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Author: Jon M. Oatley
Publisher: Springer
ISBN: 1493975056
Category : Science
Languages : en
Pages : 385
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Book Description
This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals. Considering that covering the entire gamut of all things spermatogonia is a difficult task, specific topics were selected to provide foundational information that will be useful for seasoned researchers in the field of germ cell biology as well as investigators entering the area. Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals.
Author: Jon M. Oatley
Publisher: Springer
ISBN: 1493975056
Category : Science
Languages : en
Pages : 385
Get Book Here
Book Description
This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals. Considering that covering the entire gamut of all things spermatogonia is a difficult task, specific topics were selected to provide foundational information that will be useful for seasoned researchers in the field of germ cell biology as well as investigators entering the area. Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Sardul S. Guraya
Publisher: Springer Science & Business Media
ISBN: 3642716385
Category : Science
Languages : en
Pages : 441
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Book Description
Author: Oleksandr Kirsanov
Publisher:
ISBN:
Category :
Languages : en
Pages : 92
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Book Description
Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs divide, their progeny must either remain an SSC to maintain the stem cell pool (self-renewal) or become an undifferentiated progenitor spermatogonium that proliferates prior to differentiating in response to retinoic acid (RA) and entering meiosis. Our laboratory is focused on understanding the mechanisms that regulate these fate decisions as well as defining the changes that occur downstream of RA that prepare spermatogonia for entry into meiosis. Currently, researchers have been unable to readily isolate pure populations of spermatogonia in the developing or adult testis. To address this, I have examined multiple transgenic mouse models to identify those with germ cell-specific expression of fluorescent reporter genes that will enable us to isolate spermatogonia using fluorescence-activated cell sorting (FACS). The results in this thesis describe these efforts, and document the identification of an excellent mouse model for future studies in our laboratory to understand the mechanisms underlying spermatogonial development. This work was supported by a grant from the NIH/NICHD (HD090083) to C.B.G.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264243178
Category :
Languages : en
Pages : 13
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Book Description
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells
Author: Bernard Robaire
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 536
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Book Description
Author: David Phillips
Publisher: Elsevier
ISBN: 0323161197
Category : Science
Languages : en
Pages : 73
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Book Description
Spermiogenesis summarizes the process of sperm structure and development in a variety of organisms. It attempts to illustrate the structure of the organelles that characterize mature spermatozoa and to trace the morphogenesis of these organelles during sperm formation. This task is complicated by considerable variations in the structure of spermatozoa among different species and the lack of good morphological studies of sperm structure and spermiogenesis in many animal groups. The general morphological features of mammalian sperm structure differ in some ways from the features of insect sperm, the spermatozoa produced by insects appearing relatively more simple. When the functions and developmental regions of the organelles are considered, homologies between complex structures found in mammalian sperm and simpler insect sperm structures may be deduced even though the organelles in question are quite dissimilar in appearance. Such homologies will be stressed in an effort to present as general a picture of spermiogenesis as seems consistent with the species-specific variations that exist. This book will be a useful, stimulating reference for students of reproductive biology.
Author: Daulat Tulsiani
Publisher: Springer Science & Business Media
ISBN: 146150273X
Category : Science
Languages : en
Pages : 405
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Book Description
Introduction to Mammalian Reproduction is a welcome contribution to the fields of gametogenesis, gamete transport, fertilization, and reproduction technologies. Key topics covered include: *formation and maturation of male gametes; *morphology and physiology of female gametes; *how the sperm meets the egg; *sperm-egg fusion, egg activation, and implantation of fertilized egg; *assisted reproduction and environmental chemicals that have an effect on formation and function of male and female gametes. This book is for both researchers and students involved in reproductive biology.
Author: John Edward Shorec Moore
Publisher:
ISBN:
Category :
Languages : en
Pages : 10
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Book Description
Author: Gautam Kaul
Publisher:
ISBN: 9781450705035
Category :
Languages : en
Pages :
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Book Description
