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Author: Colin R. Harwood
Publisher: Wiley
ISBN: 9780471923930
Category : Science
Languages : en
Pages : 618
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Book Description
Molecular Biological Methods for Bacillus Edited by C. R. Harwood, Department of Microbiology, University of Newcastle upon Tyne, UK and S. M. Cutting, The Biological Laboratories, Harvard University, USA This volume represents the first major attempt to produce a compendium of the experimental methods used for the analysis of Bacillus, one of the most important procaryotic genera. Since the pioneering work on the transformation and genetic analysis of Bacillus subtilis by John Spizizen and his colleagues in the late 1950s this microorganism has been extensively studied and is now one of the best understood. More than forty of the world’s leading researchers in the field have generously contributed experimental procedures—devised and used in their laboratories—to this book. The aim throughout has been to present methods as simple step-by-step protocols which have been thoroughly tried and tested. The context in which the methods are used is discussed in detail and relevant information provided on the physiology and genetics of Bacillus. In addition valuable support is provided in the form of troubleshooting tips and advice on safety, the preparation of reagents, and the use of equipment. The book will be invaluable to those working with the genus Bacillus and related genera—both established researchers and those wishing to use this important microorganism for the first time.
Author: Colin R. Harwood
Publisher: Wiley
ISBN: 9780471923930
Category : Science
Languages : en
Pages : 618
Get Book Here
Book Description
Molecular Biological Methods for Bacillus Edited by C. R. Harwood, Department of Microbiology, University of Newcastle upon Tyne, UK and S. M. Cutting, The Biological Laboratories, Harvard University, USA This volume represents the first major attempt to produce a compendium of the experimental methods used for the analysis of Bacillus, one of the most important procaryotic genera. Since the pioneering work on the transformation and genetic analysis of Bacillus subtilis by John Spizizen and his colleagues in the late 1950s this microorganism has been extensively studied and is now one of the best understood. More than forty of the world’s leading researchers in the field have generously contributed experimental procedures—devised and used in their laboratories—to this book. The aim throughout has been to present methods as simple step-by-step protocols which have been thoroughly tried and tested. The context in which the methods are used is discussed in detail and relevant information provided on the physiology and genetics of Bacillus. In addition valuable support is provided in the form of troubleshooting tips and advice on safety, the preparation of reagents, and the use of equipment. The book will be invaluable to those working with the genus Bacillus and related genera—both established researchers and those wishing to use this important microorganism for the first time.
Author: Barbara H. Iglewski
Publisher: Elsevier
ISBN: 0323148670
Category : Science
Languages : en
Pages : 486
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Book Description
Molecular Basis of Bacterial Pathogenesis focuses on the molecular mechanism of disease associated with bacterial pathogens. Topics covered include the population genetics of bacterial pathogenesis; environmental modulation of gene expression in gram-negative pathogens; and bacterial invasion and intracellular growth. Bacterial toxins are also discussed. This volume is comprised of 20 chapters and begins with an overview of pathogenesis, paying particular attention to common elements and genetic mechanisms of regulation. The discovery that many bacterial pathogens are clonal, with individual clones often having a greater virulence than others, is then considered. The next section deals with the regulation of synthesis of surface components and their role in colonization of the host and/or evasion of the host immune defense systems; antigenic variation and its role in evasion of the host immune response; and the role of iron acquisition systems in the colonization of the host. Subsequent chapters explore the invasion and intracellular growth of facultative and obligate intracellular parasites. The last section is devoted to studies on the role of bacterial toxic products in pathogenesis. Bacterial lipopolysaccharides (endotoxins) and exotoxins are described. This book should be of interest to molecular biologists, physiologists, clinical specialists, pathologists, and geneticists.
Author: Edward Schwartz
Publisher: Springer Science & Business Media
ISBN: 3540854673
Category : Science
Languages : en
Pages : 348
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Book Description
Megaplasmids are extrachromosomal genetic elements in the size range of 100 kb and larger. They are found in physiologically and phylogenetically diverse groups of bacteria and archaea. By definition, megaplasmids are not essential for the viability of their hosts under all growth conditions, but paradoxically many megaplasmids carry the genetic information for the defining and characteristic traits of the organism in which they reside. Microbial Megaplasmids reviews our knowledge of the extensively studied representatives, such as the catabolic plasmids of the pseudomonads, the rhizobial Sym plasmids, the Ti plasmids of the genus Agrobacterium and the giant enterobacterial virulence plasmids. It also presents snapshots of more recently discovered megaplasmids. The contribution of megaplasmids to the biology of their hosts is described, highlighting the interactions between megaplasmid and chromosomal genes.
Author: Y. H. Hui
Publisher: John Wiley & Sons
ISBN: 9780471185703
Category : Science
Languages : en
Pages : 956
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Book Description
This handbook discusses how microorganisms (bacteria, fungi, yeasts) can be modified to various extents by means of molecular genetics or genetic engineering. Compiled and written by the world's leading experts and practioners in food science and food technology, it presents the latest research and development in the discipline. It is easy-to-understand and can be used directly by readers interested in practical and commercial applications. So this book is important for researchers as a reference guide, and it can be used in various disciplines as microbiology, chemistry, biochemistry and engineering. 'Food Biotechnology' also is interesting for the industries, in addition to food processing, because commercial products and services affected include fine chemicals, enzymes, cultures, equipment and supplies.
Author: Shmuel Razin
Publisher: Springer Science & Business Media
ISBN: 0306476061
Category : Science
Languages : en
Pages : 574
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Book Description
was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology.
Author: Sang Yup Lee
Publisher: John Wiley & Sons
ISBN: 352782345X
Category : Science
Languages : en
Pages : 1075
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Book Description
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Author: Keith Wilson
Publisher: Cambridge University Press
ISBN: 0521516358
Category : Medical
Languages : en
Pages : 769
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Book Description
Uniquely integrates the theory and practice of key experimental techniques for bioscience undergraduates. Now includes drug discovery and clinical biochemistry.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Category : Science
Languages : en
Pages : 570
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Book Description
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Christoph Wittmann
Publisher: John Wiley & Sons
ISBN: 352734179X
Category : Science
Languages : en
Pages : 789
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Book Description
The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.
Author: Moselio Schaechter
Publisher: Elsevier
ISBN: 008047246X
Category : Science
Languages : en
Pages : 1176
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Book Description
The Desk Encyclopedia of Microbiology aims to provide an affordable and ready access to a large variety of microbiological topics within one set of covers. This handy desk-top reference brings together an outstanding collection of work by the top scientists in the field. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field.* Provides a broad, easily accessible perspective on a wide range of microbiological topics* A synthesis of the broadest topics from the comprehensive and multi-volumed Encyclopedia of Microbiology, Second Edition * Helpful resource in preparing for lectures, writing reports, or drafting grant applications
