Immunobiology and Immunopharmacology of Bacterial Endotoxins PDF Download
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Author: A. Szentivanyi
Publisher: Springer Science & Business Media
ISBN: 1461322537
Category : Medical
Languages : en
Pages : 499
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Book Description
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.
Author: A. Szentivanyi
Publisher: Springer Science & Business Media
ISBN: 1461322537
Category : Medical
Languages : en
Pages : 499
Get Book Here
Book Description
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: J.W. Hadden
Publisher: Springer Science & Business Media
ISBN: 1461303494
Category : Medical
Languages : en
Pages : 448
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Book Description
'A thoroughly enjoyable and very useful work. As the editors say in their preface, 'we have intended these reviews to be the best by the best'-they make this point very convincingly.' -ASM News, from a review of Volume 1 This series continues to present the most current findings in the field of immune manipulation. Here, twelve chapters provide detailed coverage of cancer, microbial, and allergy immunopharmacology as well as autoimmunity and neuroimmunomodulation.
Author: M. Joseph
Publisher: Academic Press
ISBN: 0080534562
Category : Medical
Languages : en
Pages : 267
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Book Description
Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.
Author:
Publisher:
ISBN:
Category : Chemotherapy
Languages : en
Pages : 932
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Book Description
Author: Lucca Crosby & Andrew Elliott
Publisher: Scientific e-Resources
ISBN: 1839472855
Category :
Languages : en
Pages : 348
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Book Description
Immunology and medical zoology presents current advancements and also thorough surveys in immunology. Articles address the extensive variety of points that contain immunology, including atomic and cell enactment components, phylogeny and sub-atomic development, and clinical modalities. Immunology is the investigation of the body's security from outside macromolecules or attacking life forms and the reactions to them. These trespassers incorporate infections, microorganisms, protozoa or significantly bigger parasites. What's more, immune reactions are produced against our own proteins (and different atoms) in autoimmunity and against our own particular distorted cells in tumor insusceptibility. The principal line of protection against outside creatures are hindrance tissues, for example, the skin that stop the passage of living being into our bodies. A moment line of resistance is the particular or versatile immune framework which may take days to react to an essential attack (that is contamination by a life form that has not up to this point been seen). This new book unites new research from around the world managing this critical subject. Immunology, with its premise in microbiology, is a critical segment of the essential sciences educational modules and has solid relationship with fields, for example, sensitivity, immunochemistry, immunopharmacology and transplantation.
Author: Paul G. Hellewell
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 360
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Book Description
About the Series: The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book: This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309100569
Category : Medical
Languages : en
Pages : 102
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Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Author: F.P. Nijkamp
Publisher: Springer Science & Business Media
ISBN: 3034601360
Category : Medical
Languages : en
Pages : 743
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Book Description
This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.
Author: Julius M. Cruse
Publisher: CRC Press
ISBN: 0849379881
Category : Medical
Languages : en
Pages : 816
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Book Description
From the beginning, immunologists have maintained a unique nomenclature that has often mystified and even baffled their colleagues in other fields, causing them to liken immunology to a black box. With more than 1200 illustrations, the Illustrated Dictionary of Immunology, Third Edition provides immunologists and nonimmunologists a single-volume resource for the many terms encountered in contemporary immunological literature. Encyclopedic in scope and including more than 1200 illustrations, the content ranges from photographs of historical figures to molecular structures of recently characterized cytokines, the major histocompatibility complex molecules, immunoglobulins, and molecules of related interest to immunologists. These descriptive illustrations provide a concise and thorough understanding of the subject. To reflect modern advances, the third edition includes entries on immunopharmacology, newly described interleukins, comparative immunology, immunity to infectious diseases, and expanded definitions in all of the immunological subspecialities. Providing unprecedented breadth and detail, this readily accessible book is not only a pictorial reference but also a primary resource.
