Methods of Assessing the Reinforcing Properties of Abused Drugs PDF Download
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Author: Michael A. Bozarth
Publisher: Springer Science & Business Media
ISBN: 1461248124
Category : Medical
Languages : en
Pages : 658
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Book Description
Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.
Author: Michael A. Bozarth
Publisher: Springer Science & Business Media
ISBN: 1461248124
Category : Medical
Languages : en
Pages : 658
Get Book
Book Description
Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited collection offers a lasting framework for interpreting the results of current experimental findings.
Author: Michael A. Bozarth
Publisher:
ISBN: 9783540966258
Category : Drug abuse
Languages : en
Pages : 658
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Book Description
Author: Marian W. Fischman
Publisher:
ISBN:
Category : Drug abuse
Languages : en
Pages : 420
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Book Description
Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Author: Carrie Markgraf
Publisher: Academic Press
ISBN: 0124202160
Category : Medical
Languages : en
Pages : 321
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Book Description
Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Author: Martin W. Adler
Publisher: Wiley
ISBN: 9780471567431
Category : Medical
Languages : en
Pages : 320
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Book Description
This work describes how critical biological information on today's abused drugs is obtained in both laboratory and clinical settings. Recent methodological advances, both great and small, are presented in a concise manner by experienced researchers and scholars. The text covers wholesale innovations in methodology, in addition to simple modifications of existing methods that often yield great advances, and the strengths and weaknesses of all methods are assessed. The survey is comprehensive and uncovers key characteristics of abused drugs at the receptor level, on animal behavior, and in humans.
Author: Barry D. Waterhouse
Publisher: CRC Press
ISBN: 1420038680
Category : Medical
Languages : en
Pages : 298
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Book Description
The field of drug addiction and substance abuse, which was initially confined to behavioral studies, has broadened dramatically. It now includes a vast array of cellular and molecular approaches as well as sophisticated electrophysiological and neurochemical methodologies that bridge the gap between cellular/molecular events and behavior. In many c
Author: MD, FFFLM, Steven B. Karch
Publisher: CRC Press
ISBN: 1420054600
Category : Law
Languages : en
Pages : 208
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Book Description
Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pharmacokinetics and Pharmacodynamics of Abused Drugs is a concise and focused volume devoted to the metabolism and measurable effects of drugs on the human body. Beginning with basic concepts and models
Author: David M. Warburton
Publisher: CRC Press
ISBN: 1000947238
Category : Medical
Languages : en
Pages : 404
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Book Description
In the past, the prototypes for characterizing drug use were heroin and cocaine, so that research has focused on possible commonalities between any substance and these drugs. Addiction controversies explores the problems of the commonalities approach by looking at dissimilarities as well. The first chapters of Addiction Controversies trace the development of modern medical attitudes to drug use and the current controversy over its decriminalization. The second set of chapters examines the extent to which drugs have common biological and sociological mechanisms of action and contrasts these explanations. The final chapters consider the extent to which the desires for different substances are the same and the biological and social explanations of relapse. Clinicians, researchers and students in all areas of substance use will be stimulated by these challenges to current thinking and will enjoy the comparative approach that is taken by the contributors to Addiction Controversies.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309055334
Category : Medical
Languages : en
Pages : 330
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Book Description
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Author: Thomas Steckler
Publisher: Elsevier
ISBN: 0080553311
Category : Science
Languages : en
Pages : 485
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Book Description
The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.
