Mechanical Engineering of the Cytoskeleton in Developmental Biology PDF Download
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Author:
Publisher: Academic Press
ISBN: 0080856888
Category : Science
Languages : en
Pages : 451
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Book Description
Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.
Author:
Publisher: Academic Press
ISBN: 0080856888
Category : Science
Languages : en
Pages : 451
Get Book Here
Book Description
Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.
Author:
Publisher: Academic Press
ISBN: 9780123645531
Category : Science
Languages : en
Pages : 431
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Book Description
Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Mohammad R. K. Mofrad
Publisher: Cambridge University Press
ISBN: 1139458108
Category : Science
Languages : en
Pages : 231
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Book Description
This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.
Author: Jürgen Bereiter-Hahn
Publisher: Springer Science & Business Media
ISBN: 3642728634
Category : Science
Languages : en
Pages : 304
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Book Description
Genetic information determines the composition of molecules comprising cytoskeletal elements, membranes and receptors. The supramolecular arrangement of these components represents a self-assembly process controlled by physicochemical and mechanical interactions. This general hypothesis demarcates the aim of studying cellular mechanics. Description and evaluation of mechanical properties of cells and their organelles, as well as of the forces exerted by them, is the scope of this book on Cytomechanics. Emphasis is laid on the role of mechanical properties in the generation of shape and cytoplasmic motion, and on the basic principles and components determining mechanical properties.
Author: David H. Boal
Publisher: Cambridge University Press
ISBN: 0521113768
Category : Science
Languages : en
Pages : 623
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Book Description
New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.
Author: Jonathon Howard
Publisher: Sinauer
ISBN: 9780878933334
Category : Science
Languages : en
Pages : 0
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Book Description
Mechanics of Motor Proteins and the Cytoskeleton provides a physical foundation for molecular mechanics. Part I explains how small particles like proteins respond to mechanical, thermal, and chemical forces, Part II focuses on cytoskeletal filaments, and Part III focuses on motor proteins. The treatments are unified in the respect that they are organized around principles rather than proteins: chapters are centred on topics such as structure, chemistry, and mechanics, and different filaments or motors are discussed together.
Author:
Publisher: Elsevier
ISBN: 0128240326
Category : Science
Languages : en
Pages : 120
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Book Description
Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Gut developmental mechanics, Long bone developmental mechanics, Cranial plate fusion developmental mechanics, Mechanobiology and vasculogenesis, Morphogenesis and mechanics of the developing inner ear, Morphogenesis and mechanics of body wall closure in mammals, Salivary bud developmental mechanics, Lateral plate mesoderm developmental mechanics, Biomechanics of human embryo implantation, gastrulation, and organ formation, Mechanics of lung development across species, Mechanics early development in vertebrates.
Author: Kevin Moses
Publisher: Springer Science & Business Media
ISBN: 9783540425908
Category : Medical
Languages : en
Pages : 296
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Book Description
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Author: Roland Kaunas
Publisher: CRC Press
ISBN: 1466553812
Category : Medical
Languages : en
Pages : 380
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Book Description
Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell–cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.
