Medical Aspects of Proteases and Protease Inhibitors PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Medical Aspects of Proteases and Protease Inhibitors PDF full book. Access full book title Medical Aspects of Proteases and Protease Inhibitors by Nobuhiko Katunuma. Download full books in PDF and EPUB format.
Author: Nobuhiko Katunuma
Publisher:
ISBN: 9784274901300
Category : Endopeptidases
Languages : en
Pages : 205
Get Book Here
Book Description
Author: Nobuhiko Katunuma
Publisher:
ISBN: 9784274901300
Category : Endopeptidases
Languages : en
Pages : 205
Get Book Here
Book Description
Author: Nobuhiko Katunuma
Publisher: IOS Press
ISBN: 9789051992922
Category : Enzyme inhibitors
Languages : en
Pages : 224
Get Book Here
Book Description
The work presents articles on proteases and their inhibitors as mediators of biological functions. Topics addressed: cathepsin B and L; MHC and peptide interaction; procathepsin L; cysteine proteinases; selective neuronal cell death; HIV and influenza virus; tumor invasion; gingivitis; bacterial infection. Readers: professionals in the area of molecular medicine, biochemists, molecular biologists, clinical pharmacologists, pharmaceutical companies.
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811061416
Category : Medical
Languages : en
Pages : 668
Get Book Here
Book Description
This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author: Uwe Lendeckel
Publisher: Springer Science & Business Media
ISBN: 9048123488
Category : Medical
Languages : en
Pages : 139
Get Book Here
Book Description
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Author: Enrico Di Cera
Publisher: Academic Press
ISBN: 0123855047
Category : Medical
Languages : en
Pages : 336
Get Book Here
Book Description
Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Author: Sajal Chakraborti
Publisher: Springer
ISBN: 9811031622
Category : Medical
Languages : en
Pages : 516
Get Book Here
Book Description
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author: Yehudith Birk
Publisher: Springer Science & Business Media
ISBN: 9783540001188
Category : Health & Fitness
Languages : en
Pages : 192
Get Book Here
Book Description
Plant protease inhibitors are diverse in number & specificity towards various proteolytic enzymes.
Author:
Publisher: ScholarlyEditions
ISBN: 1464936544
Category : Medical
Languages : en
Pages : 91
Get Book Here
Book Description
Protease Inhibitors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protease Inhibitors in a concise format. The editors have built Protease Inhibitors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protease Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protease Inhibitors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: J-M. Foidart
Publisher: Springer Science & Business Media
ISBN: 1402009232
Category : Medical
Languages : en
Pages : 259
Get Book Here
Book Description
In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.
Author: Walter H. Horl
Publisher: Springer Science & Business Media
ISBN: 1461593557
Category : Science
Languages : en
Pages : 576
Get Book Here
Book Description
We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October 17-20, 1982. The topics discussed included those dealing with the physi ology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-kinin system, complement and the coagulation system, the function of proteases in the kidney and the intestinal tract as well as the role of proteases in lung diseases, pancreatitis, arthritis and hypercatabolic states (multiple trauma, septicemia, acute renal failure). The papers presented answered many questions, but raised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortunately impossible in this volume to in clude the extended, lively and extremely stimulating discussions which were enjoyed by the participants during the conference. The meeting has provided a unique framework for close inter action between scientists from various disciplines, including bio chemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pulmonology and nephrology. We would like to express our thanks and appreciation for all those who have stimulated, encouraged and supported us to hold this symposium in WUrzburg. This endeavor could not have been possible without the generous financial support of the Paul-Martini Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg).
