Author: James W. Allen
Publisher:
ISBN:
Category : Chromosome Aberrations
Languages : en
Pages : 504

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Author: Liane B. Russell
Publisher:
ISBN:
Category :
Languages : en
Pages : 88

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Author: JW Allen (Ed)
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Environmental Mutagen Information Center (U.S.)
Publisher:
ISBN:
Category : Chemical mutagenesis
Languages : en
Pages : 105

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Over 650 references; mostly journal articles dating from the 1960's to 1975. Also includes foreign-language literature. Arranged under Citation index, Agent index, Chemical abstracts service registry number index, Taxonomic index, Test object index, Mammalian germ cell assay systems index, Author index, and KWIC index. Entry in Citation index gives bibliographical information.

Author: Abraham W. Hsie
Publisher:
ISBN:
Category : Mammals
Languages : en
Pages : 392

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Author: Heide Schatten
Publisher: Springer Science & Business Media
ISBN: 1592597416
Category : Science
Languages : en
Pages : 421

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The study of germ cells has undergone enormous advances in recent years and has entered into an explosive phase of new discoveries with the introd- tion of transgenic technologies and nuclear cloning. Basic knowledge and te- niques developed for lower vertebrate and invertebrate systems have facilitated the study of higher vertebrates, including humans. Many experiments that have first been performed on lower vertebrates provided the tools and strategies that could later be applied to other less readily available mammalian systems. The discovery of centrosomes in ascidians and sea urchin eggs now benefits st- ies of fertility and infertility in mammals including humans. External in vitro fertilization, now a common technique in assisted fertilization has only been possible as a result of numerous studies in lower systems in which external fertilization is natural. Egg activation, first explored in sea urchin and asc- ian eggs, now benefits cloning efficiency in farm and domestic animals. Gene manipulations and molecular methods have added to the possibilities of p- ducing live offspring with enormous biomedical, ecological, and economic implications. All sexually reproducing organisms produce primordial germ cells, a small population of cells that differentiate into gametes of either sex that carry to- potency, an ability to develop into an entire new organism. The two volumes on germ cells combine techniques in a variety of different systems and have selected those systems that have provided landmarks in advancing our kno- edge on germ cells.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 80

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Mutagenesis by densely ionizing radiation represents a significant long-term hazard to the individual. Few data are available to describe the dose-response aspect of mutation induction by either accelerated charged particles or fission spectrum neutrons in mammalian germ cells. To address this question, an in vitro assay of dominant lethal mutations was undertaken for animals exposed to either of these radiation sources. Special emphasis was placed on the action in spermatogonial stem cells. The data indicate that mutations were induced as a linear function of dose and there was no evidence of a threshold. Mutagenesis was also detected in females given x-radiation. The induction curve had an initial steep linear aspect and then a less steep slope. As with male germ cells, there was no evidence of a threshold. The in vitro dominant lethal data were compared to various cytogenetic assays and were found to be more sensitive indicators of mutation. In preliminary studies, the rate of stable mutagenic damage appeared to be modifiable by pretreatment with chemotherapeutic drugs. Because the radiation sources chosen for this study are thought to be the most efficient for mutation induction, the values obtained may describe the upper limits of exposure for this endpoint. As applied to risk estimation, these data should be considered relative to the normal risk encountered and accepted by the population at large. Keywords: Exposure(Physiology), Irradiation.

Author: Monica Justice
Publisher: Springer Science & Business Media
ISBN: 1402050577
Category : Science
Languages : en
Pages : 98

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The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

Author: Carol Maria Ordille
Publisher:
ISBN:
Category : Lethal mutation
Languages : en
Pages : 164

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Author: F Vogel (Ed)
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 556

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