Perelson
Publisher:
ISBN: 9789780201524
Category :
Languages : en
Pages :
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Book Description
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309465184
Category : Technology & Engineering
Languages : en
Pages : 189
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Book Description
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Author: Jason B. Wolf
Publisher: Oxford University Press, USA
ISBN: 9780195128062
Category : Science
Languages : en
Pages : 348
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Book Description
Over the last two decades, research into epistasis has seen explosive growth and has moved the focus of research in evolutionary genetics from a traditional additive approach. We now know the effects of genes are rarely independent, and to reach a fuller understanding of the process of evolution we need to look at gene interactions as well as gene-environment interactions. This book is an overview of non-additive evolutionary genetics, integrating all work to date on all levels of evolutionary investigation of the importance of epistasis in the evolutionary process in general. It includes a historical perspective on this emerging field, in-depth discussion of terminology, discussions of the effects of epistasis at several different levels of biological organization and combinations of theoretical and experimental approaches to analysis.
Author: Stuart A. Kauffman
Publisher: Oxford University Press
ISBN: 0199826676
Category : Science
Languages : en
Pages : 958
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Book Description
Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.
Author: Erik Svensson
Publisher: Oxford University Press
ISBN: 0199595372
Category : Science
Languages : en
Pages : 338
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Book Description
The 'Adaptive Landscape' has been a central concept in population genetics and evolutionary biology since this powerful metaphor was first formulated in 1932. This volume brings together historians of science, philosophers, ecologists, and evolutionary biologists, to discuss the state of the art from several different perspectives.
Author: Ashish Ghosh
Publisher: Springer Science & Business Media
ISBN: 3642189652
Category : Computers
Languages : en
Pages : 1001
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Book Description
This book provides a collection of fourty articles containing new material on both theoretical aspects of Evolutionary Computing (EC), and demonstrating the usefulness/success of it for various kinds of large-scale real world problems. Around 23 articles deal with various theoretical aspects of EC and 17 articles demonstrate the success of EC methodologies. These articles are written by leading experts of the field from different countries all over the world.
Author: James Patrick Crutchfield
Publisher: Oxford University Press, USA
ISBN: 9780195142655
Category : Mathematics
Languages : en
Pages : 492
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Book Description
The 14 chapters of this volume, which present an overview of new research in evolutionary dynamics, were first presented at a conference held in October 1998 at the Santa Fe Institute. The main divisions of the book are macroevolution; epochal evolution; population genetics, dynamics, and optimization; and evolution of cooperation. Individual topics include spectral landscape theory, external triggers in biological evolution, and evolutionary dynamics of asexual reproduction. Several of the contributors, like the editors, are affiliated with the Sante Fe Institute; others teach or work in physics, genetics, biology, computational neuroscience, and theoretical chemistry at universities and private institutions in the US, UK, Austria, Sweden, Australia, Israel, and Germany. Annotation copyrighted by Book News, Inc., Portland, OR
Author: John Rundle
Publisher: Routledge
ISBN: 0429972172
Category : Social Science
Languages : en
Pages : 322
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Book Description
Within the past five years, the international community has recognized that it may be possible, through programs of systematic study, to devise means to reduce and mitigate the occurrence of a variety of devastating natural hazards. Among these disasters are earthquakes, volcanic eruptions, floods, and landslides. The importance of these studies is underscored by the fact that within fifty years, more than a third of the world’s population will live in seismically and volcanically active zones. The International Council of Scientific Unions, together with UNESCO and the World Bank, have therefore endorsed the 1990s as the International Decade of Natural Disaster Reduction (IDNDR), and are planning a variety of programs to address problems related to the predictability and mitigation of these disasters, particularly in third-world countries. Parallel programs have begun in a number of U.S. agencies.
Author: Alan S Perelson
Publisher: Westview Press
ISBN:
Category : Juvenile Nonfiction
Languages : en
Pages : 344
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Book Description
