Is Cancer Inevitable?

Is Cancer Inevitable? PDF Author: Ashani T. Weeraratna
Publisher: JHU Press
ISBN: 1421442752
Category : Health & Fitness
Languages : en
Pages : 155

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Book Description
How can new understandings about cancer cell interactions help doctors better control, and eventually cure, cancer? Cancer is a formidable enemy. In fact, people born in America since 1960 face a one in two chance of being diagnosed with cancer in their lifetimes. However, there's growing evidence that fewer cancers will be death sentences for patients. New approaches and understandings are transforming the medical world, increasing success rates for remissions, disease management, and cures. Dr. Ashani Weeraratna is at the forefront of this new level of care. In Is Cancer Inevitable?, Weeraratna—a pioneering melanoma researcher whose work explores the role aging plays in cancer cells' spread and drug resistance—gives readers an inside look at several of the latest cancer advances. Detailing the actions that are reducing the disease's impact and exploring what the future may hold, she explains how the molecular mechanisms involved in metastasis and the cells' microenvironments influence cancer's development and progression. Over the years, she writes, our understanding of how cancer cells move throughout the body, change as they plant themselves in the body's microenvironments, and even communicate with one another have led to major insights about how cancer works. With compelling detail, she takes us inside her lab, revealing how new insights are leading to major breakthroughs, even among patients with Stage IV cancer. She also explains how age-related changes in the microenvironment contribute to multiple aspects of melanoma formation and development. Such scholarship, she argues, is moving us toward a day when more patients will be declared cancer-free. An inspiring and deeply personal book, Is Cancer Inevitable? offers readers newfound hope. Features • Explores key insights and studies developed in recent years that have greatly influenced the world of cancer research, including how aging microenvironments within our bodies encourage metastasis and therapy resistance • Guides readers through Dr. Ashani Weeraratna's personal story of coming to the United States from Lesotho at the age of 17 and rising to become one of the pioneers in her field • Brings readers inside Weeraratna's lab, describing both the processes and the missions of her work • Raises awareness about how cancer works within the body and what any patient or family encountering the disease needs to understand—while also offering them hope based on new and forthcoming diagnostic and treatment methods • Outlines why we will never control—let alone cure—cancer if we don't find a common purpose and come together in collaboration, inviting the greatest minds from around the world to participate in finding and implementing solutions Johns Hopkins Wavelengths In classrooms, field stations, and laboratories in Baltimore and around the world, the Bloomberg Distinguished Professors of Johns Hopkins University are opening the boundaries of our understanding of many of the world's most complex challenges. The Johns Hopkins Wavelengths book series brings readers inside their stories, illustrating how their pioneering discoveries benefit people in their neighborhoods and across the globe in artificial intelligence, cancer research, food systems' environmental impacts, health equity, science diplomacy, and other critical arenas of study. Through these compelling narratives, their insights will spark conversations from dorm rooms to dining rooms to boardrooms.

Is Cancer Inevitable?

Is Cancer Inevitable? PDF Author: Ashani T. Weeraratna
Publisher: JHU Press
ISBN: 1421442752
Category : Health & Fitness
Languages : en
Pages : 155

Get Book

Book Description
How can new understandings about cancer cell interactions help doctors better control, and eventually cure, cancer? Cancer is a formidable enemy. In fact, people born in America since 1960 face a one in two chance of being diagnosed with cancer in their lifetimes. However, there's growing evidence that fewer cancers will be death sentences for patients. New approaches and understandings are transforming the medical world, increasing success rates for remissions, disease management, and cures. Dr. Ashani Weeraratna is at the forefront of this new level of care. In Is Cancer Inevitable?, Weeraratna—a pioneering melanoma researcher whose work explores the role aging plays in cancer cells' spread and drug resistance—gives readers an inside look at several of the latest cancer advances. Detailing the actions that are reducing the disease's impact and exploring what the future may hold, she explains how the molecular mechanisms involved in metastasis and the cells' microenvironments influence cancer's development and progression. Over the years, she writes, our understanding of how cancer cells move throughout the body, change as they plant themselves in the body's microenvironments, and even communicate with one another have led to major insights about how cancer works. With compelling detail, she takes us inside her lab, revealing how new insights are leading to major breakthroughs, even among patients with Stage IV cancer. She also explains how age-related changes in the microenvironment contribute to multiple aspects of melanoma formation and development. Such scholarship, she argues, is moving us toward a day when more patients will be declared cancer-free. An inspiring and deeply personal book, Is Cancer Inevitable? offers readers newfound hope. Features • Explores key insights and studies developed in recent years that have greatly influenced the world of cancer research, including how aging microenvironments within our bodies encourage metastasis and therapy resistance • Guides readers through Dr. Ashani Weeraratna's personal story of coming to the United States from Lesotho at the age of 17 and rising to become one of the pioneers in her field • Brings readers inside Weeraratna's lab, describing both the processes and the missions of her work • Raises awareness about how cancer works within the body and what any patient or family encountering the disease needs to understand—while also offering them hope based on new and forthcoming diagnostic and treatment methods • Outlines why we will never control—let alone cure—cancer if we don't find a common purpose and come together in collaboration, inviting the greatest minds from around the world to participate in finding and implementing solutions Johns Hopkins Wavelengths In classrooms, field stations, and laboratories in Baltimore and around the world, the Bloomberg Distinguished Professors of Johns Hopkins University are opening the boundaries of our understanding of many of the world's most complex challenges. The Johns Hopkins Wavelengths book series brings readers inside their stories, illustrating how their pioneering discoveries benefit people in their neighborhoods and across the globe in artificial intelligence, cancer research, food systems' environmental impacts, health equity, science diplomacy, and other critical arenas of study. Through these compelling narratives, their insights will spark conversations from dorm rooms to dining rooms to boardrooms.

Molecular Biology of The Cell

Molecular Biology of The Cell PDF Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0

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Book Description


Living with Hereditary Cancer Risk

Living with Hereditary Cancer Risk PDF Author: Kathy Steligo
Publisher: JHU Press
ISBN: 1421444259
Category : Health & Fitness
Languages : en
Pages : 496

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Book Description
"This book provides a comprehensive overview of hereditary cancer for a general audience, with coverage of the genetic tests available for detecting risk for heritable cancers as well as options for medical and surgical treatment"--

The Cheating Cell

The Cheating Cell PDF Author: Athena Aktipis
Publisher: Princeton University Press
ISBN: 0691163847
Category : Medical
Languages : en
Pages : 256

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Book Description
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

The Cancer Chronicles

The Cancer Chronicles PDF Author: George Johnson
Publisher: Vintage
ISBN: 0385349718
Category : Medical
Languages : en
Pages : 305

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Book Description
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

Oxford Textbook of Cancer Biology

Oxford Textbook of Cancer Biology PDF Author: Francesco Pezzella
Publisher: Oxford University Press
ISBN: 0198779453
Category : Medical
Languages : en
Pages : 505

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Book Description
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

Reducing Environmental Cancer Risk

Reducing Environmental Cancer Risk PDF Author: Suzanne H. Reuben
Publisher: DIANE Publishing
ISBN: 1437934218
Category : Health & Fitness
Languages : en
Pages : 240

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Book Description
Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.

The Emperor of All Maladies

The Emperor of All Maladies PDF Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1439170916
Category : Health & Fitness
Languages : en
Pages : 624

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Book Description
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Confronting Hereditary Breast and Ovarian Cancer

Confronting Hereditary Breast and Ovarian Cancer PDF Author: Sue Friedman
Publisher: JHU Press
ISBN: 1421404451
Category : Health & Fitness
Languages : en
Pages : 320

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Book Description
"Be informed. Be empowered. Be well." If you are concerned that the cancer in your family is hereditary, you face difficult choices. Should you have a blood test that may reveal whether you have a high likelihood of disease? Do you preemptively treat a disease that may never develop? How do you make decisions now that will affect the rest of your life? This helpful, informative guide answers your questions as you confront hereditary breast and ovarian cancer. Developed by Facing Our Risk of Cancer Empowered (FORCE), the nation’s only nonprofit organization dedicated to supporting families affected by hereditary breast and ovarian cancer, this book stands alone among breast and ovarian cancer resources. Equal parts health guide and memoir, it defines complex issues facing previvors and survivors and provides solutions with a fresh, authoritative voice. Written by three passionate advocates for the hereditary cancer community who are themselves breast cancer survivors, Confronting Hereditary Breast and Ovarian Cancer dispels myths and misinformation and presents practical risk-reducing alternatives and decision-making tools. Including information about genetic counseling and testing, preventive surgery, and fertility and family planning, as well as explanations of health insurance coverage and laws protecting genetic privacy, this resource tackles head-on the challenges of living in a high-risk body. Confronting hereditary cancer is a complex, confusing, and highly individual journey. With its unique combination of the latest research, expert advice, and compelling personal stories, this book gives previvors, survivors, and their family members the guidance they need to face the unique challenges of hereditary cancer.

Avoiding Cancer One Day at a Time

Avoiding Cancer One Day at a Time PDF Author: Lynne Eldridge
Publisher: Avoiding Cancer Now
ISBN: 1592981593
Category : Family & Relationships
Languages : en
Pages : 322

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Book Description
The mortality rate from cancer hasn't changed in 60 years despite the billions invested to find a cure. Avoiding Cancer One Day At A Time provides solid, practical advice for preventing cancer by avoiding carcinogens and implementing lifestyle/dietary practices that modify cancer causing factors. Combining their experience in family medicine and epidemiology with their passion for disease prevention, the authors provide the most up to date and effective advice for preventing cancer from developing in ourselves and our loved ones. Many ?how to? examples for preventing cancer by being environmentally aware, avoiding infections, living the proper lifestyle and getting the proper nutrition are provided. Chapter by chapter summaries and listings of the latest cancer prevention web sites are great references. Worksheets assist readers in implementing the advice in very tangible ways, and the recipe collection of cancer avoiding meals is a winner!