Investigation Into the Mechanisms of Hydrogen Sulfide Signaling in the Cardiovascular System and the Effects of Age and Caloric Restriction PDF Download
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Author: Benjamin Lee Predmore
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Aorta CSE and CBS mRNA expression was higher with CR. Hydrogen sulfide production was also higher with CR in aorta and liver. I conclude that in rat aorta the triphasic responses to hypoxia and H2S are mediated by different mechanisms, hydrogen sulfide up-regulates eNOS/NO production through an Akt-dependent mechanism, and the increased sensitivity to hydrogen sulfide and increased protein expression of CSE and CBS with age in aorta point to a drop in hydrogen sulfide bioavailability, while CR maintains CSE/CBS function. These studies reveal novel, age-sensitive mechanisms of hydrogen sulfide action to regulate vascular tone. They also illustrate the benefit of CR on the hydrogen sulfide signaling system. This is quite timely, given the emerging roles of hydrogen sulfide in cardiovascular pathologies.
Author: Benjamin Lee Predmore
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Aorta CSE and CBS mRNA expression was higher with CR. Hydrogen sulfide production was also higher with CR in aorta and liver. I conclude that in rat aorta the triphasic responses to hypoxia and H2S are mediated by different mechanisms, hydrogen sulfide up-regulates eNOS/NO production through an Akt-dependent mechanism, and the increased sensitivity to hydrogen sulfide and increased protein expression of CSE and CBS with age in aorta point to a drop in hydrogen sulfide bioavailability, while CR maintains CSE/CBS function. These studies reveal novel, age-sensitive mechanisms of hydrogen sulfide action to regulate vascular tone. They also illustrate the benefit of CR on the hydrogen sulfide signaling system. This is quite timely, given the emerging roles of hydrogen sulfide in cardiovascular pathologies.
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
ISBN:
Category : Government publications
Languages : en
Pages : 728
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Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Philip K. Moore
Publisher: Springer
ISBN: 3319181440
Category : Medical
Languages : en
Pages : 384
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Book Description
This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.
Author: Harry D. Peck
Publisher: Academic Press
ISBN:
Category : Science
Languages : en
Pages : 728
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Book Description
This volume presents methods related to the role of anaerobic dissimilatory cycles and sulfur metabolism. Sulfate Transport Dissimilatory Sulfate Metabolism Dehydrogenases Hydrogenases from sulfate-reducing bacteria Electron carrier protein sulfate-reducing bacteria Terminal reductases of sulfate-reducing bacteria molecular biology Dissimilatory sulfur reduction Oxidation of reduction compounds Metabolism of polythinates Special techniques
Author: E. I. Sokolov
Publisher: VSP
ISBN: 9789067642125
Category : Medical
Languages : en
Pages : 338
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Book Description
This book is the result of the study of metabolic and hormonal disorders in patients suffering obesity and diabetes mellitus, focusing on mechanisms of formation of atherosclerotic changes in the myocardium and vessels in diabetes mellitus patient.
Author:
Publisher: Academic Press
ISBN: 0080581307
Category : Medical
Languages : en
Pages : 734
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Book Description
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. Contains cutting-edge information on focused topics written by expert scientists Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines Attempts molecular pathophysiology which links basic science and the clinic Presents critical assessment of controversial topics
Author:
Publisher:
ISBN:
Category : Demethylnitrosamine
Languages : en
Pages : 136
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Book Description
Author: Felipe Sierra
Publisher: Springer
ISBN: 3319232460
Category : Medical
Languages : en
Pages : 637
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Book Description
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Author: Isabella Dalle-Donne
Publisher: John Wiley & Sons
ISBN: 0471973114
Category : Science
Languages : en
Pages : 978
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Book Description
Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.
Author: H. Böhles
Publisher: CRC Press
ISBN: 9783887631048
Category : Cardiomyopathy
Languages : en
Pages : 188
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Book Description
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
