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Author: Ute Roessner
Publisher: Humana
ISBN: 9781493963010
Category : Medical
Languages : en
Pages : 0
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Book Description
Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.
Author: Ute Roessner
Publisher: Humana
ISBN: 9781493963010
Category : Medical
Languages : en
Pages : 0
Get Book Here
Book Description
Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.
Author: Kazuki Saito
Publisher: Springer Science & Business Media
ISBN: 3540297820
Category : Science
Languages : en
Pages : 351
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Book Description
Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.
Author: Norbert W. Lutz
Publisher: Cambridge University Press
ISBN: 0521765900
Category : Medical
Languages : en
Pages : 641
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Book Description
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
Author: J. Mulzer
Publisher: Springer Science & Business Media
ISBN: 3662040425
Category : Medical
Languages : en
Pages : 363
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Book Description
Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Author: Md Tofazzal Islam
Publisher: Springer Nature
ISBN: 3030151751
Category : Science
Languages : en
Pages : 334
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Book Description
The Gram-positive and spore-forming Bacilli are the most dominant group of bacteria that exist in various ecological niches on the earth. They represent one of the most important unmapped pools of biodiversity with immense potential of applications in agriculture, environment, and industry. As these bacteria are highly tolerant to stressful environment and enhance plant tolerance to harsh environment such as salinity, drought, and heavy metal toxicity, plant-associated Bacilli have high potential for promoting sustainable crop production. Many species of Bacilli are being commercially used as phytostimulator and biofertilizer. Some of them are applied as biopesticide for protecting crop plants from phytopathogens and insect pests. The Bacillus-based products are becoming popular in ecologically sound and climate resilient agricultural production system. In fact, Bacillus and allied species based formulations are already dominating the biopesticides market, although, to compete with other formulations and chemical alternatives, the biology of Bacillus had to be understood from perspective of such applications. Our understanding of the biology and molecular-basis of the beneficial effects of plant-associated Bacilli has greatly been progressed in recent years through genomics, metagenomics, post-genomics and metabolomics studies. The volume two of the series Bacilli and Agrobiotechnology comprehensively reviews and updates current knowledge of Bacilli as phytostimulant and biological control of plant pests. Better understanding the biology, ecology and mechanism of action of the beneficial strains of Bacilli will play a role in the development of products to support green biotechnology in agriculture and industries.
Author: Robert Winkler
Publisher: Royal Society of Chemistry
ISBN: 1788017218
Category : Science
Languages : en
Pages : 460
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Book Description
Metabolomics and proteomics allow deep insights into the chemistry and physiology of biological systems. This book expounds open-source programs, platforms and programming tools for analysing metabolomics and proteomics mass spectrometry data. In contrast to commercial software, open-source software is created by the academic community, which facilitates the direct interaction between users and developers and accelerates the implementation of new concepts and ideas. The first section of the book covers the basics of mass spectrometry, experimental strategies, data operations, the open-source philosophy, metabolomics, proteomics and statistics/ data mining. In the second section, active programmers and users describe available software packages. Included tutorials, datasets and code examples can be used for training and for building custom workflows. Finally, every reader is invited to participate in the open science movement.
Author: Vladimir Havlicek
Publisher: John Wiley & Sons
ISBN: 1118466616
Category : Science
Languages : en
Pages : 634
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Book Description
This book highlights analytical chemistry instrumentation and practices applied to the analysis of natural products and their complex mixtures, describing techniques for isolating and characterizing natural products. • Applies analytical techniques to natural products research – an area of critical importance to drug discovery • Offers a one-stop shop for most analytical methods: x-ray diffraction, NMR analysis, mass spectrometry, and chemical genetics • Includes coverage of natural products basics and highlights antibacterial research, particularly important as efforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail for both current practitioners and beginning researchers
Author: Hector C Keun
Publisher: Royal Society of Chemistry
ISBN: 184973643X
Category : Medical
Languages : en
Pages : 384
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Book Description
This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.
Author: Loïc Charpy
Publisher: Musee Oceanographique
ISBN:
Category : Science
Languages : en
Pages : 644
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Book Description
Author: Valdir Cechinel Filho
Publisher: Springer
ISBN: 3030005453
Category : Science
Languages : en
Pages : 531
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Book Description
This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.
