Author: Chris J Jones
Publisher: Royal Society of Chemistry
ISBN: 1847557759
Category : Science
Languages : en
Pages : 371
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Book Description
Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.
Author: Chris J. Jones
Publisher: Royal Society of Chemistry
ISBN: 0854045961
Category : Medical
Languages : en
Pages : 372
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Book Description
This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity. This product is not available separately, it is only sold as part of a set. There are 750 products in the set and these are all sold as one entity.
Author: Tim Storr
Publisher: John Wiley & Sons
ISBN: 1118697898
Category : Science
Languages : en
Pages : 650
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Book Description
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Author: Shahid Ul Islam
Publisher: John Wiley & Sons
ISBN: 1119640423
Category : Science
Languages : en
Pages : 432
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Book Description
This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.
Author: Jonathan L. Sessler
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 480
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Book Description
This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.
Author: Nicholas Farrell
Publisher: Royal Society of Chemistry
ISBN: 9780854044443
Category : Medical
Languages : en
Pages : 180
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Book Description
This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will be an invaluable asset for many in the discipline.
Author: Astrid Sigel
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311047073X
Category : Science
Languages : en
Pages : 588
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Book Description
Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Author: Geoffrey A. Lawrance
Publisher: John Wiley & Sons
ISBN: 1118681401
Category : Science
Languages : en
Pages : 307
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Book Description
At the heart of coordination chemistry lies the coordinate bond, in its simplest sense arising from donation of a pair of electrons from a donor atom to an empty orbital on a central metalloid or metal. Metals overwhelmingly exist as their cations, but these are rarely met ‘naked’ – they are clothed in an array of other atoms, molecules or ions that involve coordinate covalent bonds (hence the name coordination compounds). These metal ion complexes are ubiquitous in nature, and are central to an array of natural and synthetic reactions. Written in a highly readable, descriptive and accessible style Introduction to Coordination Chemistry describes properties of coordination compounds such as colour, magnetism and reactivity as well as the logic in their assembly and nomenclature. It is illustrated with many examples of the importance of coordination chemistry in real life, and includes extensive references and a bibliography. Introduction to Coordination Chemistry is a comprehensive and insightful discussion of one of the primary fields of study in Inorganic Chemistry for both undergraduate and non-specialist readers.
Author: Enzo Alessio
Publisher: John Wiley & Sons
ISBN: 352763312X
Category : Science
Languages : en
Pages : 625
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Book Description
This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic.
Author: J. A. McCleverty
Publisher: Newnes
ISBN: 0080913164
Category : Science
Languages : en
Pages : 11845
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Book Description
Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.
