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Languages : en
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Author: Tanja Petnicki-Ocwieja
Publisher: Frontiers Media SA
ISBN: 2889195570
Category : Infectious and parasitic diseases
Languages : en
Pages : 116
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The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance. The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors. Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology. Here, several reviews will discuss the most recent advances and future studies to be undertaken in the field of B. burgdorferi biology.
Author: Judy Monroe
Publisher: Capstone
ISBN: 9780736807517
Category : Juvenile Nonfiction
Languages : en
Pages : 64
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Explains what Lyme disease is, what its symptoms are, and how it is spread. Also describes ways to avoid Lyme disease, as well as ways to treat it.
Author: Mary E. Williams
Publisher: Greenhaven Publishing LLC
ISBN: 0737764783
Category : Young Adult Nonfiction
Languages : en
Pages : 154
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If left untreated Lyme Disease can spread to joints, heart, and nervous system. This guidebook provides essential information on Lyme Disease, but also serves as a historical survey, by providing information on the controversies surrounding its causes, and first-person narratives by people coping with Lyme Disease. Patients, family members, or caregivers explain the condition from their own experience. The symptoms, causes, treatments, and potential cures are explained in detail. Essential to anyone trying to learn about diseases and conditions, the alternative treatments are explored. Each essay is carefully edited and presented with an introduction, so that they are accessible for student researchers and readers.
Author: Jonathan A. Edlow
Publisher: Yale University Press
ISBN: 9780300103700
Category : Health & Fitness
Languages : en
Pages : 324
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Book Description
Provides information on the history of Lyme disease focusing on the scientific processes involved in its discovery.
Author: John J Halperin
Publisher: CABI
ISBN: 1786392070
Category : Medical
Languages : en
Pages : 301
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Book Description
This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects. This new edition includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection. As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.
Author: Alan G. Barbour
Publisher: JHU Press
ISBN: 1421417227
Category : Health & Fitness
Languages : en
Pages : 297
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Book Description
A world-renowned Lyme disease expert explains everything you need to know if you live, work, or play in areas with the ticks that carry disease. Once restricted to small forested areas in the northeast and north-central United States, Lyme disease is now a common infection in North America and Europe. The Centers for Disease Control and Prevention estimate that more than 300,000 new cases occur each year in the United States. Misunderstandings over symptoms and treatment increase the public's concerns about the disease—which, if not properly treated, can become chronic and debilitating. An expert on tick-borne diseases, Alan G. Barbour explains the course of illness that results from infection, diagnosis and treatment options, and steps that can be taken to avoid a tick bite in the first place. The ticks that transmit Lyme disease may also transmit other disease-causing pathogens, and these other infections are considered as well. Drawing on real case histories of individuals with Lyme disease—or illnesses that may be mistaken for Lyme disease—Barbour explains: The biology of the spirochete, Borrelia burgdorferi, that causes Lyme disease The role of animals such as mice that carry the infection The life cycle of the ticks that transmit the infection The importance of deer in perpetuating the cycle The basics of diagnostic laboratory tests and how test results are interpreted How antibiotics are used in treating Lyme disease Infected ticks are abundant in the woods, in walking trails, and in the shrubs and tall grass where suburban lawns meet wooded areas. Barbour stresses preventing disease through community-wide ecology projects and individual and household protection. While it may be difficult to escape infection, understanding the danger, the symptoms, and the treatment goes a long way toward preventing long-term health consequences. Featuring a list of reliable web sites and a glossary of terms, Lyme Disease is an invaluable resource for everyone who is at risk of the disease or is involved in preventing and treating it.
Author: United States. General Accounting Office
Publisher:
ISBN:
Category : Health education
Languages : en
Pages : 48
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Author: Raymond J. Lampke
Publisher: Greenhaven Publishing LLC
ISBN: 1534563644
Category : Young Adult Nonfiction
Languages : en
Pages : 106
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Book Description
Lyme disease is not often discussed, which means the general public knows little about it. Many people are aware that it can be passed from ticks to humans, but questions remain. What are the symptoms? Is it contagious? Can it be treated? What are the best prevention methods? These questions and more are answered in this engaging book, with text that is enhanced with full-color photographs, annotated quotes, and informative sidebars. By fully informing themselves about this disease, readers will know the steps to take if they encounter it as well as how to support a loved one who contracts Lyme disease.
Author: Abigail A. Dumes
Publisher: Duke University Press
ISBN: 1478007397
Category : Social Science
Languages : en
Pages : 192
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Book Description
While many doctors claim that Lyme disease—a tick-borne bacterial infection—is easily diagnosed and treated, other doctors and the patients they care for argue that it can persist beyond standard antibiotic treatment in the form of chronic Lyme disease. In Divided Bodies, Abigail A. Dumes offers an ethnographic exploration of the Lyme disease controversy that sheds light on the relationship between contested illness and evidence-based medicine in the United States. Drawing on fieldwork among Lyme patients, doctors, and scientists, Dumes formulates the notion of divided bodies: she argues that contested illnesses are disorders characterized by the division of bodies of thought in which the patient's experience is often in conflict with how it is perceived. Dumes also shows how evidence-based medicine has paradoxically amplified differences in practice and opinion by providing a platform of legitimacy on which interested parties—patients, doctors, scientists, politicians—can make claims to medical truth.
