Metal Complexes of Phosphinite Ligands as Catalysts for Asymmetric Hydrogenation Reactions PDF Download
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Author: Angela T. Slade
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 408
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Book Description
The objective of this thesis are two-fold. First to ascertain how phosphinite compounds behave when reacted with transition metal substrates. The second objective is to establish whether the resulting complexes were asymmetric catalysts for conversion of prochiral substrates to chiral products in high ee.
Author: Angela T. Slade
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 408
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Book Description
The objective of this thesis are two-fold. First to ascertain how phosphinite compounds behave when reacted with transition metal substrates. The second objective is to establish whether the resulting complexes were asymmetric catalysts for conversion of prochiral substrates to chiral products in high ee.
Author: Paul C. J. Kamer
Publisher: John Wiley & Sons
ISBN: 1118299701
Category : Technology & Engineering
Languages : en
Pages : 673
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Book Description
Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.
Author: Armin Börner
Publisher:
ISBN:
Category : Asymmetric synthesis
Languages : en
Pages : 640
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Book Description
Author: Montserrat Diéguez
Publisher: CRC Press
ISBN: 1000379000
Category : Science
Languages : en
Pages : 298
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Book Description
Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance. Key Features: The book presents historical content from the time of discovery for each family of ligands. Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
Author: David Morales-Morales
Publisher: Elsevier
ISBN: 0128129328
Category : Science
Languages : en
Pages : 756
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Book Description
Pincer Compounds: Chemistry and Applications offers valuable state-of-the-art coverage highlighting highly active areas of research—from mechanistic work to synthesis and characterization. The book focuses on small molecule activation chemistry (particularly H2 and hydrogenation), earth abundant metals (such as Fe), actinides, carbene-pincers, chiral catalysis, and alternative solvent usage. The book covers the current state of the field, featuring chapters from renowned contributors, covering four continents and ranging from still-active pioneers to new names emerging as creative strong contributors to this fascinating and promising area. Over a decade since the publication of Morales-Morales and Jensen’s The Chemistry of Pincer Compounds (Elsevier 2007), research in this unique area has flourished, finding a plethora of applications in almost every single branch of chemistry—from their traditional application as very robust and active catalysts all the way to potential biological and pharmaceutical applications. Describes the chemistry and applications of this important class of organometallic and coordination compounds Includes contributions from global leaders in the field, featuring pioneers in the area as well as emerging experts conducting exciting research on pincer complexes Highlights areas of promising and active research, including small molecule activation, earth abundant metals, and actinide chemistry
Author: David Harrison Woodmansee
Publisher: Cuvillier Verlag
ISBN: 3736934858
Category : Science
Languages : en
Pages : 214
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Book Description
The current trend in developing asymmetric catalysts is towards creating specialized molecules with tailored functions for increased selectivity in classes of substrates rather than general catalysts capable of broad application. In addition, the capacity to generate groups of catalysts with incremental changes to overall structure allows for a more detailed analysis of contributions to the structure selectivity relationships for a variety of substrates. This information can then be used to identify ideal catalysts or improve selectivity and activity of for a particular system. Asymmetric hydrogenation of substituted alkenes with chiral iridium N,P complexes that were developed from the achiral Crabtree Complex have proven to be extraordinary selective and active catalysts. Screening a series of trisubstituted alkenes on 1st and 2nd generation catalysts indicated a strong enantioselectivity dependence on the phosphorus and pyridine substituents. In particular, the substituents in the ortho position of the pyridine ring were found to have significant control over the catalyst. The synthesis of the 3rd generation of chiral pyridyl phosphinite catalysts takes advantage of a flexible late phase incorporation of the functional groups which govern the selectivity of the asymmetric hydrogenation to span a range of steric and electronic properties. The screening of these catalysts in the asymmetric hydrogenation of several classes of trisubstituted alkenes provided clear insight to the factors controlling enantioselectivity which were proven to vary greatly with the nature of the substrate and catalyst. Several catalysts with exceptional selectivity were identified for multiple examples of trisubstituted alkenes which had proven difficult with previous system.
Author:
Publisher: Academic Press
ISBN: 0128245700
Category : Science
Languages : en
Pages : 438
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Book Description
Metal-Catalyzed Asymmetric Hydrogenation, Volume 68 in the Advances in Catalysis series, fills the gap between journal papers and textbooks across diverse areas of catalysis research. For more than 60 years, this series has recorded and presented the latest progress in the field of catalysis, giving the scientific community comprehensive and authoritative reviews. Chapters in this new release include Asymmetric hydrogenation of functionalized olefins, Asymmetric hydrogenation of unfunctionalized olefins or with poorly coordinative groups, Asymmetric hydrogenation of imines, Asymmetric hydrogenation of ketones, Asymmetric hydrogenation in industry, and Computational insights into metal-catalyzed asymmetric hydrogenation. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry, with this release focusing on solid acids, surface acidity and heterogeneous acid catalysis. Contains authoritative reviews written by experts in the field Explores topics that reflect progress in the field, such as catalyst synthesis, catalyst characterization, catalytic chemistry, reaction engineering, computational chemistry and physics Provides insightful and critical articles that are fully edited to suit various backgrounds
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 392
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Book Description
Author: Li-Xin Dai
Publisher: John Wiley & Sons
ISBN: 3527322809
Category : Science
Languages : en
Pages : 433
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Book Description
This book meets the long-felt need for a reference on ferrocenes with the focus on catalysis. It provides a thorough overview of the synthesis and characterization of different types of chiral ferrocene ligands, their application to various catalytic asymmetric reactions, and versatile chiral materials as well as drug intermediates synthesized from them. Written by the "who's who" of ferrocene catalysis, this is a guide to the design of new ferrocene ligands and synthesis of chiral synthetic intermediates, and will thus be useful for organic, catalytic and synthetic chemists working in academia, industrial research or process development.
Author: Arnald Grabulosa
Publisher: Royal Society of Chemistry
ISBN: 1849731233
Category : Science
Languages : en
Pages : 521
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Book Description
P-stereogenic ligands were among the first to be used in asymmetric catalysis but synthetic difficulties and prejudices have hampered their development. However, continuous screening for new chiral ligands means that they can no longer be ignored and this rigorous reference source reflects their renaissance.The book is filled with many examples from recent primary literature. The synthetic chemist will easily be able to follow the preparation methods which are accompanied by a description of the challenges and limitations. Those working in homogenous catalysis, and wanting to increase their repertoire of ligands, will be able to establish which have already been used in each reaction and their performance.This book provides comprehensive coverage of the application of P-stereogenic ligands in homogeneous catalysis. It begins with a brief chapter on generalities of P-stereogenic compounds: history, configurational stability, and interconversions among them.The book then goes on to describe the main preparative methods, from resolution of racemates to enantioselective catalysis, before focusing on the catalytic applications of P-stereogenic ligands. Chapter 7 describes the use of the ligands in catalytic hydrogenation and related reactions whereas chapter 8 deals with other reactions, mainly C-C bond forming reactions. The aim of these two final chapters is to give an outline of the usefulness of the ligands in homogeneous catalysis.
