Iron Mediated C-C and C-N Bond Forming Reactions in the Total Synthesis of Epi-cantabricine and Hippadine PDF Download
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Author: Salima Filali
Publisher:
ISBN:
Category :
Languages : en
Pages : 113
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Author: Salima Filali
Publisher:
ISBN:
Category :
Languages : en
Pages : 113
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Author: Vijaykumar Kanuru
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Alan Graham
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Arkadi Vigalok
Publisher: Springer
ISBN: 3642120733
Category : Science
Languages : en
Pages : 198
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Contents: Kilian Muñiz: Transition Metal Catalyzed Electrophilic Halogenation of C-H bonds in alpha-Position to Carbonyl Groups; Arkadi Vigalok * and Ariela W Kaspi: Late Transition Metal-Mediated Formation of Carbon-Halogen Bonds; Paul Bichler and Jennifer A. Love*: Organometallic Approaches to Carbon-Sulfur Bond Formation; David S. Glueck: Recent Advances in Metal-Catalyzed C-P Bond Formation; Andrei N. Vedernikov: C-O Reductive Elimination from High Valent Pt and Pd Centers; Lukas Hintermann: Recent Developments in Metal-Catalyzed Additions of Oxygen Nucleophiles to Alkenes and Alkynes; Moris S. Eisen: Catalytic C-N, C-O and C-S bond formation promoted by organoactinide complexes.
Author:
Publisher: Elsevier
ISBN: 044323700X
Category : Science
Languages : en
Pages : 338
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Book Description
Enantioselective C-C Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to Chirality, Metal-catalyzed stereoselective C-C-bond forming reactions, Enantioselective C-C bond forming reactions promoted by organocatalysts based on unnatural amino acid derivatives, Enantioselective C-C bond formation in complex multicatalytic system, Gold-based multicatalytic systems for enantioselective C-C Bond forming reactions, Novel enzymatic tools for C-C bond formation through the development of new-to-nature biocatalysis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Catalysis serials - Updated release includes the latest information in the field
Author: Rui Shang
Publisher: Springer
ISBN: 9811031932
Category : Science
Languages : en
Pages : 225
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This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation. The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner.
Author: Xavi Ribas
Publisher: Royal Society of Chemistry
ISBN: 1849737169
Category : Science
Languages : en
Pages : 489
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Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron – an emerging element in this field. Reviewing the recent literature, the book presents an in-depth understanding of the field, guiding the reader to achieving the best synthetic strategies for aromatic functionalisation. Organic and Organometallic chemists, as well as natural product and pharmaceutical scientists, will find this an essential guide to a major transformation currently underway in synthetic chemistry.
Author: Te-Yu Chen (Ph. D.)
Publisher:
ISBN:
Category :
Languages : en
Pages : 1236
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One of the more formidable challenges of organic synthesis remains the efficient construction of C-C bonds. A generally used strategy for carrying out such transformations involves the addition of carbon-based nucleophiles to carbonyl and/or imine compounds. However, the forementioned approaches to C-C bond formation suffer various drawbacks; for instance, the use of stoichiometric pre-formed organometallic reagents and in the meanwhile generates stoichiometric organometallic byproducts. In order to bypass nucleophile pre-activation and byproduct formation, multiple efficient methods for carbonyl and/or imine additions via in situ formation of organometallic nucleophiles from [greek letter pi]-unsaturates have been developed in the Krische group. The research presented in this dissertation describes our advances in transition metal-catalyzed C-C bond forming reactions mediated through transfer hydrogenative process, including regioselective hydrohydroxyalkylation and hydroaminoalkylation. Additionally, studies toward the total synthesis of bryostatin analogue are described.
Author: Donghui Wang
Publisher:
ISBN:
Category : Activation (Chemistry)
Languages : en
Pages : 1108
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This thesis is focus on solving several limitations that remain in C-H activation reactions, and seek several more practical and synthetic useful processes. The Pd-catalyzed C-H acetoxylation protocol that is compatible with a wide range of N-methyl amines directed by Boc or pivaloyl groups. Both alkyl and aniline substrates were found to give high yields. The mechanistic data are consistent with [sigma-chelation-assisted sp3 C-H insertion. We developed the first protocol for the coupling of sp3 C-H bonds with both sp2 and sp3 boronic acids. The cross-coupling of methoxyamide with boronic acid provided mono-selectivity, which will benefit the synthetic community. We could use atmospheric oxygen as oxidant. We developed a practical and general protocol for C-H activation/aryl-aryl coupling using aryltrifluoroborates. This new protocol substantially expanded the benzoic acid substrate scope and made it possible. We demonstrated the importance of ligand development for enabling unique reactivity and positional selectivity in C-H activation and at the same time, to illustrate two conceptual prerequisites for widespread application of Pd-catalyzed C-H activation in organic synthesis: (1) versatile substrates and coupling partners and (2) precise control of positional selectivity in C-H functionalization. We anticipate that this C-H olefination reaction and others grounded in this philosophy will find broad applicability in multifarious synthetic endeavors. Using C-H olefination protocol, we developed a concise synthesis of natural product lithospermic acid by taking advantage of two successive C-H activation reactions as key steps. The use of C-H activation in natural product synthesis is obviously beneficial in terms of streamlining syntheses, generally both in terms of step count and atom economy.
Author: Stephen D. Goble
Publisher:
ISBN:
Category :
Languages : en
Pages :
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