Immunopathogenetic Aspects of Disease Induced by Helminth Parasites PDF Download
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Author: David O. Freedman
Publisher: Karger Medical and Scientific Publishers
ISBN: 9783805564007
Category : Medical
Languages : en
Pages : 252
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Book Description
Just as the magnitude of the growth and developmental problems attributable to human helminthiasis are being fully realized, we are able for the first time to describe defined immune responses giving rise to the pathological lesions seen. On the basis of the different sets of cytokines produced by CD4+ T cells, these responses can be classified according to the Th1/Th2/Th0 paradigm. Deleterious inflammatory responses to metazoan parasites appear to be consistently associated with a highly polarized Th2 cytokine profile. Thus, host-parasite models involving specific enteric and tissue helminths have provided seminal data on immunoregulatory and immunopathogenetic responses that are more broadly generalizable to the entire Th1/Th2 paradigm. The first three articles in this volume present an overview of recent advances in the understanding of the induction of IgE, eosinophilic, and cytokine regulatory responses to helminthic infection. Subsequent articles comprehensively review immunopathogenetic aspects of schistosomiasis, hookworm infection, echinococcosis, lymphatic filariasis, onchocerciasis, toxocariasis, and cysticercosis, and, at the same time, emphasize key directions and priorities. Conclusions from animal models of infection are set in the context of human disease wherever possible. For all immunologists with an interest in cytokine biology and for those interested in the biology of tropical infectious diseases this volume is essential reading.
Author: David O. Freedman
Publisher: Karger Medical and Scientific Publishers
ISBN: 9783805564007
Category : Medical
Languages : en
Pages : 252
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Book Description
Just as the magnitude of the growth and developmental problems attributable to human helminthiasis are being fully realized, we are able for the first time to describe defined immune responses giving rise to the pathological lesions seen. On the basis of the different sets of cytokines produced by CD4+ T cells, these responses can be classified according to the Th1/Th2/Th0 paradigm. Deleterious inflammatory responses to metazoan parasites appear to be consistently associated with a highly polarized Th2 cytokine profile. Thus, host-parasite models involving specific enteric and tissue helminths have provided seminal data on immunoregulatory and immunopathogenetic responses that are more broadly generalizable to the entire Th1/Th2 paradigm. The first three articles in this volume present an overview of recent advances in the understanding of the induction of IgE, eosinophilic, and cytokine regulatory responses to helminthic infection. Subsequent articles comprehensively review immunopathogenetic aspects of schistosomiasis, hookworm infection, echinococcosis, lymphatic filariasis, onchocerciasis, toxocariasis, and cysticercosis, and, at the same time, emphasize key directions and priorities. Conclusions from animal models of infection are set in the context of human disease wherever possible. For all immunologists with an interest in cytokine biology and for those interested in the biology of tropical infectious diseases this volume is essential reading.
Author: Kara Filbey
Publisher: Frontiers Media SA
ISBN: 288966712X
Category : Science
Languages : en
Pages : 264
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Book Description
Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Author: Sydney Cohen
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 536
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Book Description
Author: Fabrizio Bruschi
Publisher: Springer
ISBN: 3709117828
Category : Medical
Languages : en
Pages : 509
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Book Description
Helminths are long-lived multicellular organisms that have co-evolved with humans over many thousands of years. They are responsible for infections which affect around one third of the human population, at global level. Despite the huge efforts in research during the last years, effective control of helminth infections is still far from optimal standards and the resulting diseases remain neglected. This book aims to give an up-date overview to the epidemiology (including molecular typing), specific biological, immunological and immunopathological aspects, diagnosis and perspectives of control of the most common helminth infections.
Author: William Hay Taliaferro
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 462
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Book Description
Author: Emilio Jirillo
Publisher: Immune Response to Parasitic I
ISBN: 9781608059898
Category : Medical
Languages : en
Pages : 272
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Book Description
This volume covers research on the interaction of major helminth parasites with the immune system. The main focus of the e-book is the ability of helminths to subvert host immune responses, on the one hand. On the other hand, the immunological armamentarium of the host against invading parasites is described also in the light of new findings on innate and adaptive immunity. These include the discovery of a new category of lymphocytes, innate lymphoid cells, and the role of T helper cels such as Th1, Th2 and Th3 cells, T regulatory (Treg) and Th17 cells in helminth diseases and inflammation. The balance between these two T cell subsets during the various stages of helminth diseases is also discussed. The book concludes with a review of new therapeutic approaches to combat helminth parasites (biotherapy, vaccines and natural products). Immunity to Helminths and Novel Therapeutic Approaches provides updated information for medical students, clinicians and researchers in the fields of parasitology, applied immunology and novel drug delivery.
Author: Michael J. Parnham
Publisher: Springer Nature
ISBN: 3030108112
Category : Medical
Languages : en
Pages : 888
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Book Description
Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
Author: Celia V. Holland
Publisher: Springer Science & Business Media
ISBN: 0306473836
Category : Science
Languages : en
Pages : 341
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Book Description
The soil-transmitted nematode parasites, or geohelminths, are - called because they have a direct life cycle, which involves no intermediate hosts or vectors, and are transmitted by faecal contamination of soil, foodstuffs and water supplies. They all inhabit the intestine in their adult stages but most species also have tissue-migratoryjuvenile stages, so the disease manifestations they cause can therefore be both local and systemic. The geohelminths together present an enormous infection burden on humanity. Those which cause the most disease in humans are divided into three main groupings, Ascaris lumbricoides (the large roundworm), Trichuris trichiura (whipworm), and the blood-feeding hookworms (Ancylostoma duodenale and Necator americanus ), and this book concentrates on these. These intestinal parasites are highly prevalent worldwide, A. lumbricoides is estimated to infect 1471 million (over a quarter ofthe world’s population), hookworms 1277 million, and T. trichiura 1049 million. The highly pathogenic Strongyloides species might also be classified as geohelminths, but they are not dealt with here because the understanding of their epidemiology, immunology and genetics has not advanced as rapidly as for the others. This is primarily because of the often covert nature of the infections, with consequent difficulties for analysis. If there is ever a second edition of this book, then there will hopefully be much to say about this infection.
Author: Celia Holland
Publisher: CABI
ISBN: 1845930266
Category : Science
Languages : en
Pages : 313
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Book Description
This book contains 19 chapters focusing on Toxocara and the disease it causes known as toxocariasis. The chapters are divided into the following parts: molecular biology (3 chapters); Toxocara as a model system (2); animal models for toxocariasis (1); human disease (4); immunology of toxocariasis (2); epidemiology of toxocariasis (3); Toxocara in the veterinary context (3); economic impact of the disease (1). It will interest a wide range of general, veterinary and medical parasitologists as well as clinicians and those concerned with public health.
Author: Alan Gunn
Publisher: John Wiley & Sons
ISBN: 1119945089
Category : Medical
Languages : en
Pages : 416
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Book Description
Parasitology: An Integrated Approach, provides a concise, student-friendly account of parasites and parasite relationships that is supported by case studies and suggestions for student projects. The book focuses strongly on parasite interactions with other pathogens and in particular parasite-HIV interactions, as well as looking at how host behaviour contributes to the spread of infections. There is a consideration of the positive aspects of parasite infections, how humans have used parasites for their own advantage and also how parasite infections affect the welfare of captive and domestic animals. The emphasis of Parasitology is on recent research throughout and each chapter ends with a brief discussion of future developments. This text is not simply an updated version of typical parastitology books but takes an integrated approach and explains how the study of parasites requires an understanding of a wide range of other topics from molecular biology and immunology to the interactions of parasites with both their hosts and other pathogens.
