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Author: Jing Wang
Publisher: Bentham Science Publishers
ISBN: 1681083159
Category : Science
Languages : en
Pages : 408
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Book Description
This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine.
Author: Jing Wang
Publisher: Bentham Science Publishers
ISBN: 1681083159
Category : Science
Languages : en
Pages : 408
Get Book Here
Book Description
This monograph provides a current and in-depth review of scholarly information about mesenchymal stem cells and their application in the craniofacial region of the human body. Chapters in this volume cover biological and conceptual information about mesenchymal stem cells, induced pluripotent stem cells, craniofacial regeneration, new methods of scaffold fabrication, tooth regeneration and three-dimensional printing in dentistry. The book is suitable for clinicians and cell biologists aiming to gain a better understanding of the promising field of craniofacial regenerative medicine.
Author: George T.J. Huang
Publisher: John Wiley & Sons
ISBN: 1118498119
Category : Science
Languages : en
Pages : 578
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Book Description
Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.
Author: Peter Giannoudis
Publisher: Academic Press
ISBN: 0124081312
Category : Science
Languages : en
Pages : 73
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Book Description
Mesenchymal Stem Cells and Skeletal Regeneration covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. - Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialists - Provides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC research - Assists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context
Author: Ajaykumar Vishwakarma
Publisher: Academic Press
ISBN: 0123977789
Category : Technology & Engineering
Languages : en
Pages : 933
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Book Description
Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. - Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization - Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology - Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine - Print book is available and black and white, and the ebook is in full color
Author: Vincenzo Guarino
Publisher: CRC Press
ISBN: 042975082X
Category : Medical
Languages : en
Pages : 519
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Book Description
Oral tissue engineering involves the study of current approaches for in vitro regeneration of soft and hard tissues located into the oral cavity. In this context, recent approaches involves the use of innovative biomaterials to replace the lost or damaged human oral tissues. Recent discoveries in materials science and nanotechnology are drastically changing the traditional approach to dentistry by the design of innovative devices able more efficiently supporting the natural regeneration process. The objective of this book is to highlight current progress in tissue engineering for various dental hard/soft tissues including enamel, dentin, pulp, alveolar bone, periodontium, gum and oral mucosa, by emphasizing the role of materials and their specific applications.
Author: Jin Ke
Publisher:
ISBN: 9781361247976
Category :
Languages : en
Pages :
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Book Description
This dissertation, "Transgenic Stem Cells for Craniofacial Bone Reconstruction" by Jin, Ke, 柯金, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Bone loss from the cranio-maxillofacial region is a major clinical problem affecting patients worldwide. Conventional treatment strategy includes the use of autogenous or allogeneic bone, biomaterials, and osteogenic growth factors. However, there has been no effective therapy for most cases so far. Stem cell-based gene therapy is the latest research method with possible applications in humans. The present study aims to (1) characterize rabbit mesenchymal stem cells (MSCs) relating to growth pattern, surface antigens, and the potential for multi-differentiation; (2) determine the transduction efficiency and duration of recombinant adeno-associated virus2 carrying enhanced green fluorescent protein (rAAV2EGFP) reporter gene in rabbit MSCs and study the effects of rAAV2EGFP transduction on stem cells' phenotype and capacity of multi-differentiation; (3) evaluate the differentiation characteristics of rabbit MSCs following recombinant adeno-associated virus 2 carrying bone morphogenetic protein 2 gene (rAAV2BMP2) transduction; (4) investigate whether MSCs transduced by rAAV2BMP2 could successfully induce bone regeneration in rabbit critical-size cranial defects. MSCs were isolated from bone marrows of rabbit tibias and cultured. Cell counting and colony-forming assays demonstrated that growth rates of MSCs dropped substantially with increasing passages. Flow cytometry on MSCs at passage 1 showed that cells expressed high level of CD49a and low level of CD44 as well as stage-specific embryonic antigen 4 (SSEA4). Multi-differentiation and reverse transcriptase-polymerase chain reaction (RTPCR) tests demonstrated that rabbit MSCs were capable to differentiate into osteocytes, chondrocytes and adipocytes. Immunofluorescence microscopy showed that rabbit MSCs produced a series of hematopoietic growth factors, including stem cell factor (SCF), vascular endothelial growth factor-A (VEGFA) and granulocyte macrophage colony-stimulating factor (GMCSF). Subsequently, rabbit MSCs were transduced with rAAV2EGFP in vitro. By comparing the transduction efficiency with different doses of rAAV2EGFP particles, multiplicity of infection (MOI) of 1 x 10 4 was identified as an optimal parameter for the transduction of rAAV2 in rabbit MSCs. Fluorescent microscopy demonstrated long-term expression of EGFP in rabbit MSCs after transduction both in vitro and in vivo. In addition, cell proliferation assay, adipogenic induction test and flow cytometry showed that rAAV2EGFP transduced MSCs exhibited a similar pattern with non-transduced cells on the cell growth, capacity of adipogenic differentiation and expression of surface antigens, indicating that rabbit MSCs maintain their stem cell properties after rAAV2EGFP transduction. DOI: 10.5353/th_b4436297 Subjects: Facial bones - Surgery Bone regeneration Stem cells - Therapeutic use Transgenic animals - Research
Author: Yunfeng Lin
Publisher: Humana Press
ISBN: 3319516175
Category : Science
Languages : en
Pages : 98
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Book Description
This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.
Author: Ahmed El-Hashash
Publisher: Academic Press
ISBN: 0128197137
Category : Science
Languages : en
Pages : 228
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Book Description
Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world
Author: Doug Hickman
Publisher: American Medical Publishers
ISBN:
Category : Medical
Languages : en
Pages : 0
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Book Description
The craniofacial complex encases the brain along with other organs for vital functions of the body, such as taste, mastication, vision, smell, breathing, hearing and balance. The fusion, patterning, outgrowth and shaping tissues with heterogeneous developmental origins are necessary for craniofacial development. Mesenchymal stem cells (MSCs) have the potential to be used in the repair of craniofacial tissues, because these cells are adept at changing into cartilage, tendon, bone, muscle and fat. Craniofacial bone reconstruction is significant when it comes to craniofacial repairs, because it provides support to nearby soft tissues. Furthermore, it provides anchorage for dental structures which guide facial appearance, as well as structural stability. The regeneration of craniofacial tissue and organs is possible using bio-ink along with various stem cells and biomaterials in 3D bio printers. This book unravels the recent studies on craniofacial tissues and organs. It aims to shed light on the processes of repair and regeneration of these tissues and organs. This book will help new researchers by foregrounding their knowledge in this area of study.
Author: Fikrettin Şahin
Publisher: Springer
ISBN: 3319289470
Category : Science
Languages : en
Pages : 322
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Book Description
This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.
