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Author: Harold G. Callan
Publisher: Springer Science & Business Media
ISBN: 3642827926
Category : Science
Languages : en
Pages : 263
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Book Description
In 1965 I was asked by Dr. Konrad Springer whether I would consider writing a monograph on "Lampbrush chromosomes and their physiological meaning", and although I accepted in principle I refused to write there and then, or to meet a deadline. I wanted to continue with my own research, and I had other responsibilities that left me with little free time, but a much more important consideration was that in the 1960s the subject was beset by a host of unresolved questions. I felt that to write a review then would be premature, full of speculations many of which would be refuted, and indeed were refuted, within the next decade or two. Had I written at that time the only real advantage over the present would have been that few biologists were studying lampbrush chromo somes, and the published literature was therefore scanty. I am glad that I insisted on delay, and am grateful for Springer Verlag's patient acceptance of my decision. The first chapter of this monograph describes the history of research on lampbrush chromosomes from their discovery towards the end of the 19th century until the early 1960s. By then several facts concerning their structure and chemistry had been firmly established, including the evidence that a lampbrush chromatid is unineme; it contains a single uninterrupted DNA duplex. This exposed a major problem, the C-value paradox; grades of complexity of organization in eukaryotes are unrelated to their genome sizes.
Author: Harold G. Callan
Publisher: Springer Science & Business Media
ISBN: 3642827926
Category : Science
Languages : en
Pages : 263
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Book Description
In 1965 I was asked by Dr. Konrad Springer whether I would consider writing a monograph on "Lampbrush chromosomes and their physiological meaning", and although I accepted in principle I refused to write there and then, or to meet a deadline. I wanted to continue with my own research, and I had other responsibilities that left me with little free time, but a much more important consideration was that in the 1960s the subject was beset by a host of unresolved questions. I felt that to write a review then would be premature, full of speculations many of which would be refuted, and indeed were refuted, within the next decade or two. Had I written at that time the only real advantage over the present would have been that few biologists were studying lampbrush chromo somes, and the published literature was therefore scanty. I am glad that I insisted on delay, and am grateful for Springer Verlag's patient acceptance of my decision. The first chapter of this monograph describes the history of research on lampbrush chromosomes from their discovery towards the end of the 19th century until the early 1960s. By then several facts concerning their structure and chemistry had been firmly established, including the evidence that a lampbrush chromatid is unineme; it contains a single uninterrupted DNA duplex. This exposed a major problem, the C-value paradox; grades of complexity of organization in eukaryotes are unrelated to their genome sizes.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Hsueh Jei Li
Publisher: Elsevier
ISBN: 0323153631
Category : Science
Languages : en
Pages : 372
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Book Description
Chromatin and Chromosome Structure consists of chapters that reflect a 1975 seminar course and the reported observations after the session. The seminar is organized for the benefit of both faculty and students in the Biology Ph.D. Program of the City University of New York. This book begins with a presentation of the conformational studies of histones. It then describes the histone-DNA interactions and the subunits isolated either from chromatin or from nuclei. It also explains the post-synthetic modifications of histone structure. Furthermore, the book talks about the chemistry and function of nuclear nonhistone proteins, low molecular weight nuclear RNA, and polytene chromosome structure. The regulation of gene expression in chick oviduct model system and the main features of lampbrush chromosomes are shown as well. Aside from the students and faculty of the above-mentioned university, this compilation will be invaluable as well to other undergraduate and graduate students; professors; and researchers. It will also be a good reference to those who are specializing in chromatin and chromosome studies.
Author: Wolfgang Hennig
Publisher: Springer Science & Business Media
ISBN: 3540477837
Category : Science
Languages : en
Pages : 332
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Book Description
This book presents an overview of various aspects of chromosome research, written by leading experts of the respective fields, combining classic and recent molecular biological results. The variety and comprehensiveness make it a handbook of chromosome research for all scientists, teachers and graduate students interested in this field. Dieses Buch faßt die unterschiedlichen Aspekte der Chromosomenforschung in Beiträgen von führenden Wissenschaftlern zusammen, wobei die klassischen Erkenntnisse mit neuesten Forschungsdaten zu einem umfassenden Überblick über das Gebiet kombiniert werden.
Author: Adrian T. Sumner
Publisher: John Wiley & Sons
ISBN: 0470695226
Category : Science
Languages : en
Pages : 304
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Book Description
Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.
Author: Arun Sharma
Publisher: Butterworth-Heinemann
ISBN: 1483100847
Category : Science
Languages : en
Pages : 724
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Book Description
Chromosome Techniques: Theory and Practice, Third Edition focuses on chromosome research. The book first discusses pre-treatment and hypotonic treatment. Pre-treatment for clearing the cytoplasm and softening the tissues; separation of chromosomes and clarification of constrictions; and hypotonic treatment for chromosome spread are described. The text also explains fixation and processing, including fixing of fluids and mixtures and air-drying techniques for chromosome study. The selection also discusses methods for special materials. Study of division in embryosac mother cells; study of chromosomes from thallophytes; salivary gland, lamp brush, and pachytene chromosomes; spiral structure; and secondary constriction are explained. The text also discusses microscopy, including ordinary light microscopy, high resolution autoradiography, and light microscope autoradiography. The book discusses study of plant chromosomes from tissue culture; chromosome analysis following short- and long-term cultures in animals, including man; and chromosome analysis from malignant tissues. The text takes a look at the banding patterns of chromosomes, including banding pattern techniques, C-banding, and representative schedules for comparative study of different banding patterns. The book further describes somatic cell fusion and the chemical nature of chromosomes, proteins, and enzymes. The text is a vital source of information for readers wanting to conduct research on chromosomes.
Author: Thomas Liehr
Publisher: Springer Science & Business Media
ISBN: 3540705813
Category : Science
Languages : en
Pages : 447
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Book Description
This book is a unique source of information on the present state of the exciting field of molecular cytogenetics and how it can be applied in research and diagnostics. The basic techniques of fluorescence in situ hybridization and primed in situ hybridization (PRINS) are outlined, the multiple approaches and probe sets that are now available for these techniques are described, and applications of them are presented in 36 chapters by authors from ten different countries around the world. The book not only provides the reader with basic and background knowledge on the topic, but also gives detailed protocols that show how molecular cytogenetics is currently performed by specialists in this field. The FISH Application Guide initially provides an overview of the (historical) development of molecular cytogenetics, its basic procedures, the equipment required, and probe generation. The book then describes tips and tricks for making different tissues available for molecular cytogenetic studies. These are followed by chapters on various multicolor FISH probe sets, their availability, and their pot- tial for use in combination with other approaches. The possible applications that are shown encompass the characterization of marker chromosomes, cryptic cytogenetic aberrations and epigenetic changes in humans by interphase and metaphase cyto- netics, studies of nuclear architecture, as well as the application of molecular cytogenetics to zoology, botany and microbiology.
Author: J. Schulz-Schaeffer
Publisher: Springer Science & Business Media
ISBN: 1461260604
Category : Science
Languages : en
Pages : 453
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Book Description
Since 1961 the author has taught a course in Cytogenetics at Montana State University. Undergraduate and graduate stu dents of Biology, Chemistry, Microbiology, Animal and Range Science, Plant and Soil Science, Plant Pathology and Veterinary Science are enrolled. Therefore, the subject matter has been pre sented in an integrated way to correlate it with these diverse disciplines. This book has been prepared as a text for this course. The most recent Cytogenetics text was published in 1972, and rapidly developing research in this field makes a new one urgently needed. This book includes many aspects of Cytogenetics and related fields and is written for the college student as well as for the researcher. It is recommended that the student should have taken preparatory courses in Principles of Genetics and Cytol ogy. The content is more than is usually taught during one quar ter of an academic year, thus allowing an instructor to choose what he or she would like to present to a class. This approach also allows the researcher to obtain a broad exposure to this field of biology. References are generously supplied to stimulate orig inal reading on the subject and to give access to valuable sources. The detailed index is intended to be of special assistance to researchers.
Author: H.C. Macgregor
Publisher: Springer Science & Business Media
ISBN: 9780412546006
Category : Medical
Languages : en
Pages : 260
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Book Description
This book presents animal cytology as a science of seeing and interpreting chromosome form and behaviour, and of appreciating its evolutionary significance. Its principal objective is to help students develop a basic understanding and confidence on all matters relating to animal chromosomes.
Author: Stanley Maloy
Publisher: Academic Press
ISBN: 0080961568
Category : Science
Languages : en
Pages : 4360
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Book Description
The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics
