Molecular Evolution of the Major Histocompatibility Complex PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Molecular Evolution of the Major Histocompatibility Complex PDF full book. Access full book title Molecular Evolution of the Major Histocompatibility Complex by Jan Klein. Download full books in PDF and EPUB format.
Author: Jan Klein
Publisher: Springer Science & Business Media
ISBN: 364284622X
Category : Medical
Languages : en
Pages : 506
Get Book Here
Book Description
From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.
Author: Jan Klein
Publisher: Springer Science & Business Media
ISBN: 364284622X
Category : Medical
Languages : en
Pages : 506
Get Book Here
Book Description
From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.
Author: M. Kasahara
Publisher: Springer Science & Business Media
ISBN: 4431658688
Category : Medical
Languages : en
Pages : 574
Get Book Here
Book Description
Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi zation of the MHC in humans and other model vertebrates, MHC-parasite co evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen eral.
Author: Mary Kathleen Kuhner
Publisher:
ISBN:
Category :
Languages : en
Pages : 320
Get Book Here
Book Description
Author: Jann Thorsten Martinsohn
Publisher:
ISBN:
Category :
Languages : en
Pages : 350
Get Book Here
Book Description
Author: Antoine Blancher
Publisher: Springer Science & Business Media
ISBN: 3642590861
Category : Medical
Languages : en
Pages : 578
Get Book Here
Book Description
Zoologists have categorized primates into a single order, and no one doubts today that they share a common ancestry. Humans and Old and New World non human primate species, from the lemurs of Madagascar to the African anthro poid apes, represent diverging branches of an evolutionary common trunk. Along with species-specific characters, all primates have retained a number of ancestral traits, relics of their common origin. The comparative study of these species-specific and ancestral traits makes it possible to reconstruct the evolu tionary pathways of humans and nonhuman primates. The discovery of the human blood groups and, later, of the Major Histocom patibility Complex (MHC) had a seminal effect on the field of human genetics, providing the first sound examples of mendel ian polymorphisms. The use of blood group and MHC alleles as genetic markers in biological anthropology gen erated a conceptual revolution and persuaded researchers to begin to think in terms of populations and not only intems of typology. The counterparts of these human red and white cell antigens were found and studied in nunhuman primates, and progress in this field is summarized in this book.
Author: David Heine Bos
Publisher:
ISBN:
Category : Major histocompatibility complex
Languages : en
Pages : 328
Get Book Here
Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
Get Book Here
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Michael T. Clegg
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 352
Get Book Here
Book Description
This multifaceted volume examines the processes that govern genetic change. It captures the synthetic nature of molecular evolution and underscores the problems and recent research efforts made in the field. There are exciting discussions on the rates and processes that govern the evolution of genes and gene families, with special attention given to the evolution of immune system genes. Also covers the evolution of genomes, broken down into four broad categories: plant organelle genomes; the processes that govern tranposon evolution; molecular diversity within the species; and molecular adaptations in natural populations.
Author: Theodore Lee Garber
Publisher:
ISBN:
Category : Major histocompatibility complex
Languages : en
Pages : 154
Get Book Here
Book Description
Author: Vernon Bryson
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 664
Get Book Here
Book Description
Details new perspectives of structural and functional features of proteins and nucleic acids in biochemistry.
