In Vivo Migration of Immune Cells

In Vivo Migration of Immune Cells PDF Author: Waldemar L. Olszewski
Publisher: CRC Press
ISBN: 1000006255
Category : Health & Fitness
Languages : en
Pages : 274

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Book Description
First Published in 1987: The problems which have been selected for this volume deal with those most commonly observed in in vivo events, such as antigenic stimulation and lymphocyte traffic, migration of natural killer cells, regulation of lymphocyte traffic by adrenal hormones.

In Vivo Migration of Immune Cells

In Vivo Migration of Immune Cells PDF Author: Waldemar L. Olszewski
Publisher: CRC Press
ISBN: 1000006255
Category : Health & Fitness
Languages : en
Pages : 274

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Book Description
First Published in 1987: The problems which have been selected for this volume deal with those most commonly observed in in vivo events, such as antigenic stimulation and lymphocyte traffic, migration of natural killer cells, regulation of lymphocyte traffic by adrenal hormones.

Immune Cell Migration in Health and Disease

Immune Cell Migration in Health and Disease PDF Author: Hélène D. Moreau
Publisher: Frontiers Media SA
ISBN: 288976088X
Category : Medical
Languages : en
Pages : 178

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Book Description


Labeling of Immune Cells for in Vivo Monitoring of Cell Migration Using Magnetic Resonance Imaging and Near-infrared Imaging

Labeling of Immune Cells for in Vivo Monitoring of Cell Migration Using Magnetic Resonance Imaging and Near-infrared Imaging PDF Author: Cedric Berger
Publisher:
ISBN:
Category :
Languages : en
Pages : 173

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Book Description


Cell Migration in Inflammation and Immunity

Cell Migration in Inflammation and Immunity PDF Author: Daniele D’Ambrosio
Publisher: Springer Science & Business Media
ISBN: 1592594352
Category : Medical
Languages : en
Pages : 283

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Book Description
Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angiogenesis, tissue architecture, and organogenesis. The basis for such diversified activities rests, on one hand, upon the ubiquitous nature of chemokine production and chemokine receptor expression. Virtually every cell type can produce chemokines and expresses a unique combination of chemokine receptors. On the other hand, chemokine receptors make use of a flexible and complex network of intracellular signaling machineries that can regulate a variety of cellular functions ranging from cell migration, growth, and differentiation to death. As knowledge of the size of chemokine and chemokine receptor families rapidly reaches completeness, much is still to be uncovered in terms of fu- tional architecture of the chemokine system. The disparity between the large number of chemokines and that smaller number of receptors is balanced by the promiscuity in ligand–receptor interactions, with multiple chemokines binding to the same receptor and several chemokines binding to more than one receptor.

Arrest chemokines

Arrest chemokines PDF Author: Klaus Ley
Publisher: Frontiers Media SA
ISBN: 2889194302
Category : Chemokines
Languages : en
Pages : 109

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Book Description
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.

In Vivo Generation and Migration of Memory CD4+ T Cells During the Course of a Primary Immune Response

In Vivo Generation and Migration of Memory CD4+ T Cells During the Course of a Primary Immune Response PDF Author: Richard Lee Reinhardt
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 344

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Book Description


Janeway's Immunobiology

Janeway's Immunobiology PDF Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :

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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

PI3K signalling

PI3K signalling PDF Author: Klaus Okkenhaug
Publisher: Frontiers Media SA
ISBN: 2889194191
Category : Immunologic diseases. Allergy
Languages : en
Pages : 140

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Book Description
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

In Vivo Migration of Immune Cells

In Vivo Migration of Immune Cells PDF Author: Waldemar L. Olszewski
Publisher: CRC Press
ISBN: 1000013073
Category : Health & Fitness
Languages : en
Pages : 432

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Book Description
First Published in 1987: The problems which have been selected for this volume deal with those most commonly observed in in vivo events, such as antigenic stimulation and lymphocyte traffic, migration of natural killer cells, regulation of lymphocyte traffic by adrenal hormones.

Cell Migration in Inflammation and Immunity

Cell Migration in Inflammation and Immunity PDF Author: Daniele D'Ambrosio
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
Cell migration is now well recognized as a critical component of the inflammatory disease process, so that its proper understanding promises to generate both ground-breaking basic discoveries and the development of novel therapeutics. In Cell Migration in Inflammation and Immunity: Methods and Protocols, leading cell biologists and immunologists present their most widely useful and innovative techniques for studying the molecular and cellular basis of this phenomenon. Describing each method in step-by-step detail, the authors provide a series of focused, cutting-edge techniques proceeding from the in vitro analysis of cell migration and the molecular mechanisms underlying this process, to methodologies for the analysis of cell migration in vivo. Methods for the analysis of rapid leukocyte adhesion under flow conditions in vitro are described, which may prove especially fruitful for scientists exploring the molecular mechanisms underlying both vascular recognition and leukocyte-endothelium interaction. Experimental approaches useful in establishing the role of cell migration in the pathogenesis of both acute and chronic inflammatory diseases are emphasized. Each fully tested protocol includes an introduction explaining the principle behind the technique, equipment and reagent lists, and tips on troubleshooting and how to avoid known pitfalls. Comprehensive and cutting-edge, Cell Migration in Inflammation and Immunity: Methods and Protocols offers novice and experienced investigators alike a collection of powerful techniques for studying the molecular basis and pathophysiological significance of cell migration in inflammatory and immune diseases, as well as for the development of novel therapeutics.