Modular Single-chain Polymer Nanoparticles in Drug Delivery PDF Download
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Author: Anna Pia Pauline Kröger
Publisher:
ISBN: 9789036546232
Category :
Languages : en
Pages : 198
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Book Description
Author: Anna Pia Pauline Kröger
Publisher:
ISBN: 9789036546232
Category :
Languages : en
Pages : 198
Get Book Here
Book Description
Author: José A. Pomposo
Publisher: John Wiley & Sons
ISBN: 3527806393
Category : Technology & Engineering
Languages : en
Pages : 504
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Book Description
This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Author: Naomi Marie Hamelmann
Publisher:
ISBN: 9789036554398
Category :
Languages : en
Pages : 0
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Book Description
Author: Cédric Chauvierre
Publisher: Editions Universitaires Europeennes
ISBN: 9786131535178
Category : Drug carriers (Pharmacy)
Languages : en
Pages : 296
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Book Description
One of the main interest of using polymer nanoparticles as drug carrier systems is to control the delivery of the drug and of their biodistribution. It was clearly demonstrated that surface properties of nanoparticles were the key factor which determined the in vivo fate of such a cerrier. While a neutral (stealth(r)) system of appropriate circulation lifetime as poly(ethylene glycol) chains coated nanoparticles is already of interest, an additional positive function can be feasible by a proper design of the exposed nanoparticle surface by using polysaccharide chains which are involved in tissue addressing. In this thesis, monodisperse biodegradable nanoparticles were developed from an original redox radical polymerization reaction of alkylcyanoacrylates in emulsion and requiring only one step in aqueous media. The nanoparticle surfaces exhibited polysaccharides that maintain their biological properties. The nanoparticles were very stable, and their characteristics can be modulated. This offers a new strategy for the design of modular biomimetic nanoparticles as drug carrier systems with multiple functions, with applications such as blood substitutes.
Author: José A. Pomposo
Publisher: John Wiley & Sons
ISBN: 3527806415
Category : Technology & Engineering
Languages : en
Pages : 420
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Book Description
This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Author: Christine Vauthier
Publisher: Springer
ISBN: 3319414216
Category : Medical
Languages : en
Pages : 649
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Book Description
This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.
Author: Helena S. Azevedo
Publisher: Woodhead Publishing
ISBN: 0081020120
Category : Technology & Engineering
Languages : en
Pages : 614
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Book Description
Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials
Author: Alan Omar Burts
Publisher:
ISBN:
Category :
Languages : en
Pages : 47
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Book Description
Developing a modular synthetic route to a combinatorial library of functional nanoparticles for applications like drug delivery is one of the main interests of our group. To this end, we have envisioned a novel nanoparticle architecture called a brush-arm star polymer (BASP), which has polymer brushes on the periphery shielding the core. Such nanoparticles were synthesized by, first, "graft-through" ring-opening metathesis polymerization (ROMP) of a norbornene-macromonomer to create the brush-arms, and second, cross-linking the arms with a bis-norbornene cross-linker to afford star polymers via the "arm-first" star polymer method. Functionality can be installed into the macromonomer (MM) or crosslinker preand post-polymerization. We took advantage of the highly efficient third-generation Grubbs catalyst to polymerize a polyethylene glycol (PEG) macromonomer (MM) and a bisnorbornene nitrobenzyloxycarbonyl (NBOC) photocleavable cross-linker to cross-link the brush-arms, which led to low-dispersity (Đ /=1.23) core-degradable BASPs. Controlled degradation of these star polymers was achieved by UV irradiation (365 nm). Next, a novel branched norbornene-polystyrene (PS)-polylactide (PLA)-MM was used to create pseudo-alternating copolymers and miktoarm-BASPs. Transmission electron miscroscopy (TEM) of these star polymers revealed nanoparticles with segregated domains. Also, new cross-linkers were explored containing two different bis-norbornene reversible addition-fragmentation chain-transfer (RAFT) agents. A more flexible RAFT initiator crosslinker led to high-dispersity (Đ \=1.52) BASPs, while the more rigid RAFT initiator crosslinker led to low-dispersity (Đ
Author: José L. Arias
Publisher: CRC Press
ISBN: 1466599480
Category : Medical
Languages : en
Pages : 378
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Book Description
Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatfo
Author: Andreas M Nystroem
Publisher: Smithers Rapra
ISBN: 1847357466
Category : Medical
Languages : en
Pages : 108
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Book Description
Polymers are one of the most applicable and clinically relevant materials for constructing nanomedical systems. These systems are expected to have a future in the clinic; nanomedical constructs will have wide implications for how we treat and diagnose society's most complex diseases, such as cancer, inflammation and genetic disorders. This update focuses on describing the fundamentals of controlled polymerisation techniques and methods for constructing advanced polymer architectures to be used in polymer based nanomedicine. This growing field is reviewed, which uses recent advances in polymer chemistry and conjugation techniques to construct advanced nanoparticles. One focus of this update is to give examples of recent developments in drug delivery, ligand targeted therapy and diagnostic imaging techniques. One section is devoted to the latest developments in nanomedicine - theranostic systems - which combine therapeutic delivery with diagnostic imaging capabilities in the same device. Such systems will play a crucial role in developing personalised medicine.
