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Author: 蘇怡帆
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: 蘇怡帆
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Luigi Pasqua
Publisher: Smithers Rapra
ISBN: 1847355099
Category : Medical
Languages : en
Pages : 182
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Book Description
This book provides an insightful understanding of the mesoporous silica structure and its special properties. The details of synthesis and modification strategies are discussed by reviewing the open literature. The discussion concerning the potential of mesoporous silica in modern biomedical applications will be related to a critical analysis in the field of material science. This book will help the reader rapidly develop the necessary tools to follow the design of the different mesoporous silica-based devices presented in the various studies. The structure of the different devices is examined in detail and the relationship between the structure and the expected activity are discussed. It will also assist in the ability to design new therapeutic devices in a field where the applications seem to be without limits.
Author: Yvonne Perrie
Publisher: Pharmaceutical Press
ISBN: 0857110594
Category : Medical
Languages : en
Pages : 257
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Book Description
"Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.
Author:
Publisher: Academic Press
ISBN: 0128155205
Category : Science
Languages : en
Pages : 185
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Book Description
Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series Updated release includes the latest information on Cancer Therapy and Diagnosis
Author: Yu Chen
Publisher: Springer
ISBN: 3662486229
Category : Technology & Engineering
Languages : en
Pages : 100
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Book Description
This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128166304
Category : Medical
Languages : en
Pages : 530
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Book Description
Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies. Highlights the term nanotherapeutics and presents several classifications of nanotherapeutics from different points-of-view Presents the recent progress related to nanotherapeutics in the oral cavity Provides the recent progress in the field of biomedical nanoparticles
Author: Eun Ji Chung
Publisher: Elsevier
ISBN: 0128166630
Category : Technology & Engineering
Languages : en
Pages : 440
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Book Description
Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes Discusses the major techniques for designing nanoparticles for use in biomedicine Explores safety and regulatory aspects for the use of nanoparticles in biomedicine
Author: Wei Chen
Publisher:
ISBN:
Category :
Languages : en
Pages : 263
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Book Description
Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.
Author: Zilu Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 203
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Book Description
This thesis involves synthesis, derivatization and biomedical applications of mesoporous silica nanopartilces (MSNs) and Fe3O4@SiO2 core/shell nanoparticles. Chapter 1 introduces the development of MSNs including the mesopores formation mechanism, synthesis conditions and their capability to act as stimuli responsive drug delivery platforms. In chapter 2, the synthesis optimization of different kinds of particles and their surface derivatization are introduced. Chapter 3 & 4 give specific examples of successful optimization and in vitro and in vivo application of MSNs enabled with pH-sensitive nanovalves and disulfide snap-tops for delivering the antibiotic moxifloxacin. It is shown that a high release capacity is necessary to reach a high efficacy ratio, compared with free drug. Chapter 5 discusses the uptake and release capacities of Fe3O4@SiO2 core/shell nanoparticles when modified with a pH-sensitive nanovalves, and its thermally cargo release behavior when surrounding temperature increases or an oscillating magnetic field is applied. In Chapter 6, successful distribution of Fe3O4@SiO2 core/shell nanoparticles in biofilms and on-command release of cargo inside biofilms are shown. Overall, these chapters demonstrate the ability of modifying both the outer surface and interior of MSNs, and their capability to act as a biocompatible controlled release platform that is more effective than equivalent amount of free drug.
Author: Malay K. Das
Publisher: Springer Nature
ISBN: 9811562555
Category : Science
Languages : en
Pages : 634
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Book Description
This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.
