Molecular and Genetic Analysis of Lin-29, a Heterochronic Gene Controlling Hypodermal Cell Fate in C. Elegans PDF Download
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Author: Andrew Alan Papp
Publisher:
ISBN:
Category : Caenorhabditis elegans
Languages : en
Pages : 288
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Author: Andrew Alan Papp
Publisher:
ISBN:
Category : Caenorhabditis elegans
Languages : en
Pages : 288
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Book Description
Author:
Publisher: Academic Press
ISBN: 9780123969682
Category : Science
Languages : en
Pages : 0
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Book Description
This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.
Author: David Taylor Harris
Publisher:
ISBN:
Category :
Languages : en
Pages : 165
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Most animals pass through a series of juvenile stages on their way from embryo to adult. These stages represent periods of time in which stage-specific developmental processes occur. At the end of development, the organism transitions from a juvenile state to a mature adult. The failure to undergo a specific developmental stage, or the failure to transition to an adult can lead to specific developmental deficits or the retention of juvenile characteristics throughout the remainder of the organism's life. This thesis focuses on the study of the mechanisms controlling the larval-to-adult transition in C. elegans. In Chapter two, I perform a screen to identify mutants that are defective in a specific aspect of the larval-to-adult transition, exit from the molting cycle. From this screen I identify new alleles of the previously identified gene mab-10. I then clone mab-10, showing that it encodes the only C. elegans NAB family transcriptional cofactor. I go on to show that MAB- 10 acts with LIN-29 to control the larval-to-adult transition and that LIN-29 shares homology with mammalian EGR proteins. These observations highlight the similarity between the mechanisms controlling the onset of adulthood in C. elegans and mammals as LIN-29 is required for the larval-to-adult transition in C elegans and EGRI is required for the onset of puberty in mice. Chapter three is a further analysis of both mab-10 and lin-29, focusing on their expression patterns and roles in the terminal differentiation of tissues outside of the hypoderm. We use a mab-10 translational reporter to show that MAB-10 accumulates precociously in precocious heterochronic mutants and that mab-10 transcription does not require lin-29, suggesting that the heterochronic pathway controls the timing of mab-10 transcription in parallel to lin-29. We use single molecule fluorescence in situ hybridization to establish the wild-type transcription patterns of mab-10 and lin-29 and show that both undergo dynamic changes in expression throughout development. We show that mab-10 is required for terminal differentiation in at least one other tissue outside of the hypoderm and that mab-10 prevents seam cell overproliferation by antagonizing the activities of the C. elegans Runx and CBF-Beta homologs rnt-1 and bro-1.
Author: Jill Canaday Bettinger
Publisher:
ISBN:
Category :
Languages : en
Pages : 480
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 924
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Author: Yang Hong
Publisher:
ISBN:
Category : Caenorhabditis elegans
Languages : en
Pages : 240
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Author: Juan E. Abrahante Lloréns
Publisher:
ISBN:
Category :
Languages : en
Pages : 406
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Author: Michael L. McKinney
Publisher: Springer Science & Business Media
ISBN: 1489907955
Category : Science
Languages : en
Pages : 353
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... an adult poet is simply an individual in a state of arrested development-in brief, a sort of moron. Just as all of us, in utero, pass through a stage in which we are tadpoles, ... so all of us pass through a state, in our nonage, when we are poets. A youth of seventeen who is not a poet is simply a donkey: his development has been arrested even anterior to that of the tadpole. But a man of fifty who still writes poetry is either an unfortunate who has never developed, intellectually, beyond his teens, or a conscious buffoon who pretends to be something he isn't-something far younger and juicier than he actually is. -H. 1. Mencken, High and Ghostly Matters, Prejudices: Fourth Series (1924) Where would evolution be, Without this thing, heterochrony? -M. L. McKinney (1987) One of the joys of working in a renascent field is that it is actually possible to keep up with the literature. So it is with mixed emotions that we heterochronists (even larval forms like myself) view the recent "veritable explosion of interest in heterochrony" (in Gould's words in this volume). On the positive side, it is ob viously necessary and desirable to extend and expand the inquiry; but one regrets that already we are beginning to talk past, lose track of, and even ignore each other as we carve out individual interests.
Author: Michael Anton Chesney
Publisher:
ISBN:
Category :
Languages : en
Pages : 188
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Author: Lilach Friedlander-Shani
Publisher:
ISBN:
Category :
Languages : en
Pages : 35
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