Molecular and Cellular Methods in Developmental Toxicology PDF Download
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Author: George P. Daston
Publisher: CRC Press
ISBN: 1439810664
Category : Medical
Languages : en
Pages : 336
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Book Description
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
Author: George P. Daston
Publisher: CRC Press
ISBN: 1439810664
Category : Medical
Languages : en
Pages : 336
Get Book Here
Book Description
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
Author: Donald R. Mattison
Publisher: CRC Press
ISBN: 1439861080
Category : Medical
Languages : en
Pages : 340
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Book Description
Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three br
Author: Craig Harris
Publisher: Humana Press
ISBN: 9781493962075
Category : Medical
Languages : en
Pages : 484
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Book Description
This book details methods used to study developmental toxicology. It highlights the evolution of methods from classical teratology approaches to dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Robert C. Smart
Publisher: John Wiley & Sons
ISBN: 1119042410
Category : Science
Languages : en
Pages : 1060
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Book Description
Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition
Author: Stephen Klug
Publisher: Wiley-Blackwell
ISBN: 9780632041879
Category : Science
Languages : en
Pages : 240
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Book Description
Experimental work in animal systems involves investigations of organisms at the molecular and the cellular level. This book provides information on the latest research from the areas of both developmental toxicology and developmental biology. It covers a wide spectrum of the most powerful techniques currently available for studying the basic parameters of in vitro and in vivo development. The detailed theoretical background allows critical assessment and application of these techniques. The authors--all accomplished and world renowned experts in their topic areas--supply their accounts of the current research status in developmental toxicology and biology. This book is intended to catalyze exchange and collaboration between scientists in these disciplines and to provide newcomers with an entry to this research field.
Author: George P. Daston
Publisher: CRC Press
ISBN: 9781439810668
Category : Medical
Languages : en
Pages : 336
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Book Description
This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.
Author: CaroleAKimmel
Publisher: CRC Press
ISBN: 9780781701372
Category : Medical
Languages : en
Pages : 502
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Book Description
The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.
Author: Jesús del Mazo
Publisher: Springer Science & Business Media
ISBN: 1489900896
Category : Medical
Languages : en
Pages : 221
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Book Description
Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.
Author: Deborah K. Hansen
Publisher: CRC Press
ISBN: 9781420054378
Category : Medical
Languages : en
Pages : 0
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Book Description
Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes
