Matching the Neural Adaptation in the Rat Ventral Cochlear Nucleus Produced by Artificial (electric) and Acoustic Stimulation of the Cochlea PDF Download
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Languages : en
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Book Description
To investigate neural adaptive properties, near-field evoked potentials were recorded from a chronically implanted electrode in the ventral cochlear nucleus in awake Long-Evans rats exposed to acoustic stimuli or receiving intracochlear electric stimulation. Stimuli were 250-ms trains of repetitive acoustic clicks (10, 30 and 50 dB SPL) or biphasic electric pulses (30, 50 and 70 μA) with intratrain pulse rates ranging from 100 to 1000 pulses per second (pps). The amplitude of the first negative (N1) to positive (P1) component of the average evoked potentials was measured for each consecutive individual pulse in the train. While a progressive exponential decrease in N1-P1 amplitude was observed as a function of the position of the pulse within the train for both types of stimulation, the decrement of electric responses (adaptive pattern) was substantially less prominent than that observed for acoustic stimuli. Based on this difference, the present work was extended by modifying electric stimuli in order to try to restore normal adaptation phenomena. The results suggest the feasibility of mimicking acoustic adaptation by stimulation with exponentially decreasing electric pulse trains, which may be clinically applicable in the auditory implant field.
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Languages : en
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Book Description
To investigate neural adaptive properties, near-field evoked potentials were recorded from a chronically implanted electrode in the ventral cochlear nucleus in awake Long-Evans rats exposed to acoustic stimuli or receiving intracochlear electric stimulation. Stimuli were 250-ms trains of repetitive acoustic clicks (10, 30 and 50 dB SPL) or biphasic electric pulses (30, 50 and 70 μA) with intratrain pulse rates ranging from 100 to 1000 pulses per second (pps). The amplitude of the first negative (N1) to positive (P1) component of the average evoked potentials was measured for each consecutive individual pulse in the train. While a progressive exponential decrease in N1-P1 amplitude was observed as a function of the position of the pulse within the train for both types of stimulation, the decrement of electric responses (adaptive pattern) was substantially less prominent than that observed for acoustic stimuli. Based on this difference, the present work was extended by modifying electric stimuli in order to try to restore normal adaptation phenomena. The results suggest the feasibility of mimicking acoustic adaptation by stimulation with exponentially decreasing electric pulse trains, which may be clinically applicable in the auditory implant field.
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Category : Medicine
Languages : en
Pages : 2160
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Book Description
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
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Category : Audiology
Languages : en
Pages : 360
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Book Description
Author: Kaspar Ueli Meyer
Publisher:
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Category :
Languages : en
Pages : 270
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Book Description
Author: Kaspar Ueli Meyer
Publisher:
ISBN:
Category :
Languages : en
Pages : 270
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Book Description
Author: Terence W. Picton
Publisher: Plural Publishing
ISBN: 1597566225
Category : Medical
Languages : en
Pages : 649
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Book Description
This book reviews how we can record the human brain's response to sounds, and how we can use these recordings to assess hearing. These recordings are used in many different clinical situations--the identification of hearing impairment in newborn infants, the detection of tumors on the auditory nerve, the diagnosis of multiple sclerosis. As well they are used to investigate how the brain is able to hear--how we can attend to particular conversations at a cocktail party and ignore others, how we learn to understand the language we are exposed to, why we have difficulty hearing when we grow old. This book is written by a single author with wide experience in all aspects of these recordings. The content is complete in terms of the essentials. The style is clear; equations are absent and figures are multiple. The intent of the book is to make learning enjoyable and meaningful. Allusions are made to fields beyond the ear, and the clinical importance of the phenomena is always considered.
Author: Firas H. Kobeissy
Publisher: CRC Press
ISBN: 1466565993
Category : Medical
Languages : en
Pages : 718
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Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: Mihail C. Roco
Publisher: Springer Science & Business Media
ISBN: 9401703590
Category : Technology & Engineering
Languages : en
Pages : 477
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Book Description
M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
Author: G. Buzsáki
Publisher: Oxford University Press
ISBN: 0199828237
Category : Medical
Languages : en
Pages : 465
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Book Description
Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the coevolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brain's fundamental organizer of neuronal information. The small-world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive "metastable" state and provide energy-efficient synchronizing mechanisms via weak links. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.
Author: Bin He
Publisher: Springer Science & Business Media
ISBN: 1461452279
Category : Technology & Engineering
Languages : en
Pages : 801
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Book Description
Neural Engineering, 2nd Edition, contains reviews and discussions of contemporary and relevant topics by leading investigators in the field. It is intended to serve as a textbook at the graduate and advanced undergraduate level in a bioengineering curriculum. This principles and applications approach to neural engineering is essential reading for all academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals wishing to take advantage of the latest and greatest in this emerging field.
