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Author: Paulo J. Oliveira
Publisher: Springer
ISBN: 3319733443
Category : Medical
Languages : en
Pages : 708
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Book Description
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
Author: Paulo J. Oliveira
Publisher: Springer
ISBN: 3319733443
Category : Medical
Languages : en
Pages : 708
Get Book
Book Description
This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
Author: Giampaolo Morciano
Publisher: Frontiers Media SA
ISBN: 2889669424
Category : Science
Languages : en
Pages : 182
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Book Description
Author: Marcos Roberto de Oliveira
Publisher: Elsevier
ISBN: 0323884636
Category : Science
Languages : en
Pages : 800
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Book Description
Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies that illustrate the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication
Author: Neelesh Kumar Mehra
Publisher: Elsevier
ISBN: 0323852947
Category : Technology & Engineering
Languages : en
Pages : 604
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Book Description
Multifunctional Nanocarriers provides information on the concept, theory and application of multifunctional nanocarriers. The book covers current research, beginning with product strategy, targeted drug delivery, and advanced drug delivery approaches, along with numerous multifunctional nanocarriers and their regulatory considerations for product development. The book covers targeting, receptor mediated targeting, and recent advancements using multifunctional nanocarriers and their regulatory aspects. This is an important reference source for materials scientists and engineers who want to learn more about how multifunctional nanocarriers are applied in a range of biomedical applications. Explains the fundamentals, concepts, theory and application of multifunctional nanocarriers, with advanced content and applications for a range of biomedical applications Covers production and manufacturing processes for multifunctional nanocarriers for biomedical applications Assesses major challenges in applying multifunctional nanocarriers on an industrial scale
Author: Sajal Chakraborti
Publisher: Springer Nature
ISBN: 9811389462
Category : Science
Languages : en
Pages : 686
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Book Description
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Author: Noel Challamel
Publisher: John Wiley & Sons
ISBN: 1119831814
Category : Science
Languages : en
Pages : 306
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Book Description
This book comprised of three separate volumes presents the recent developments and research discoveries in structural and solid mechanics; it is dedicated to Professor Isaac Elishakoff. This third volume is devoted to non-deterministic mechanics. Modern Trends in Structural and Solid Mechanics 3 has broad scope, covering topics such: design optimization under uncertainty, interval field approaches, convex analysis, quantum inspired topology optimization and stochastic dynamics. The book is illustrated by many applications in the field of aerospace engineering, mechanical engineering, civil engineering, biomedical engineering and automotive engineering. This book is intended for graduate students and researchers in the field of theoretical and applied mechanics.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 9780470725191
Category : Science
Languages : en
Pages : 254
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Book Description
With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail. Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.
Author: Shima Abdollahi
Publisher: CRC Press
ISBN: 1000850110
Category : Medical
Languages : en
Pages : 421
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Book Description
There has been a global rise in the incidence of chronic illnesses, which may be partially attributed to the lengthening of the average human lifespan. Functional foods and nutraceuticals have a potential role to play in the development and maintenance of health. They can assist the body in its battle against inflammation and chronic illnesses. Molecular Mechanisms of Action of Functional Foods and Nutraceuticals for Chronic Diseases addresses the effects and mechanism of functional foods in relation to chronic diseases such as obesity, cardiovascular diseases, diabetes, cancer, etc. This volume, like the first volume Applications of Functional Foods and Nutraceuticals for Chronic Diseases, inspires new thought processes and a paradigm shift in research and development. Key Features: Discusses the molecular mechanism of action, the range of toxicities exerted by these food components for functional foods for addressing chronic conditions Enhances scientists and industrial personnel knowledge of functional foods and in the management of chronic diseases Presents research on the role of functional foods/nutraceuticals in preventing and treating chronic diseases through epigenetic modulation Explores various subjects such as epigenetics, immunological, metabolic, technological and neurodenerative aspects affected by functional foods in chronic diseases The world’s leading wellness centers for chronic diseases are using functional foods and nutraceuticals in their practice and discovering their useful applications, and this second of two volume set is another great reference for practitioners, scientists, and clinicians in the management of chronic diseases. Contributors hail from different geographical locations around the world and have many years of research and scholarly experience in functional foods, nutraceuticals, and biology.
Author: Sten Orrenius
Publisher: CRC Press
ISBN: 1439880034
Category : Medical
Languages : en
Pages : 522
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Book Description
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic
Author:
Publisher: Elsevier
ISBN: 0443188874
Category : Science
Languages : en
Pages : 480
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Book Description
Senescence, Senotherapeutics and Mitochondria, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more. Updates on how mitochondria are closely related to the survival of senescent cells using either mitochondria-targeted senolytic or redox modulator senomorphic strategies Differentiates itself from other books with its multidisciplinary perspectives and multidimensional clinical approaches Offers a novel perspective on both the basic and clinical sciences for a wide group of well-established academicians, students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science and nutritional sciences
